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ABSTRACT: To assess the efficacy and safety of a new oral rehydration solution (ORS) with improved flavour in the management of children with acute gastroenteritis (AGE).
Children 4 to 48 months of age with AGE (≥3 loose or watery stools per day for >1 but <5 days) with mild-to-moderate dehydration (3% to 9% loss of body weight) according to the World Health Organization criteria randomly received regular hypotonic ORS (Na 60 mmol/L, glucose 78 mmol/L) or the same hypotonic ORS with an apple taste.
Of the 147 children randomized, 130 (88.4%) were available for intention-to-treat analysis. The proportion of children with the resolution of signs of dehydration in the experimental group compared with the control group was similar at 24 h (49/63 vs. 57/67, respectively, p = 0.28). There were also no significant differences in adequate weight gain (p = 0.48) and urine production at 24 h (p = 0.95) between groups. There were no differences between groups in any of the secondary outcome measures, including ORS intake. No adverse events were observed in the study groups.
In an outpatient setting, there was no difference in efficacy between the study products. Both ORSs were equally effective and may be used interchangeably.
Acta Paediatrica 08/2012; 101(10):e458-64. · 2.07 Impact Factor
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ABSTRACT: To evaluate the efficacy and safety of zinc in the treatment of acute gastroenteritis (AGE) in children in Poland.
Children aged 3 to 48 months with AGE were enrolled in a randomized, double-blind, placebo-controlled trial in which they received zinc sulfate (10 or 20 mg/day depending on age) or placebo for 10 days. A total of 141 of 160 children recruited were available for intention-to-treat analysis. The primary outcome was the duration of diarrhea.
In the experimental group (n = 69) compared with the control group (n = 72), there was no significant difference in the duration of diarrhea (P > .05). Similarly, there was no significant difference in the groups in secondary outcome measures such as stool frequency on days 1, 2, and 3, vomiting frequency, intravenous fluid intake, and the number of children with diarrhea lasting >7 days.
Children living in a country where zinc deficiency is rare do not appear to benefit from the use of zinc in the treatment of AGE.
The Journal of pediatrics 12/2010; 157(6):984-988.e1. · 4.02 Impact Factor
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ABSTRACT: To determine the efficacy of a combination of Bifidobacterium longum PL03, Lactobacillus rhamnosus KL53A and Lactobacillus plantarum PL02 for the prevention of antibiotic-associated diarrhea in children.
Seventy-eight children (age: 5 months to 16 years) with otitis media, and/or respiratory tract infections, and/or urinary tract infections were enrolled in a double-blind randomized control trial in which they received standard antibiotic treatment plus a food supplement containing 10(8) colony-forming units of B. longum, L. rhamnosus and L. plantarum (n = 40) or a placebo (n = 38) orally twice daily for the duration of antibiotic treatment.
Patients receiving probiotics had a similar rate of diarrhea (> or =3 loose or watery stools/day for > or =48 h occurring during or up to 2 weeks after the antibiotic therapy) as those receiving placebo (relative risk 0.5, 95% CI 0.06-3.5). The mean number of stools per day was significantly lower in the experimental group (mean difference -0.3 stool/day, 95% CI -0.5 to -0.07). No adverse events were reported.
The administration of the 3 probiotics did not significantly alter the rate of diarrhea, although it reduced the frequency of stools per day. As the overall frequency of diarrhea was surprisingly low, these results should be interpreted with caution.
Digestion 09/2008; 78(1):13-7. · 2.05 Impact Factor
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ABSTRACT: Lactobacillus rhamnosus (573L/1-3) strains are considered effective in the treatment of rotaviral diarrhoea in children. The colonisation of the gastrointestinal (G.I.) tract by the Lactobacillus rhamnosus strains and the determining factors are discussed reporting data of a prospective, double-blinded, placebo-controlled randomized study in children between the 2nd month and 6th year of life with acute diarrhoea lasting not longer than 5 days. The examined strains were detected in 37/46 (80.43%) patients after 5 days and in 19/46 (41.3%) patients after 14 days since the start of the treatment. L. rhamnosus 573L/1 strain colonised the G.I. tract more persistently. L. rhamnosus strains are effective in colonising the G.I. tract during acute diarrhoea. Persistence of colonisation is dependent on the properties of administered probiotic strains.
