Sandrine De Montgolfier

Publications (6)7.21 Total impact

• Article: [Maternity for others: from desiring a child to desiring a child at any price].

  Sandrine de Montgolfier, Aude Mirkovic
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  ABSTRACT: Surrogacy is prohibited by French law. On December 17th 2008 the French Court of Cassation has refused the transcription on the French register of civil status of U.S. birth certificates of children born to a surrogate mother in California. Some have been requesting that legislators amend current laws so as to legalize the practice. Such a claim is far from unanimous. Two successive reports of the French Parliament have underlined their opposition to such modifications: the first report has been delivered by a working group of the Senate and the second by the Parliamentary Office for Scientific and Technological Choices. We propose to analyze the elements that are opposed to the legalization of the practice. We do not underestimate the suffering of couples without children or the love they want to give but if surrogacy is forbidden it is because of the numerous difficulties it entails and that can not be bypassed by sentimental considerations.
  Medecine sciences: M/S 05/2009; 25(4):419-22. · 0.64 Impact Factor
• Article: Communication of pharmacogenetic research results to HIV-infected treated patients: standpoints of professionals and patients.

  Grégoire Moutel, Nathalie Duchange, François Raffi, Lama I Sharara, Ioannis Théodorou, Violaine Noël, Sandrine de Montgolfier, Ingrid Callies, François Bricaire, Christian Hervé, Catherine Leport
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  ABSTRACT: The aim of pharmacogenetic studies is to adapt therapeutic strategies to individual genetic profiles, thus maximising their efficacy and minimising the likelihood of adverse side effects. Since the advent of personalised medicine, the issue of communicating research results to participants has become increasingly important. We addressed this question in the context of HIV infection, as patients and associations are particularly concerned by research and therapeutic advances. We explored the standpoints of both research professionals and participants involved in a pharmacogenetic study conducted in a cohort of HIV-infected patients. The setting of the research protocol was followed over a 2-year period. Participants' standpoints were collected through a questionnaire and interviews were conducted with research professionals. Of 125 participants, 76% wished to receive individual results and 71% wished to receive collective results; 39% did not know when results might be expected. Communication of global research results is a principle that is generally accepted by professionals. Concerning individual feedback, the professionals felt that it was necessary if it could be of direct benefit to the participant, but they expressed doubts for situations with no recognised benefit. Our results highlight the necessity to consider this issue in greater detail. We suggest the need to anticipate the debates concerning individual feedback, to differentiate between situations and the importance of further investigations on the opportunities and modalities of communication. Finally, our work emphasised the opposite pressures between the pursuit of scientific knowledge and the therapeutic orientation of clinical trials.
  European Journal of HumanGenetics 10/2005; 13(9):1055-62. · 4.40 Impact Factor
• Source

  Available from: Grégoire Moutel

  Article: Study of the involvement of research ethics committees in the constitution and use of biobanks in France.

  Grégoire Moutel, Sandrine De Montgolfier, Nathalie Duchange, Lama Sharara, Catherine Beaumont, Christian Hervé
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  ABSTRACT: Concerns are emerging about the protection of individuals who take part in genetic research involving biobanks. We used several items of a questionnaire sent to 48 French research ethics committees (RECs) to investigate the means by which they evaluate the constitution and use of biobanks, and the elements on which conclusions were based. Most RECs felt they should evaluate the constitution of biobanks in protocols, but not all did so in practice. Harmonization of the competence of RECs for evaluating biobanks is required, particularly concerning information, consent, the duration of sample conservation and the communication of research results. Our results, together with those of others, demonstrate the need to develop rules and guidelines based on common ethical approaches, particularly in the European environment.
  Pharmacogenetics 04/2004; 14(3):195-8.
• Article: Ethical reflections on pharmacogenetics and DNA banking in a cohort of HIV-infected patients.

  Sandrine de Montgolfier, Grégoire Moutel, Nathalie Duchange, Ioannis Theodorou, Christian Hervé, Catherine Leport
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  ABSTRACT: The aim of this study was to analyse ethical issues concerning the storage of human biological samples to be used in genetic analyses and pharmacogenetic research based on a French experience of DNA banking in a cohort of human immunodeficiency virus (HIV)-infected patients started on a protease inhibitor-containing treatment. We describe the ethical issues raised during the establishment of a DNA bank, including questions dealing with autonomy, benefit to the patient, information sharing and confidentiality as well as guarantees concerning the storage and use of DNA. The practical applications of themes illustrated theoretically in the literature are discussed. Most of the points raised are not specific to HIV, but some of them may be more accurate due to the characteristics of the HIV population, which is more involved in the social debate through the community life and the increased risk of stigmatization. Our results are summarized in the memorandum and consent form presented in the Appendices. One issue still open to discussion is the way the results of genetic data will be given to the patients. This work should allow other researchers and members of evaluation committees to enrich their considerations and should stimulate discussion on this topic.
  Pharmacogenetics 01/2003; 12(9):667-75.
• Source

  Available from: Grégoire Moutel

  Article: Evaluation of biobank constitution and use: multicentre analysis in France and propositions for formalising the activities of research ethics committees.

  Sandrine de Montgolfier, Grégoire Moutel, Nathalie Duchange, Ingrid Callies, Lama Sharara, Catherine Beaumont, Josué Feingold, Christian Hervé
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  ABSTRACT: Biobanks are collections of biological material and related files gathered and stored for clinical or research purposes. Here, we investigated the questions raised during the evaluation of biobanks by biomedical Research Ethics Committees (RECs), particularly in the context of genetic research. We sent a questionnaire to all RECs in France to survey their concerns and the ethical criteria used when evaluating research involving the storage of biological samples. Most of the RECs think that they should be consulted to evaluate the constitution of biobanks. The proportion of RECs of this opinion depended on whether the biobank is being constituted in the absence of an associated research project (initially created for clinical purposes or for undefined research) (14/28), whether the biobank is being constituted for research use (21/28) or whether an existing research biobank is being re-used (19/28). Views diverged concerning the way ethics principles are applied, showing that REC evaluations of biobanks might be formalised at each of the following steps: constitution, use and re-use. In this paper, we suggest concrete elements that could be integrated into the application of the new French law concerning the protection of the human beings participating in research as well as into international recommendations.
  European Journal of Medical Genetics 49(2):159-67. · 2.18 Impact Factor
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  Available from: Grégoire Moutel

  Article: Evaluation éthique des lois de bioéthique à partir de deux exemples : les banques d'ADN et le devenir des embryons.

  Grégoire Moutel, Sandrine De Montgolfier, Nathalie Duchange, Irène François, Christian Hervé
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  ABSTRACT: Pas de résumé