Thomas Kubiak

Johannes Gutenberg-Universität Mainz, Mayence, Rheinland-Pfalz, Germany

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Publications (68)175.6 Total impact

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    ABSTRACT: Recent research has shown that mindfulness moderates the negative emotional reactivity associated with neuroticism. In two studies, we investigated how neuroticism and mindfulness are associated with subjective well-being (SWB), assuming a moderated mediation. In Study 1, 147 participants (74.2% female, M = 34.3 years, SD = 11.9) completed an online survey. Mindfulness partially mediated but did not moderate the relationship between neuroticism and SWB, indicating that low levels of mindfulness were partially accountable for lower SWB in individuals high in neuroticism. In Study 2, 108 participants (80.6% female, M = 25.2 years, SD = 6.6) completed daily diaries for 6 days. We found evidence for a moderated mediation in trait as well as daily measures of mindfulness and SWB, in that the lack of mindfulness could explain around one quarter of the negative association between neuroticism and SWB. This mediation was moderated by neuroticism itself in Study 2, in that mindfulness was only a significant mediator for high levels of neuroticism. Our findings demonstrate that negative emotional reactivity associated with neuroticism is partially due to low levels of mindfulness, which offers a promising future research avenue for the role of mindfulness.
    Personality and Individual Differences 07/2015; 80. DOI:10.1016/j.paid.2015.02.020 · 1.86 Impact Factor
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    ABSTRACT: Ambulatory Assessment (AA) comprises the use of in-field methods to assess individuals’ behavior, physiology, and the experience as they unfold in naturalistic settings. We propose that AA is favorable for the investigation of gene–environment interactions and for the search for endophenotypes, being able to assess the experienced environment and to track basic regulatory processes, such as stress reactivity, affective instability, and reward experience, which are potential common factors that underlie psychiatric disorders.In this article, we (a) first describe briefly the rationale of AA and summarize the key advantages of the approach, (b) highlight within-subject regulatory processes, such as stress reactivity, affective instability, and reward experience, (c) describe studies that used AA to examine genetic influences in psychiatric disorders, and (d) briefly review longitudinal studies that have investigated phenotypes of psychiatric disorders.The reported studies yielded promising, although sometimes inconclusive evidence for genetic effects on endophenotypes of psychiatric disorders. Moreover, most studies were twin or family studies, especially in stress-sensitivity research; thus, it is unclear which specific single nucleotide polymorphisms contribute to the endophenotypes of psychiatric disorders. We do hope that within-subject regulatory processes will enable us to clarify the fundamental psychological dimensions that cut across traditional disorders and link them to their genetic underpinnings.
    Neuroscience Research 11/2014; DOI:10.1016/j.neures.2014.10.018 · 2.15 Impact Factor
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    ABSTRACT: High levels of cell free DNA (cfDNA) in human blood plasma have been described in patients with autoimmune diseases. The aim of this study was to determine the levels of cfDNA in systemic lupus erythematosus (SLE) patients and to assess fluctuations of cfDNA concentrations compared to the course of disease progression under standard treatment. Therefore, nuclear cfDNA concentrations in plasma were measured in 59 SLE patients and 59 healthy controls. Follow-up blood plasma was collected from 27 of the 59 SLE patients. Patients were characterised by clinical parameters (antinuclear antibodies (ANA), anti-dsDNA-antibodies, C3, C4, and CRP), SLE disease activity index (SLEDAI) and medical therapy. Our results showed that cfDNA concentrations were significantly higher in SLE patients compared to healthy individuals. Levels of cfDNA assessed in serial samples correlated significantly with the medical evaluation of disease activity in SLE patients. Our results could implicate cfDNA as a global marker for disease activity.
    Cellular Immunology 08/2014; DOI:10.1016/j.cellimm.2014.08.002 · 1.87 Impact Factor
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    Dataset: Methods S1
