Miguel A Sanjoaquin

Publications (5)16.98 Total impact

• Article: Menopausal hormone therapy and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition.

  Konstantinos K Tsilidis, Naomi E Allen, Timothy J Key, Miguel A Sanjoaquin, Kjersti Bakken, Franco Berrino, Agnès Fournier, Eiliv Lund, Kim Overvad, Anja Olsen, [......], Carlos A González, María-José Sánchez, Maria-Dolores Chirlaque, Aurelio Barricarte, Miren Dorronsoro, Kay-Tee Khaw, Sheila A Rodwell, Teresa Norat, Dora Romaguera, Elio Riboli
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  ABSTRACT: Menopausal hormone therapy (HT) may influence colorectal cancer risk. A total of 136,275 postmenopausal women from the European Prospective Investigation into Cancer and Nutrition were followed for an average of 9 years, during which time 1,186 colorectal cancers were diagnosed. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models stratified by center and age, and adjusted for body mass index, smoking, diabetes, physical activity and alcohol consumption. Compared to never use of HT at study enrollment, current use of estrogen-only (HR, 1.02; 95% CI, 0.79-1.31) or estrogen plus progestin (HR, 0.94; 95% CI, 0.77-1.14) was not significantly associated with the risk of colorectal cancer, and these associations did not vary by recency, duration, route of administration, regimen or specific constituent of HT. Our results show no significant association of estrogen-only or estrogen plus progestin therapy with colorectal cancer risk.
  International Journal of Cancer 04/2011; 128(8):1881-9. · 5.44 Impact Factor
• Article: Assessing genuine parents-offspring trios for genetic association studies.

  Yik Y Teo, Andrew E Fry, Miguel A Sanjoaquin, Bonnie Pederson, Kerrin S Small, Kirk A Rockett, Dominic P Kwiatkowski, Taane G Clark
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  ABSTRACT: Family-based association tests such as the transmission disequilibrium test (TDT) are dependent on the successful ascertainment of true nuclear family trios. Relationship misspecification inevitably occurs in a proportion of trios collected for genotyping which undetected can lead to a loss of power and increased Type I error due to biases in over-transmission of common alleles. Here, we introduce a method for evaluating the authenticity of nuclear family trios. Operating in a Bayesian framework, our approach assesses the extent of pedigree inconsistent genotype configurations in the presence of genotyping errors. Unlike other approaches, our method: (i) utilizes information from three individuals collectively (the whole trio) rather than consider two independent pairwise relationships; (ii) down-weighs SNPs with poor performance; (iii) does not require the user to pre-define a rate of genotyping error, which is often unknown to the user and seldom fixed across the different SNPs considered which available methods unrealistically assumed. Simulation studies and comparisons with a real set of data showed that our approach is more likely to correctly identify the presence of true and misspecified trios compared to available software, accurately infers the extent of relationship misspecification in a trio and accurately estimates the genotyping error rates. Assessing relationship misspecification depends on the fidelity of the genotype data used. Available algorithms are not optimised for genotyping technology with varying rates of errors across the markers. Through our comparison studies, our approach is shown to outperform available methods for assessing relationship misspecifications.
  Human Heredity 11/2008; 67(1):26-37. · 1.79 Impact Factor
• Article: Colorectal cancer incidence, mortality and survival in South-east England between 1972 and 2001.

  Miguel A Sanjoaquin, Babak Choodari-Oskooei, Catherine Dolbear, Venkata Putcha, Ashu Sehgal, Tim J Key, Henrik Møller
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  ABSTRACT: We report incidence, mortality and survival from colorectal cancer in South-east England using data from 162,022 incident cases and 97,697 deaths collected between 1972 and 2001 at the Thames Cancer Registry, which currently covers 14 million people. Overall, there was an increase in the incidence of colorectal cancer among men aged 50 years and over, and a decrease among the youngest age groups. In women, there was a clear decrease in incidence among those aged less than 60 years but a slight increase among those aged 60-79 years. Furthermore, there has been a steady decrease in mortality for all ages, larger in women than in men, and an increase in the 10-year relative survival for both sexes from just over 30% among those followed-up during 1981-1986 to just over 45% among those followed-up during 1997-2001.
  European Journal of Cancer Prevention 03/2007; 16(1):10-6. · 2.13 Impact Factor
• Article: Folate intake and colorectal cancer risk: a meta-analytical approach.

  Miguel A Sanjoaquin, Naomi Allen, Elisabeth Couto, Andrew W Roddam, Timothy J Key
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  ABSTRACT: Adequate consumption of folate may reduce the risk of colorectal cancer. We performed a meta-analysis of 7 cohort and 9 case-control studies that examined the association between folate consumption and colorectal cancer risk. In cohort studies, the association between folate consumption and colorectal cancer risk was stronger for dietary folate (folate from foods alone; relative risk for high vs. low intake = 0.75; 95% CI = 0.64-0.89) than for total folate (folate from foods and supplements; relative risk for high vs. low intake = 0.95; 95% CI = 0.81-1.11) and there was no significant heterogeneity between studies. There was significant heterogeneity between case-control studies. These results offer some support for the hypothesis that folate has a small protective effect against colorectal cancer but confounding by other dietary factors cannot be ruled out.
  International Journal of Cancer 03/2005; 113(5):825-8. · 5.44 Impact Factor
• Article: Nutrition and lifestyle in relation to bowel movement frequency: a cross-sectional study of 20630 men and women in EPIC-Oxford.

  Miguel A Sanjoaquin, Paul N Appleby, Elizabeth A Spencer, Timothy J Key
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  ABSTRACT: To investigate the relationships between nutritional and lifestyle factors and bowel movement frequency. Cross-sectional analysis using data from a prospective study. Mean numbers of bowel movements were calculated in relation to a range of factors. In addition, individuals were categorised according to frequency of bowel movements: fewer than 7 per week ('less than daily') versus 7 or more per week ('daily'), and odds ratios were calculated from logistic regression models. Results for each factor were adjusted for the other factors under consideration. The European Prospective Investigation into Cancer and Nutrition, Oxford cohort (EPIC-Oxford), UK. In total, 20630 men and women aged 22-97 years at recruitment. Thirty per cent of the subjects were vegetarians or vegans. Women had fewer bowel movements on average than men, and were less likely to have daily bowel movements. Mean bowel movement frequency was higher in vegetarians (10.5 in men, 9.1 in women) and especially in vegans (11.6 in men, 10.5 in women) compared with participants who ate meat (9.5 in men, 8.2 in women). There were also significant positive associations between bowel movement frequency and body mass index (BMI), intakes of dietary fibre and non-alcoholic fluids, for both men and women. Vigorous exercise was positively associated with bowel movement frequency in women although results for men were less clear. Alcohol intake was positively associated with bowel movement frequency in men but not in women. Being vegetarian and especially vegan is strongly associated with a higher frequency of bowel movements. Moreover, having a high intake of dietary fibre and fluids and a high BMI are associated with an increase in frequency of bowel movements.
  Public Health Nutrition 03/2004; 7(1):77-83. · 2.17 Impact Factor