Wen-hua Wang

Shanghai Jiao Tong University, Shanghai, Shanghai Shi, China

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Publications (29)25.61 Total impact

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    ABSTRACT: The colloidal gold immunochromatographic test strip was developed in order to establish a rapid detection assay of Domoic acid (DA) content in marine shellfish. The colloidal gold with particle diameter 20 nm was obtained by reducing gold chloride with sodium citrate. After identification by electron micrograph, optimum conditions for labeling were determined and colloidal gold was labeled by DA monoclonal antibody. The gold-labeled antibody was coated on some chosen glass fiber and dried. The coating antigen (DA-BSA) and Goat anti Mouse IgG were spotted respectively on a piece of nitrate fiber membrane as test line and control line. Finally the test strips were constructed and the detection sensitivity was measured. The results showed that, the detection limit of colloidal gold immunochromatographic test strip was 20 ng/mL and the whole analysis process could be completed within 15 min. The method established is sensitive and the procedure of determination is simple and quick without special equipment. The colloidal gold immunochromatographic test strip could be widely used for batch detection of domoic acid in shellfish on site and has great prospect for commercial development.
    Huan jing ke xue= Huanjing kexue / [bian ji, Zhongguo ke xue yuan huan jing ke xue wei yuan hui "Huan jing ke xue" bian ji wei yuan hui.] 08/2011; 32(8):2492-6.
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    ABSTRACT: A rapid biochemical method was discussed in order to detect low concentration of paralytic shellfish poisoning (PSP) in sea food. The mice were injected with PSP extract of bivalves (1 and 0.2 microg/kg respectively, as STX equivalents) purchased from seafood market. ACh, AChE, NO and NOS in blood were studied at 15, 60, 120 min respectively. The results showed that at low dose (0.2 microg/kg) and 15 min, only the contents of ACh changed significantly compared with control group (p < 0.05), which was (141.2 +/- 14.8) microg/mg, while the contents of NO and the activities of NOS changed until 120 min, compared to control group (p < 0.05) ,which were (68.7 +/- 3.8) micromol/g and (40.1 +/- 4.9) U/mg respectively. At high dose the contents of ACh changed at all three time point. It can be suggested that the contents of ACh is the only one of four indexes which can response to PSP at low dose in an early stage (15 min) and may be selected as a biochemical index for rapid detection of PSP.
    Huan jing ke xue= Huanjing kexue / [bian ji, Zhongguo ke xue yuan huan jing ke xue wei yuan hui "Huan jing ke xue" bian ji wei yuan hui.] 07/2010; 31(7):1663-6.
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    ABSTRACT: Accurate physical-chemical properties are of fundamental importance for interpreting and simulating the environmental fate and transport behavior of polycyclic aromatic hydrocarbons (PAHs). A complete set of thermodynamically consistent property data (vapor pressure, aqueous solubility, octanol solubility, octanol−water partition coefficient, octanol−air partition coefficient, and air−water partition coefficient) for 15 PAHs [naphthalene (Nap), acenaphthylene (Acy), acenaphthene (Ace), fluorene (Fluo), phenanthrene (Phe), anthracene (Ant), fluoranthene (Flu), pyrene (Pyr), chrysene (Chry), benzo[a]anthracene (BaA), benzo[b]fluoranthene (BbF), benzo[k]fluoranthene (BkF), benzo[a]pyrene (BaP), dibenzo[a,h]anthracene (DBA), indeno[1,2,3-c,d]pyrene (IP), and benzo[g,h,i]perylene (BghiP)] is derived from measured data reported in the literature. First, literature-derived values (LDVs) at 25 °C for each property and compound are obtained by averaging, regression, and extrapolation. Then the LDVs for each compound are adjusted to conform to the thermodynamic relationships between them using a least-squares adjustment procedure. The influence of the mutual solubility of octanol and water on phase partitioning is taken into account in the adjustment of KOW. Compared to other semivolatile organic compounds, the LDVs for the PAHs display a high degree of thermodynamic consistency and require only minor adjustments. The LDVs and the adjusted values for all properties show highly linear regressions with molar mass.