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    ABSTRACT: Cell-free DNA (cfDNA) in body tissues or fluids is extensively investigated in clinical medicine and other research fields. In this article we provide a direct quantitative real-time PCR (qPCR) as a sensitive tool for the measurement of cfDNA from plasma without previous DNA extraction, which is known to be accompanied by a reduction of DNA yield. The primer sets were designed to amplify a 90 and 222 bp multi-locus L1PA2 sequence. In the first module, cfDNA concentrations in unpurified plasma were compared to cfDNA concentrations in the eluate and the flow-through of the QIAamp DNA Blood Mini Kit and in the eluate of a phenol-chloroform isoamyl (PCI) based DNA extraction, to elucidate the DNA losses during extraction. The analyses revealed 2.79-fold higher cfDNA concentrations in unpurified plasma compared to the eluate of the QIAamp DNA Blood Mini Kit, while 36.7% of the total cfDNA were found in the flow-through. The PCI procedure only performed well on samples with high cfDNA concentrations, showing 87.4% of the concentrations measured in plasma. The DNA integrity strongly depended on the sample treatment. Further qualitative analyses indicated differing fractions of cfDNA fragment lengths in the eluate of both extraction methods. In the second module, cfDNA concentrations in the plasma of 74 coronary heart disease patients were compared to cfDNA concentrations of 74 healthy controls, using the direct L1PA2 qPCR for cfDNA quantification. The patient collective showed significantly higher cfDNA levels (mean (SD) 20.1 (23.8) ng/ml; range 5.1-183.0 ng/ml) compared to the healthy controls (9.7 (4.2) ng/ml; range 1.6-23.7 ng/ml). With our direct qPCR, we recommend a simple, economic and sensitive procedure for the quantification of cfDNA concentrations from plasma that might find broad applicability, if cfDNA became an established marker in the assessment of pathophysiological conditions.
    PLoS ONE 03/2014; 9(3):e87838. DOI:10.1371/journal.pone.0087838 · 3.53 Impact Factor
  • Journal of Social and Clinical Psychology 12/2013; 32(10):1075-1094. DOI:10.1521/jscp.2013.32.10.1075 · 1.36 Impact Factor
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    ABSTRACT: To determine the extent to which geriatric patients with diabetes mellitus experience psychological insulin resistance (PIR). A total of 67 unselected geriatric patients with diabetes (mean age 82.8±6.7 years, diabetes duration 12.2 [0.04-47.2] years, 70.1% female) were recruited in a geriatric care center of a university hospital. A comprehensive geriatric assessment (CGA) was performed including WHO-5, Hospital Anxiety and Depression Scale (HADS), Mini Mental State Examination (MMSE) and Barthel-Index. We assessed PIR using the Barriers of Insulin Treatment Questionnaire (BIT) and the Insulin Treatment Appraisal Scale in a face-to-face interview. Insulin-naïve patients (INP) showed higher PIR scores than patients already on insulin therapy (BIT-sum score: 4.3±1.4 vs. 3.2±1.0; p<0.001). INP reported in the BIT increased fear of injection and self-testing (2.4±2.4 vs. 1.3±0.8; p=0.016), expect disadvantages from insulin treatment (2.7±1.6 vs. 1.9±1.4; p=0.04), and fear of stigmatization by insulin injection (5.2±2.3 vs. 3.6±2.6; p=0.008). Fear of hypoglycemia, however, did not differ significantly (6.3±2.8 vs. 5.1±3.1; p=0.11). Depression was not shown to be a barrier to insulin therapy. INP with diabetes have a significantly more negative attitude toward insulin therapy in comparison to patients already on insulin. Systematic assessment of barriers of insulin therapy, individualized diabetes treatment plans and information of patients may help to overcome such negative attitudes, leading to quicker initiation of therapy, improved adherence to treatment and a better quality of life.
    Patient Education and Counseling 12/2013; 94(3). DOI:10.1016/j.pec.2013.11.010 · 2.60 Impact Factor
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    Mario Wenzel, Thomas Kubiak, Tamlin S Conner
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    ABSTRACT: Positive affect (PA) can either improve or impair self-control performance, depending on whether two tasks are dissimilar, and thus require flexible releasing and switching, or similar, which requires stable maintenance. The present study suggests that this effect is mediated by attentional shifts. The authors found that participants under PA, who performed on two dissimilar tasks and had to switch to a new response dimension, were less attentive to distracting information compared to neutral affect (NE), leading to better performance. In contrast, participants under PA who did not have to switch, were more attentive to distracting information compared to participants under NE. These findings highlight the opposite effects of PA on consecutive self-control.
    Cognition and Emotion 11/2013; DOI:10.1080/02699931.2013.851069 · 2.52 Impact Factor
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    Conference of the Society for Ambulatory Assessment, Amsterdam; 06/2013
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    ABSTRACT: Background: Self-regulatory executive function theory (Wells and Matthews, 1994; Wells, 2008) stresses the role of metacognitions in the development of emotional disorders. Within this metacognitive model, positive beliefs about ruminative thinking are thought to be a risk factor for engaging in rumination and subsequently for depression. However, most of the existing research relies on retrospective self-report trait measures. Aims: The aim of the present study was to examine the theory's predictions with an Ecological Momentary Assessment approach capturing rumination as it occurs in daily life. Method: Non-clinical participants (N = 93) were equipped with electronic diaries and completed four signal-contingent momentary self-reports per day for 4 weeks. A multilevel mediation model was computed to examine associations between positive beliefs about rumination and ruminative thinking and negative affect in daily life. Results: Positive beliefs about rumination were significantly associated with ruminative thinking as it occurs in daily life. We further found evidence for a negative association with positive affect that was completely mediated via ruminative thinking in daily life occurring in response to negative emotions. Conclusions: Our results add ecologically valid corroborating evidence for the metacognitive model of emotional disorders within the framework of self-regulatory executive function theory.
