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ABSTRACT: Our institution established a new treatment facility for carbon ion beam scanning therapy in 2010. The major advantages of scanning beam treatment compared to the passive beam treatment are the following: high dose conformation with less excessive dose to the normal tissues, no bolus compensator and patient collimator/multi-leaf collimator, better dose efficiency by reducing the number of scatters. The new facility was designed to solve several problems encountered in the existing facility, at which several thousand patients were treated over more than 15 years. Here, we introduce the patient handling system in the new treatment facility. The new facility incorporates three main systems, a scanning irradiation system (S-IR), treatment planning system (TPS), and patient handling system (PTH). The PTH covers a wide range of functions including imaging, geometrical/position accuracy including motion management (immobilization, robotic arm treatment bed), layout of the treatment room, treatment workflow, software, and others. The first clinical trials without respiratory gating have been successfully started. The PTH allows a reduction in patient stay in the treatment room to as few as 7 min. The PTH plays an important role in carbon ion beam scanning therapy at the new institution, particularly in the management of patient handling, application of image-guided therapy, and improvement of treatment workflow, and thereby allows substantially better treatment at minimum cost.
Journal of Applied Clinical Medical Physics 01/2012; 13(6):3926. · 1.29 Impact Factor
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Takuji Furukawa,
Taku Inaniwa,
Shinji Sato,
Toshiyuki Shirai,
Yuka Takei,
Eri Takeshita,
Kota Mizushima,
Yoshiyuki Iwata,
Takeshi Himukai,
Shinichiro Mori,
Shigekazu Fukuda,
Shinichi Minohara,
Eiichi Takada, Takeshi Murakami,
Koji Noda
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ABSTRACT: A project to construct a new treatment facility, as an extension of the existing HIMAC facility, has been initiated for the further development of carbon-ion therapy at NIRS. This new treatment facility is equipped with a 3D irradiation system with pencil-beam scanning. The challenge of this project is to realize treatment of a moving target by scanning irradiation. To achieve fast rescanning within an acceptable irradiation time, the authors developed a fast scanning system.
In order to verify the validity of the design and to demonstrate the performance of the fast scanning prior to use in the new treatment facility, a new scanning-irradiation system was developed and installed into the existing HIMAC physics-experiment course. The authors made strong efforts to develop (1) the fast scanning magnet and its power supply, (2) the high-speed control system, and (3) the beam monitoring. The performance of the system including 3D dose conformation was tested by using the carbon beam from the HIMAC accelerator.
The performance of the fast scanning system was verified by beam tests. Precision of the scanned beam position was less than +/-0.5 mm. By cooperating with the planning software, the authors verified the homogeneity of the delivered field within +/-3% for the 3D delivery. This system took only 20 s to deliver the physical dose of 1 Gy to a spherical target having a diameter of 60 mm with eight rescans. In this test, the average of the spot-staying time was considerably reduced to 154 micros, while the minimum staying time was 30 micros.
As a result of this study, the authors verified that the new scanning delivery system can produce an accurate 3D dose distribution for the target volume in combination with the planning software.
Medical Physics 11/2010; 37(11):5672-82. · 2.83 Impact Factor
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Koji Noda,
Takuji Furukawa,
Takashi Fujisawa,
Yoshiyuki Iwata,
Tatsuaki Kanai,
Mitsutaka Kanazawa,
Atsushi Kitagawa,
Masataka Komori,
Shinichi Minohara, Takeshi Murakami,
Masayuki Muramatsu,
Shinji Sato,
Yuka Takei,
Mutsumi Tashiro,
Masami Torikoshi,
Satoru Yamada,
Ken Yusa
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ABSTRACT: The first clinical trial with carbon beams generated from HIMAC was conducted in June 1994. The total number of patients treated as of December 2006 was in excess of 3,000. In view of the significant growth in the number of protocols, the Japanese government gave its approval for carbon-ion therapy at NIRS as an advanced medical technology in 2003. The impressive advances of carbon-ion therapy using HIMAC have been supported by high-reliability operation and by advanced developments of beam-delivery and accelerator technologies. Based on our ten years of experience with HIMAC, we recently proposed a new accelerator facility for cancer therapy with carbon ions for widespread use in Japan. The key technologies of the accelerator and beam-delivery systems for this proposed facility have been under development since April 2004, with the main thrust being focused on downsizing the facility for cost reduction. Based on the design and R&D studies for the proposed facility, its construction was begun at Gunma University in April 2006. In addition, our future plans for HIMAC also include the design of a new treatment facility. The design work has already been initiated, and will lead to the further development of therapy using HIMAC. The following descriptions give a summary account of the new accelerator facility for cancer therapy with carbon ions and of the new treatment facility at HIMAC.
Journal of Radiation Research 01/2007; 48 Suppl A:A43-54. · 1.68 Impact Factor
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ABSTRACT: A tissue-equivalent proportional counter (TEPC) has been used as a dosimeter in mixed radiation fields. Since it does not measure LET directly, the response function must be characterized in order to estimate quality factor and thus equivalent dose for the incident radiation. The objectives of this study were to measure the response of a spherical TEPC for different high-energy heavy ions (HZE) having similar velocity and to determine how quality factors can be determined. Data were obtained at the HIMAC heavy ion accelerator for (4)He and (12)C at 220 +/- 5 MeV/nucleon (beta = 0.59) and (12)C, (16)O, (28)Si and (56)Fe at 376 +/- 15 MeV/nucleon (beta = 0.70). A particle spectrometer recorded the charge and position of each incident beam particle. Events with low energy deposition were observed for particles that passed through the wall of the TEPC but not through the sensitive volume. The frequency averaged lineal energy, y(f), was always less than the LET of the incident particles. The dose averaged lineal energy, y(D), was approximately equal to LET for particles with LET greater than 10 keV/mum, whereas y(D) was larger than LET for the lighter particles with lower LET. Part of this effect is due to detector resolution and energy straggling that increases the variance of the response function. Although the TEPC is not a LET spectrometer, it can provide real time measurements of dose and provide estimates of quality factors for HZE particles using averaged values of lineal energy.