    Journal of Chemical & Engineering Data 11/2009; 55(2). · 2.05 Impact Factor
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    ABSTRACT: Distribution and risk assessment of polycyclic aromatic hydrocarbons (PAHs) in drinking water resources have been carried out for the first time in Henan Province, China. Water samples collected from four river systems and their tributaries, as well as groundwater resources, were analyzed according to EPA method 525.2. Total of 68 water samples were collected in 18 cities in Henan province in May, August and November, 2001. Concentrations of sum of 16 priority PAHs in water samples ranged from 15 to 844 ng/L with a mean value of 178 +/- 210 ng/L (n = 68). The spatial and temporal distribution of PAHs showed that the Huanghe and the Huaihe river systems had relatively higher concentrations of total PAHs. Higher concentrations of total PAHs were observed in August and November than in May, with respective mean values of 262, 232 and 33.6 ng/L. Ratios of Ant/(Ant + Phe) and Flur/(Flur + Pyr) were calculated to evaluate the possible sources of PAH contamination, which indicated that the coal combustion sources were the main contributors to PAHs in most drinking water resources. Some petrogenic (or pyrolytic) sources of PAHs were also found. The toxic equivalency factors (TEFs) were used to calculate benzo[a]pyrene equivalents (BaPE) for water samples. The average value of BaPE was 0.6 ng/L. The values in most stations were much lower than the guideline values in drinking water of Chinese Environmental Protection Agency (CEPA, 2.8 ng/L) and the US Environmental Protection Agency (US EPA, 200 ng/L). Overall, the drinking water resources in Henan province showed some carcinogenic potential.
    Environmental Monitoring and Assessment 01/2008; 146(1-3):127-38. · 1.68 Impact Factor
  • Australian Journal of Soil Research 01/2008; 46(5). · 3.44 Impact Factor
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    ABSTRACT: In order to gain comprehensive understanding of status, properties and sources of PCBs pollution at an industrial area in Shanghai, PM10 were collected during the period November 2004-September 2005. The results showed that the mean value of total PCBs in the industrial area was 2,017.22 pg m(-3). Three dioxin-like PCB congeners had a mean value of TEQ of 0.24 pg-TEQ m(-3). The concentrations of PCBs at all sites were higher in colder months than in warmer months. SigmaPCB concentrations were correlated positively with SO2, NO2 and OCPs, while negatively with polycyclic aromatic hydrocarbons (PAHs), ambient temperature, rainfall and wind speed. It could be concluded that the area had been contaminated by PCBs from a local source.
    Bulletin of Environmental Contamination and Toxicology 11/2007; 79(4):448-53. · 1.22 Impact Factor
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    ABSTRACT: In order to study the distributions characteristics, sources and relationship of PAHs in PM10- phoenix tree leaves-soil system of a coking & chemical factory in Shanghai, the samples of PM10, phoenix tree leaves and soil around the factory were collected for a year. The concentration of PAHs were analyzed according to the USEPA method 8 000 series. The results showed that the average concentration of PAHs in PM10, phoenix tree leaves and soil were 101.11 ng/m3, 79.45 ng/g and 121.53 microg/g, respectively. Particulate phase (PM10) contained mainly carcinogenic and mutagenic PAHs, among which BaA, BghiP, Flu and BaP were found at significant concentrations. In phoenix tree leaves, Nap,Chy, BaP and BghiP presented a higher level of concentration. In soil, 3 and 4-ring PAHs presented a higher level. PAHs concentrations of phoenix tree leaves were very lower in May. Only Ace (0.16 ng/g) and Pyr (0.63 ng/g) were detected. In July and August the concentrations (39.19 ng/g and 150.94 ng/g, respectively) were uplifted significantly. It could be concluded PAHs was from petroleum and coal-fired compound source. There were very strong positive relationships of 16 PAHs level among phoenix tree leaves, soil and PM10 (p < 0.01).
    Huan jing ke xue= Huanjing kexue / [bian ji, Zhongguo ke xue yuan huan jing ke xue wei yuan hui "Huan jing ke xue" bian ji wei yuan hui.] 08/2007; 28(8):1802-5.
