M Bojar

Publications (5)7.38 Total impact

• Article: EFNS guideline on the management of community-acquired bacterial meningitis: report of an EFNS Task Force on acute bacterial meningitis in older children and adults.

  A Chaudhuri, P Martinez-Martin, P M Martin, P G E Kennedy, R Andrew Seaton, P Portegies, M Bojar, I Steiner
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  ABSTRACT: Acute bacterial meningitis (ABM) is a potentially life-threatening neurological emergency. An agreed protocol for early, evidence-based and effective management of community-acquired ABM is essential for best possible outcome. A literature search of peer-reviewed articles on ABM was used to collect data on the management of ABM in older children and adults. Based on the strength of published evidence, a consensus guideline was developed for initial management, investigations, antibiotics and supportive therapy of community-acquired ABM. Patients with ABM should be rapidly hospitalized and assessed for consideration of lumbar puncture (LP) if clinically safe. Ideally, patients should have fast-track brain imaging before LP, but initiation of antibiotic therapy should not be delayed beyond 3 h after first contact of patient with health service. In every case, blood sample must be sent for culture before initiating antibiotic therapy. Laboratory examination of cerebrospinal fluid is the most definitive investigation for ABM and whenever possible, the choice of antibiotics, and the duration of therapy, should be guided by the microbiological diagnosis. Parenteral therapy with a third-generation cephalosporin is the initial antibiotics of choice in the absence of penicillin allergy and bacterial resistance; amoxicillin should be used in addition if meningitis because of Listeria monocytogenes is suspected. Vancomycin is the preferred antibiotic for penicillin-resistant pneumococcal meningitis. Dexamethasone should be administered both in adults and in children with or shortly before the first dose of antibiotic in suspected cases of Streptococcus pneumoniae and H. Influenzae meningitis. In patients presenting with rapidly evolving petechial skin rash, antibiotic therapy must be initiated immediately on suspicion of Neisseria meningitidis infection with parenteral benzyl penicillin in the absence of known history of penicillin allergy.
  European Journal of Neurology 08/2008; 15(7):649-59. · 3.69 Impact Factor
• Chapter: Neurological Complications of Hiv Infection

  P. Portegies, L. Solod, P. Cinque, A. Chaudhuri, J. Begovac, I. Everall, T. Weber, M. Bojar, P. Martinez-Martin, P. G. E. Kennedy
  01/2008: pages 386 - 395; , ISBN: 9780470753279
• Source

  Available from: Josip Begovac

  Article: Guidelines for the diagnosis and management of neurological complications of HIV infection.

  P Portegies, L Solod, P Cinque, A Chaudhuri, J Begovac, I Everall, T Weber, M Bojar, P Martinez-Martin, P G E Kennedy
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  ABSTRACT: The spectrum of neurological complications of HIV-infection has remained unchanged through the years, but its epidemiology changed remarkably as a result of the introduction of highly active antiretroviral therapy (HAART). Guidelines for the diagnosis and treatment of cerebral toxoplasmosis, cryptococcal meningitis, progressive multifocal leukoencephalopathy, CMV encephalitis, CMV polyradiculomyelitis, tuberculous meningitis, primary CNS lymphoma, HIV dementia, HIV myelopathy and HIV polyneuropathy are given with a grading of evidence and recommendations.
  European Journal of Neurology 06/2004; 11(5):297-304. · 3.69 Impact Factor
• Article: EFNS guideline on the management of community-acquired bacterial meningitis: report of an EFNS Task Force on acute bacterial meningitis in older children and adults

  A Chaudhuri, PM Martin, PG Kennedy, RA Seaton, P Portegies, M Bojar, I Steiner
• Article: Guidelines for the diagnosis and management of neurological complications of HIV infection

  P Portegies, L Solod, P Cinque, A Chaudhuri, J Begovac, I Everall, T Weber, M Bojar, P Martinez-Martin, PGE Kennedy