Digestive and Liver Disease 01/2007; 38 Suppl 2:S274-6. · 3.05 Impact Factor
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ABSTRACT: Normal microflora of the digestive tract plays an important role in maintaining competence of the immune system. Imbalance of the flora may lead to the development of either diseases related to overgrowth of its selected constituents (post-antibiotic diarrhoea, travellers' diarrhoea or infection by external pathogens--rotavirus diarrhoea) or diseases resulting from altered immunological response (atopy, inflammatory bowel disease, neoplasmas). It is believed that application of probiotics may restore proper composition and functions of the microflora and thus bring new perspectives into prevention and treatment of these illnesses. Prospective studies on mechanisms of the probiotic activities may enable their new medical applications.
Wiadomości lekarskie (Warsaw, Poland: 1960) 02/2005; 58(11-12):640-6.
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Leszek Szenborn,
Jerzy Pejcz, Henryk Szymański,
Waldemar Krajewski,
Jarosław Narecki,
Renata Filipczak,
Zdzisława Piotrowska-Gede,
Anna Widlińska-Podlacha,
Joanna Iliew-Kedzia,
Jolanta Tuchcińska-Sowa, [......],
Ewa Lewczyk,
Joanna Sapota,
Imad Ramzzi-Samaan,
Elzbieta Kowalska,
Andrzej Kałas,
Danuta Sidor,
Leszek Michniewicz,
Eleonora Kozieł,
Sabina Kobylińska,
Krzysztof Kobyliński
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ABSTRACT: Croup syndrome is an urgent and frequent reason for hospitalization of children.
632 children with croup syndrome (422 boys and 210 girls aged 2 months-17 years) admitted to 15 pediatric departments in Lower Silesia were prospectively observed for 12 months (from April 2001 to March 2002). We conducted prospective survey of clinical and laboratory data from all study centers.
Following diagnoses were accepted as the croup syndrome: subglottic laryngitis in 482 patients (75.4%), laryngotracheobronchitis in 75 (11.8%), laryngitis in 50 (7.8%) and epiglottitis in 20 children (3%). The most severe course was observed in children with epiglottitis. Four of them required airway intervention and had endotracheal intubation. H. influenzae b was cultured from blood of one patient. The most cases of epiglottitis occurred in the 3rd year of life (45%).
1. The most common reason of croup was subglottic laryngitis. 2. Epiglottitis was rare with serious course of disease; frequency was comparable with the frequency seen in European countries before the implementation of Hib vaccine. The routine use of Hib vaccine in Poland may prevent from children life threatening epiglottis cases.
Przegla̧d lekarski 02/2004; 61(5):457-62.
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Jerzy Pejcz,
Leszek Szenborn, Henryk Szymański,
Waldemar Krajewski,
Jarosław Narecki,
Renata Filipczak,
Zdzisława Piotrowska-Gede,
Anna Widlińska-Podlacha,
Joanna Iliew-Kedzia,
Jolanta Tuchcińska-Sowa, [......],
Joanna Sapota,
Imad Ramzzi-Samaan,
Elzbieta Kowalska,
Andrzej Kałas,
Ewa Lewczyk,
Danuta Sidor,
Leszek Michniewicz,
Eleonora Kozieł,
Sabina Kobylińska,
Krzysztof Kobyliński
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ABSTRACT: The aim of the study was to estimate treatment practice in hospital management of croup syndrome (laryngitis subglottica) in children in Poland.
During the period of 12 months, we have prospectively observed 482 children with croup syndrome admitted to 15 pediatric departments in Lower Silesia (south-west region of Poland). Data concerning epidemiology, clinical course and treatment were collected from uniform observation cards. There were 326 boys and 156 girls aged between 2 and 174 months in our study.
Among 482 observed children, received glucocorticoids 424 (88%) mainly parenteral, L-epinephrine--211 (43.8%), mist therapy--241 (50%), antihistamines--308 (63.9%), antibiotics--280 (58.1%). Children treated with antibiotics were younger (p=0.0316), their temperature, amount of leukocytes and value of C-reactive protein was higher when compared with those not treated (p=0.0002; p=0.0081, p=0.0172 respectively).
Children in Lower Silesia with croup syndrome were treated in agreement with recent standards with glucocorticoids and/or epinephrine. There was an excessive usage of antihistamines which have no established treatment role. It seems that in many cases antibiotic treatment could have been avoided.
Przegla̧d lekarski 02/2004; 61(5):463-6.