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    ABSTRACT: To study the oxidative stress induced by consumption of mercury-contaminated rice in rats, and to assess the possible public health risk of mercury contamination in Wanshan mining area. Sprague Dawley rats were fed the mercury-contaminated rice produced from Wanshan area for 90 days. The antioxidant status and the free radicals in rat serum were evaluated. High mercury accumulation in organs of rats fed the mercury-contaminated rice confirmed the server pollution of mercury in Wanshan mining area. The intensity of electron spin resonance (ESR) signal increased by 87.38% in rats fed the rice from Wanshan compared with that in the control rats fed the rice from Shanghai, suggesting that chronic dietary consumption of rice from mercury mining area could induce an aggravation of free radicals. Feeding the mercury-contaminated rice was associated with significant decreases in the antioxidant enzymatic activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and concentration of serum nitric oxide (NO), but it had no effect on serum nitric oxide synthase (NOS) activity. Feeding the mercury-contaminated rice raised the level of serum malonyldialdehyde (MDA), indicating the occurrence of oxidative stress. The long-term dietary consumption of mercury-contaminated rice induces the aggravation of free radicals and exerts oxidative stress.
    Biomedical and Environmental Sciences 03/2007; 20(1):84-9. · 1.26 Impact Factor
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    ABSTRACT: Huangpu River is about 114.5 km from upriver Dianfeng to downriver Wusong, near the estuary of the Yangtze River. It plays a key role in supplying water for production, life, shipment and irrigation. With the industrial development, the pollution of the Huangpu River has become serious recently. The biological oxygen demand (BOD), total nitrogen (TN), total phosphorus (TP), oil, phenol and suspended solids (SS) were lower in the upstream sites than in the downstream sites, indicating pollutants being input along its course. Water quality was the worst in the Yangpu site, near the center of Shanghai City. Dissolved oxygen (DO) content was less than 2 mg/L in the site of Yangpu in July. Among relations between thirteen characteristics, relations between BOD, DO, TN, TP, NH4(+)-N, NO3(-)-N and the count of total bacteria or Escherichia coli were significant and interdependent. Inner relationships between these main characteristics in the Huangpu River were studied. High nutrient concentration led to growth of microorganisms, including E. coli. Degradation of organic matters and respiration of bacteria made oxygen concentration decreased in the water body, and DO was a key factor for nitrification-denitrification process of nitrogen. In the Yangpu site, DO was decreased to less than 3.0 mg/L with BOD higher than 7.5 mg/L in May and July. Low DO concentration will decrease nitrification rate. Nitrification need at higher DO value than other organic substrate oxidation. Consequently, river water contains low NO3(-)-N values with high amounts of TN and NH4+-N there. This will block the self-purification of surface water, by decreasing the rate of nitrification-denitrification transformation process in the water body.
    Journal of Environmental Sciences 02/2007; 19(10):1193-8. · 1.92 Impact Factor
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    ABSTRACT: Laogang landfill near Shanghai is the largest landfill in China, and receives about 10000 t of daily garbage per day. Samples of topsoil and plants were analyzed to evaluate mercury pollution from the landfill. For topsoil samples, there were significant correlations among total mercury (HgT), combinative mercury (HgC) and gaseous mercury (HgG), and content of total organic carbon (TOC), but, no significantly relationship was found between Hg content and filling time. Hg content changes in vertical profiles with time showed that the average HgT of profiles 1992, 1996, and 2000 was similar, but their average HgG was quite different. HgT was significantly correlated with HgC in profile 1992 and 2000, and HgT was significantly correlated with HgG in profile 1996. HgG/HgT ratio in profile samples decreased in the order of (HgG/HgT)1992 > (HgG/Hg)1996 > (Hg/HgT)2000. A simple outline of Hg release in landfill could be drawn: with increasing of filling time, degradation undergoes different biodegradation, accordingly, gaseous mercury goes through small, more, and small proportion to total mercury. Distribution of Hg in plants was inhomogeneous, following the order of leaf > root > stem. The highest value of leaf may be associated with higher atmospheric Hg from landfill. Ligneous plants (e.g. Phyllostachys glanca, Prunus salicina and Ligustrum lucidum) are capable of enriching more Hg than herbaceous plants.