    Behavioural and Cognitive Psychotherapy 05/2013; 42(5):1-9. DOI:10.1017/S1352465813000325 · 1.69 Impact Factor
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    Mario Wenzel, Tamlin S. Conner, Thomas Kubiak
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    ABSTRACT: Performing consecutive self-control tasks typically leads to deterioration in self-control performance. This effect can be explained within the strength model of self-control or within a cognitive control perspective. Both theoretical frameworks differ in their predictions with regard to the impact of affect and task characteristics on self-control deterioration within a two-task paradigm. Whereas the strength model predicts decrements in self-control performance whenever both tasks require a limited resource, under a cognitive control perspective, decrements should only occur when people switch to a different response conflict in the second task. Moreover, only the cognitive control model predicts an interaction between task switching and positive affect. In the present research, we investigated this interaction within a two-task paradigm and found evidence that favored a cognitive control interpretation of the results. Positive affect only benefitted consecutive self-control performance if response conflicts in the two tasks were different (resisting sweets followed by a Stroop task). If they were the same (two consecutive Stroop tasks), positive affect impaired self-control performance. These effects were partially replicated in the second study that also examined negative affect, which did not affect self-control performance. We conclude that drawing on cognitive control models could add substantially to research on self-control.
    European Journal of Social Psychology 04/2013; 43(3):175-184. DOI:10.1002/ejsp.1936 · 1.78 Impact Factor
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    ABSTRACT: The Polyvagal Theory (Porges, 2007) represents a biobehavioral model that relates autonomic functioning to self-regulation and social engagement. The aim of the two presented studies was to test the proposed association of cardiac vagal tone (CVT), assessed via resting high-frequency heart rate variability (respiratory sinus arrhythmia, RSA), with coping, emotion-regulation, and social engagement in young adults. In Study 1 (retrospective self-report), RSA was positively associated with engagement coping (situation control, response control, positive self-instructions, social-support seeking) and aspects of social well-being. In Study 2 (ecological momentary assessment), for 28 days following the initial assessment, RSA predicted less use of disengagement strategies (acceptance and avoidance) for regulating negative emotions and more use of socially adaptive emotion-regulation strategies (i.e., social-support seeking as a reaction to sadness and making a concession as a reaction to anger caused by others). Furthermore, RSA was higher in participants who reported no anger episodes compared to those who reported at least one anger episode and was positively associated with reported episodes of negative emotions. Results support the association proposed by the PVT between CVT and self-regulatory behavior, which promotes social bonds.
    Biological psychology 03/2013; DOI:10.1016/j.biopsycho.2013.02.013 · 3.47 Impact Factor
  • Thomas Kubiak, Arthur A Stone
    Psychosomatic Medicine 05/2012; 74(4):325-6. DOI:10.1097/PSY.0b013e31825878da · 4.09 Impact Factor
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    ABSTRACT: Diabetes mellitus is a known risk factor for cognitive dysfunction and dementia. Chronic hyperglycemia, genetic predisposition, arterial hypertension, hyperlipoproteinemia, micro- and macrovascular diseases, and depression play a major role in the development of cognitive dysfunction. Both pathophysiology of diabetes and dementia and the specifics of diabetes therapy in patients with dementia are presented in this review.
    Zeitschrift für Gerontologie + Geriatrie 01/2012; 45(1):17-22. · 1.02 Impact Factor
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    ABSTRACT: Diabetes mellitus ist ein bekannter Risikofaktor für kognitive Störungen und Demenzerkrankungen. Bei der Entwicklung kognitiver Störungen spielen neben der chronischen Hyperglykämie weitere Faktoren wie genetische Prädisposition, arterielle Hypertonie, Hyperlipoproteinämie, mikro- und makrovaskuläre Erkrankungen sowie die Depression eine wichtige Rolle. In der vorliegenden Übersichtsarbeit werden sowohl die pathophysiologische Zusammenhänge zwischen den Erkrankungen Diabetes und Demenz als auch die Besonderheiten der Diabetestherapie bei Demenzerkrankten differenziert dargestellt.