Radiation Measurements 11/2006; 4179(9-10):1227-1234. · 1.18 Impact Factor
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ABSTRACT: The effective doses and attenuation lengths for concrete and iron were measured for the design of heavy ion facilities. Neutrons were produced through the reaction of copper, carbon, and lead bombarded by carbon ions at 230 and 400 MeV.A, neon ions at 400 and 600 MeV.A, and silicon ions at 600 and 800 MeV.A. The detectors used were a Linus and a Andersson-Braun-type rem counter and a detector based on the activation of a plastic scintillator. Representative effective dose rates (in units of 10(-8) microSv h(-1) pps(-1) at 1 m from the incident target surface, where pps means particles per second) and the attenuation lengths (in units of m) were 9.4 x 10(4), 0.46 for carbon ions at 230 MeV.A; 8.9 x 10(5), 0.48 for carbon ions at 400 MeV.A; 9.3 x 10(5), 0.48 for neon ions at 400 MeV.A; 3.8 x 10(6), 0.50 for neon ions at 600 MeV.A; 3.9 x 10(6), 0.50 for silicon ions at 600 MeV.A; and 1.1 x 10(7), 0.51 for silicon ions at 800 MeV.A. The attenuation provided by an iron plate approximately 20 cm thick (nearly equal to the attenuation length) corresponded to that of a 50-cm block of concrete in the present energy range. Miscellaneous results, such as the angular distributions of the neutron effective dose, narrow beam attenuation experiments, decay of gamma-ray doses after the bombardment of targets, doses around an irradiation room, order effects in the multi-layer (concrete and iron) shielding, the doses from different targets, the doses measured with a scintillator activation detector, the gamma-ray doses out of walls and the ratio of the response between the Andersson-Braun-type and the Linus rem counters are also reported.
Health Physics 06/2005; 88(5):469-79. · 1.68 Impact Factor
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ABSTRACT: The response of a tissue-equivalent proportional counter (TEPC) to different ions having a similar linear energy transfer (LET) has been studied. Three ions, 14N, 20Ne and 28Si, were investigated using the HIMAC accelerator at the National Institute of Radiological Sciences at Chiba, Japan. The calculated linear energy transfer (LET( infinity )) of all ions was 44 +/- 2 keV/microm at the sensitive volume of the TEPC. A particle spectrometer was used to record the charge and position of each incident beam particle. This enabled reconstruction of the location of the track as it passed though the TEPC and ensured that the particle survived without fragmentation. The spectrum of energy deposition events in the TEPC could be evaluated as a function of trajectory through the TEPC. The data indicated that there are many events from particles that did not pass through the sensitive volume. The fraction of these events increased as the energy of the particle increased due to changes in the maximum energy of the delta rays. Even though the LET of the incident particles was nearly identical, the frequency-averaged lineal energy, y(F), as well as the dose-averaged lineal energy, y(D), varied with the velocity of the incident particle. However, both values were within 15% of LET in all cases.
Radiation Research 02/2004; 161(1):64-71. · 2.68 Impact Factor
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Davide Mancusi,
Lembit Sihver,
Katarina Gustafsson,
Chiara La Tessa,
Stephen B. Guetersloh,
Cary J. Zeitlin,
Jack Miller,
Lawrence H. Heilbronn,
Koji Niita,
Tatsuhiko Sato,
Hiroshi Nakashima, Takeshi Murakami,
Yoshiyuki Iwata
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ABSTRACT: The PHITS (Particle and Heavy Ion Transport System) code is a three-dimensional Monte Carlo code that is able to simulate the transport of nuclei and other particles in complicated geometries and calculate fluxes, doses, energy-deposition distributions and many other observables. Among its many possible fields of application, it can be used e.g. to design and optimise radiation shields for space vessels. However, the reliability of the predictions of the code depends directly on the certified accuracy of the code components, i.e. the models the code uses to estimate the quantities necessary for the transport calculation. As a part of a comprehensive benchmarking program, we have investigated the possibility of using PHITS to calculate partial charge-changing cross sections and we have compared the results with measurements performed by some of us (CZ, LH, JM, SG). The results, although limited, suggest that the current reaction-cross-section models might be inadequate for use in space radioprotection; we therefore claim the need for a thorough benchmarking of the models and for new reaction-cross-section measurements and experimental techniques.
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms.
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Yasushi Iseki,
Hideyuki Mizuno,
Yasuyuki Futami,
Takehiro Tomitani,
Tatsuaki Kanai,
Mitsutaka Kanazawa,
Atsushi Kitagawa, Takeshi Murakami,
Teiji Nishio,
Mitsuru Suda,
Eriko Urakabe,
Akira Yunoki,
Hirotaka Sakai
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ABSTRACT: A positron camera, consisting of a pair of Anger-type scintillation detectors, has been developed to verify ranges by using positron emitter beams. Each detector head is equipped with a NaI(Tl) crystal (diameter: , thickness: ) for high detection efficiency. To get a low counting rate for this application, the electric circuit was designed for flexibility in measurement and analysis by software. The energy and position were calibrated for high measurement accuracy. A spatial resolution of in FWHM within a region (field of view) and a linear response of a standard deviation within a region were obtained. The camera was designed so as to measure the ranges within an accuracy of under a dose limitation (about ) to reduce the safety margin for the irradiation field, and it met the required characteristics.
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment.