    Journal of Environmental Sciences 02/2007; 19(2):200-4. · 1.92 Impact Factor
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    ABSTRACT: Sprague-Dawley rats were reared by environmental mercury contaminated rice to survey the potential health risk of Wanshan mercury mining area. Electron spin resonance (ESR) was introduced to detect the species and the intensities of free radicals, using spin trap 5,5-dimethyl-1-pyrroline-N-oxide (DMPO). The results showed that the mercury-contaminated rice significantly increased the levels of free radicals and MDA in rat brain at 7 days (p < 0.05). ESR spectrums showed that the principal spin adducts resulted from the trapping of alkyl free radical (alphaH = 22.7 x 10(-4)T +/- 1.6 x 10(-4)T, alphaN = 15.5 x 10(-4)T +/- 0.5 x 10(-4)T), and hydroxyl radical. Levels of free radicals and MDA increased slowly until after 90-day exposure period (83%, 100%). Element correlation analysis showed high correlations of mercury and selenium in the brain of rat fed with Wanshan rice, suggesting that the coexisting selenium in rice exhibited antagonistic effects on both mercury accumulation and toxicity. The slight increases of free radicals in rat brain at 7, 20 and 30-day exposure periods should be related with the scavenger effect of Se.
    Huan jing ke xue= Huanjing kexue / [bian ji, Zhongguo ke xue yuan huan jing ke xue wei yuan hui "Huan jing ke xue" bian ji wei yuan hui.] 10/2006; 27(10):2087-90.
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    ABSTRACT: In order to probe to the factors for mercury accumulation to natural surface coating, we study the concentration of mercury in Huangpu River surface coatings developed for different depth, different grown days and different seasons and analysis mercury forms of occurrence. The result show the organic matter in biofilm is much high (7.5%-14.5%). Growth time, depth and seasons are all important factors for mercury accumulation to surface coating. Illumination and temperature was stronger and the growth day was longer, The concentration of mercury in biofilm was higher. The mercury forms of occurrence in surface coating were mainly residual matter bound mercury (41.98%) and organic acids bound mercury (27.89%). The percentage of carbonate bound mercury (10.17%) and ion exchangeable mercury (5.33%) was little.
    Huan jing ke xue= Huanjing kexue / [bian ji, Zhongguo ke xue yuan huan jing ke xue wei yuan hui "Huan jing ke xue" bian ji wei yuan hui.] 08/2006; 27(7):1406-9.
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    ABSTRACT: This study is to determine differentially expressed genes in the brain of rat exposed to mercury chloride and investigate the molecular mechanism of mercury neurotoxicity using cDNA microarray. The experimental group of rats were treated with 0.5 mg/kg weight of mercury chloride via hypodermic injection. The differentially expressed genes in rat brains after I h of injection were scanned by the cDNA microarray. The gene expression profiles show that there are 742 genes, in which 562 are upregulated and 180 are downregulated. Further analysis by bioinformatic technique disclosed that the differentially expressed genes were involved in many biological processes, which included immuno-response and detoxifcation, transfer and expression of genetic information, cell signalling, neurotransduction, cell proliferation and cell differentiation, apoptosis, etc. The result of analysis indicated these genes might be related to the neurotoxicity of mercury. The investigation of differentially expressed genes using cDNA microarray provides a new approach to further disclose the neurotoxic mechanism of mercury.
    Huan jing ke xue= Huanjing kexue / [bian ji, Zhongguo ke xue yuan huan jing ke xue wei yuan hui "Huan jing ke xue" bian ji wei yuan hui.] 05/2006; 27(4):779-82.
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    ABSTRACT: Wanshan mercury mine is the largest mercury deposit in Guizhou Province of China, but there were few reports on mercury toxic effect in the mining area. In order to study the neurotoxicity of food from Wanshan mercury mine area and probe into the effect of food from Wanshan mercury miner area on the changes of brain oxidative damage and expression of c-fos gene. The rats were exposed to mercury contaminated food for 20 d. The content of malondialdehyde (MDA), superoxide dismutase (SOD), GSH-peroxidase (GSH-px) and Glutathione (GSH) in rat brain was measured, and the effect of mercury contaminated rice on the expression of c-fos mRNA in rat brain and the expression of c-FOS protein in cortex, hippocampus were observed using reverse transcription polymerase chain reaction (RT-PCR) and immunocytochemical methods. The results showed the levels of GSH, MDA, SOD and of GSH-dependent enzymes in the rat brain changed between exposure groups and control group; The mercury polluted rice induced significantly the expression of c-fos mRNA; the c-FOS positive cells in hippocampus and cortex of exposure groups were significant different from control group (P<0.01). It could be concluded that oxidative stress signals could contribute to the induction of immediate early genes (IEGs); free radicals and their by-products might not only cause oxidative damage, but also influenced gene expression; IEGs c-fos participated in the toxicity process of brain injury by mercury polluted food.
