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ABSTRACT: In recent years, emerging data support the concept of endothelial dysfunction in the course of age-related macular degeneration (AMD). Circulating endothelial cells (CECs) are desquamated mature cells that have detached from the intimal monolayer in response to endothelial injury. In this study we sought to explore the potential role of endothelial dysfunction in pathogenesis of AMD by measuring the concentration of CECs in peripheral blood of AMD patients.
Peripheral blood samples from 31 patients with diagnosed dry AMD and 46 patients with neovascular AMD were collected. Forty six, age- and sex-matched volunteers without AMD were enrolled as a control group. CECs were counted and analyzed by flow cytometry.
Multivariate analyses of patients and controls adjusted for age, gender, presence of ischemic heart disease, hypertension and smoking (current or past) revealed that both wet (beta = +0.45, p = 0.0003) and dry (beta = +0.28, p = 0.027) forms of AMD are independent factors associated with higher number of CECs.
Our results suggest that there is an endothelial alteration accompanying AMD. Increased numbers of CECs AMD patients reflect a severe vascular disturbance and may contribute to the disease process. These findings can help expand our knowledge of the pathogenic mechanisms of AMD and may be relevant to the potential treatment of this disease.
Klinika oczna 01/2011; 113(7-9):228-32.
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ABSTRACT: The radiotherapy is worth to remember in the most progression causes of AMD, when there is no possibility for application the modern methods of the treatment. We present cause of patient with bilateral advanced changes and low visual acuity in course AMD, who had applied rtg therapy and laser fotocoagulation. The right eye was radiated with foton beam energy 10 MeV using linear accelerator. Dosage of 9 Gy was delivered in 3 fractions through 5 days. In right eye we observed increase of visual acuity from 2/50 before treatment to 3/50 after 12 months, and 0.1 after the 48 months of radiation. The visual acuity in the left eye decreased from 0.2 to 2/50 after the 48 months. The improvement of acuity vision after rtg therapy allowed the patient self-dependence life.
Klinika oczna 02/2008; 110(1-3):82-7.
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ABSTRACT: To evaluate the influence of AcrySofNatural SN 60 AT lens on the progression of age-related macular degeneration (AMD).
Forty eyes of 20 patients (12 women and 8 men, mean age of 74 years) with bilateral cataract and age-related macular degeneration were analyzed. In both eyes (3 weeks interval) cataract surgery with intraocular lens implantation was performed. In one eye, the lens with blue light blocking filter 400-500 nm (AcrySof Natural SN 60 AT) was implanted. In the opposite eye, which served as a control, standard (AcrySof SA 60 AT) lens was implanted. To estimate AMD progression after bilateral surgery, the routine ophthalmic examination, fluorescein angiography and multifocal ERG results were performed. After mean 18 months obtained results from eye with AcrySof Natural were compared to the results from the opposite eye.
After surgery (mean follow-up--18 months) in eyes with implantations of AcrySof Natural and standard lenses there were no significant differences in routine ophthalmic examination and fluorescein angiography results. In eyes with implanted AcrySofNatural SN 60 AT lens, in mfERG a significant decrease of central retinal function was observed (p < or = 0.05). In eyes with standard AcrySof lens in mfERG statistical differences of analyzed parameters were not found.
The results of our study suggest lack of protective influence of AcrySofNatural lens on the AMD progression. Further investigation on the larger group of patients should be performed to confirm our initial results.
Annales Academiae Medicae Stetinensis 01/2007; 53 Suppl 1:43-7; discussion 47-8.
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ABSTRACT: PURPOSE: The aim of the study was to evaluate factors possibly effecting the posterior capsule opacification (PCO), after extra-capsular cataract extraction with the posterior chamber intra-ocular lens (IOL) implantation. Age of patients, refractive errors, technique of cataract extraction, intra- and postoperative complications and coexisting diseases were taken into consideration. In 1992-98 posterior laser Nd:YAG capsulotomy was performed in 222 eyes of 222 patients (134 women and 88 men) previously operated in 1st and IInd Eye Clinic. PCO occurred in 5.8% patients, who underwent cataract extraction in this period, in 5.7% patients operated with phacoemulsification method and in 5.8% patients where extra-capsular cataract extraction with nucleus expulsion was performed. PCO was diagnosed in 12.7% patients at the age below 30, in 17% aged 31-40, in 7.8% aged 41-55 and in 5.1% patients older than 55 years. Among the patients, who developed PCO, in 6.3% myopia was present, in 8% primary open angle glaucoma, 16.6% were treated for diabetes mellitus. In 7.6% eyes the intra-operative cortical clean up was not efficient. CONCLUSION: PCO occurred in young patients (under 40) twice as often as in the other groups of age. Technique of cataract extraction had an influence on the incidence of PCO as well.
Klinika oczna 02/2004; 106(1-2):19-22.