    Zeitschrift für Gerontologie + Geriatrie 01/2012; 45(1). DOI:10.1007/s00391-011-0269-z · 1.02 Impact Factor
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    ABSTRACT: In this study, we examined whether people’s social well-being is influenced by hostile versus nonhostile goals that people report pursuing when experiencing anger-associated rumination. Moreover, we investigated the impact of trait anger and trait anger rumination on the relationship between anger rumination and perceived social well-being. Participants were 93 students who were equipped with hand-held computers for 28 days to assess anger-related rumination and its social consequences in daily life. Results showed that hostile goal pursuit per se did not affect perceived social well-being. However, impairment of social well-being following hostile rumination was moderated by trait anger. Findings are consistent with recent cognitive models of trait anger and anger rumination.Highlights► We examined the influence of anger-associated rumination on perceived social well-being in daily life. ► We distinguished between hostile versus nonhostile goals that people pursue with their rumination following anger incidents. ► Hostile goal pursuit per se did not affect perceived social well-being. ► Impairment of social well-being following hostile rumination was moderated by trait anger.
    Personality and Individual Differences 10/2011; 51(6):769-774. DOI:10.1016/j.paid.2011.06.030 · 1.86 Impact Factor
  • Diabetologie und Stoffwechsel 05/2011; 6(S 01). DOI:10.1055/s-0031-1277333 · 0.31 Impact Factor
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    ABSTRACT: In this study, we examined the relationship between discrepancies between desired and received support and subjective well-being, as indicated by negative affect and perceived stress, in daily life. Participants were 30 undergraduates who were equipped with hand-held computers for seven days. Results showed that underprovision of support predicted lower well-being, whereas overprovision was related to higher well-being, suggesting a linear relationship. Emotional support proved to be more influential than practical and informational support. In contrast to previous research, perceived social support turned out to be unrelated to well-being in daily life.
    Journal of Health Psychology 03/2011; 16(4):621-31. DOI:10.1177/1359105310385366 · 1.88 Impact Factor
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    ABSTRACT: The article presents two studies done with the Anger-Related Reactions and Goals Inventory (ARGI) combining the assessment of functional and dysfunctional anger-related reactions with the goals that people pursue in regulating interpersonal anger. Study 1 ( N = 756) corroborated the questionnaire’s psychometric properties and factorial structure. Correlations with indicators for psychosocial well-being, trait anger, and the Big Five dimensions were largely in line with our predictions. Study 2 documented the convergence between self-reports ( N = 104) and reports of two knowledgeable informants ( N = 188), in particular for the dysfunctional reactions. We conclude that the ARGI is a reliable and valid questionnaire that taps into facets of anger regulation that are of high relevance for research on the consequences of anger for health and well-being. (PsycINFO Database Record (c) 2012 APA, all rights reserved)
    Journal of Individual Differences 01/2011; 32(1):1-13. DOI:10.1027/1614-0001/a000030 · 0.83 Impact Factor
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    ABSTRACT: Resting heart rate variability (HRV) can serve as an index of self-regulatory strength. In the present study we tested the hypotheses that HRV, indexing adaptive self-regulation, is associated with subjective well-being, and that this association is mediated by the habitual use of strategies of emotion regulation that involve executive functions. In addition to measuring heart rate at rest, subjective well-being – as indicated by positive habitual mood and satisfaction with life – and habitual emotion regulation were assessed via self-reports. The findings were largely consistent with our predictions. HRV was positively associated with cheerfulness and calmness, and these effects were mediated by executive emotion regulation. Mediated by these strategies, HRV was also associated with satisfaction with life. Together, the results support the use of HRV as an index of self-regulatory strength.
    Personality and Individual Differences 11/2010; 49(7):723-728. DOI:10.1016/j.paid.2010.06.015 · 1.86 Impact Factor

Publication Stats

523 Citations
175.60 Total Impact Points

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Institutions

  • 2012–2014
    • Johannes Gutenberg-Universität Mainz
      • Institute of Psychology
      Mayence, Rheinland-Pfalz, Germany
  • 2006–2013
    • University of Greifswald
      • Institute of Psychology
      Greifswald, Mecklenburg-Vorpommern, Germany