    Journal of Environmental Sciences 02/2006; 18(4):788-92. · 1.92 Impact Factor
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    ABSTRACT: In order to survey the potential health risk of environmental exposure by mercury, Sprague-Dawley rats were reared by mercury contaminated rice from mercury mining area. The changes of neurotransmitter acetylcholine (ACh) and acetylcholinesterase (AChE) in rat brain were examined at different times. The results show that the mercury-contaminated rice significantly increase the content of ACh in rat brain after exposure for 7 days. ACh maintained at a high level even after exposure for 30 days, but decreased significantly after exposure for 90 days. The changes of AChE represented an inverse trend compared with that of ACh. The coexisting selenium in rice exhibited antagonistic effects on both mercury accumulation and toxicity. The findings suggested that neurotoxic effects of environmental mercury contamination had been significantly represented after chronically dietary exposure. Further studies are needed to examine the relationship between the neurotransmitter level changes and the Alzheimer's Disease (AD).
    Huan jing ke xue= Huanjing kexue / [bian ji, Zhongguo ke xue yuan huan jing ke xue wei yuan hui "Huan jing ke xue" bian ji wei yuan hui.] 02/2006; 27(1):142-5.
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    ABSTRACT: To probe into the prelude marker of central nervous system injury in response to methyl mercury chloride (MMC) stimulation and the signal transduction molecular mechanism of injury in rat brain induced by MMC. The expression of c-fos mRNA in brain and the expression of c-FOS protein in cortex, hippocampus and ependyma were observed using reverse transcription polymerase chain reaction (RT-PCR) and immunocytochemical methods. The control group was injected with physiological saline of 0.9%, while the concentrations for the exposure groups were 0.05 and 0.5, 5 mg/kg MMC respectively, and the sampling times points were 20, 60, 240, 1440 min. The expression of c-FOS protein in cortex and hippocampus increased significantly, the accumulation of mercury in the brain induced by 0.05 mg/Kg MMC for 20 min had no significant difference compared with the control group. The mean value was 0.0044 mg/Kg, while the protein c-FOS expression had significant difference compared with the control group (P < 0.01). More sensitive expression occurred in hippocampus and cortex, but not in ependyma. Conclusion The expression of c-FOS protein in cortex and hippocampus can predict the neurotoxicity of MMC in the early time, and immediately early gene (IEG) c-fos participates in the process of brain injury induced by MMC.
    Biomedical and Environmental Sciences 02/2006; 19(1):67-72. · 1.26 Impact Factor
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    ABSTRACT: Levels of total mercury, soluble mercury and particle mercury in water of Huangpu River change greatly, their average values are (0.4 +/- 0.44) ng/mL, (0.27 +/- 0.42)ng/mL, (0.13 +/- 0.10) ng/mL respectively. Mercury in water is mainly in the form of soluble mercury. Average mercury content in sediment of Huangpu River is relative high and up to (204.03 +/- 97.41) ng/g, with a range of 70.52 ng/g - 387.30 ng/g. Mercury content is high in the middle reach of Huangpu River, especially in section of Xidu-Nanpu Bridge, and low in upstream and downstream. Distribution of mercury is hightly related with distribution of industry plants and farming. Locations with high mercury content in sediment are in the downstream of locations with high mercury content in water. Mercury (in sediments) is mainly in the form of residue, exchangeable ions, and humics-bound, seldom is in the form of carbonate-bound. Contrary to residue-bound mercury, exchangeable mercury is low in the middle reach, and high in upstream and downstream. There mainly are residue-bound mercury and little humics-bound mercury, exchangeable mercury, and carbonate-bound mercury in sediment in profile, and the residue-bound mercury increases irregularly with depth. Nearing the Mouth of Yangtze River, mercury in sediment becomes more active.
    Huan jing ke xue= Huanjing kexue / [bian ji, Zhongguo ke xue yuan huan jing ke xue wei yuan hui "Huan jing ke xue" bian ji wei yuan hui.] 10/2005; 26(5):62-6.
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    ABSTRACT: Acid red B (ARB) solution with pH = 3 was electrolyzed in a two-chamber cell using Pt/C gas diffusion electrode (GDE) as cathode. The color and COD removal ratio in cathode chamber were 94.2% and 66.8% respectively; and the color and COD removal ratio in anode chamber were 73.3% and 56.6% respectively, which indicated that O2 can be reduced to H2O2 and x OH in the cathode chamber, then ARB was degraded. Through IR and GC-MS analysis for the intermediates of ARB in the cathode chamber, 20 intermediates have been detected, including 14 esters, 3 acids and 3 compounds with -NO2 or N-OH groups and the probable degradation pathway of ARB in the cathode chamber was given.
    Huan jing ke xue= Huanjing kexue / [bian ji, Zhongguo ke xue yuan huan jing ke xue wei yuan hui "Huan jing ke xue" bian ji wei yuan hui.] 10/2005; 26(5):115-9.
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    ABSTRACT: This paper reports 20 organochlorine pesticides (OCPs) in surface sediments of Huangpu River in Shanghai, China. Pesticides were analyzed by GC/ECD with dual column. The concentration range of sigmaOCPs in sediments was 2.65-19.54 ng/g. DDTs, BHCs, methoxychlor and dieldrin had higher concentration than others. The concentration range of DDTs and BHCs was 0.68-4.43 ng/g and 0.14-0.77 ng/g, respectively, which shows concentration of DDTs was higher than BHCs. OCPs content increasing from upper to downstream Huangpu River implicats that discharging of industrial effluents and inflow of Suzhou River offered lots of OCPs to middle-lower Huangpu River. Distribution of OCPs components indicate that OCPs in sediments may be derived from the aged and weathered agricultural soils. According to correlation analysis between OCPs and TOC of sediments, TOC content influences the distribution of OCPs in sediment strongly. Contamination level of OCPs in sediment of Huangpu River is relatively lower than other areas. Comparing with ERL and ERM value of risk evaluation, sediments in middle-lower Huangpu River pose a bit high risk to consumers of bottom feeders.
    Huan jing ke xue= Huanjing kexue / [bian ji, Zhongguo ke xue yuan huan jing ke xue wei yuan hui "Huan jing ke xue" bian ji wei yuan hui.] 06/2005; 26(3):44-8.
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    ABSTRACT: Mercury (Hg), as one of the priority pollutants and also a hot topic of frontier environmental research in many countries, has been paid higher attention in the world since the middle of the last century. Guizhou Province (at N24 degrees 30'-29 degrees 13', E103 degrees 1'-109 degrees 30', 1 100 m above the sea level, with subtropical humid climate) in southwest China is an important mercury production center. It has been found that the mercury content in most media of aquatics, soil, atmosphere and in biomass of corns, plants and animals, is higher than the national standard. The present study aims to explore the influence of mercury pollution on the health of local citizens. The effect of rice from two mercury polluted experimental plots of Guizhou Province on the expression of c-jun mRNA in rat brain and c-jun protein in cortex, hippocampus and ependyma was observed using reverse transcription polymerase chain reaction (RT-PCR) and immunocytochemical methods. The results showed that the mercury polluted rice induced expression of c-jun mRNA and its protein significantly. Selenium can reduce Hg uptake, an antagonism between selenium and mercury on the expression of c-jun mRNA and c-jun protein. c-jun participates in the toxicity process of brain injury by mercury polluted rice, the expression of c-jun mRNA in brain, and c-jun protein in rat cortex and hippocampus can predict neurotoxicity of mercury polluted rice. People should be advised to be cautious in eating any kind of Hg-polluted foods. To reveal the relationship between c-jun induction and apoptosis, further examinations are required.
    Biomedical and Environmental Sciences 05/2005; 18(2):96-102. · 1.26 Impact Factor