R A Jastania

University of Toronto, Toronto, Ontario, Canada

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Publications (2)3.2 Total impact

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    ABSTRACT: The diagnosis of double adenomas of the pituitary can be very complex and is usually suspected on histological assessment of a specimen and confirmed by immunohistochemical and ultrastructural studies. The most commonly applied technique is currently immunohistochemical staining to localize the six pituitary hormones. Application of this technique may fail to identify double adenomas when hormone immunoreactivity is weak or absent in one or both cell populations. We examined specimens from eight patients diagnosed with double adenomas over a 15-yr period. We tested the ability to detect the difference in the two adenomas in each case using three immunostains for the pituitary transcription factors Pit-1, T-pit, and SF-1. We conclude that immunohistochemical localization of the transcription factors Pit-1, T-pit, and SF-1 accurately detects and classifies the distinct cytodifferentiation of double adenomas of the pituitary.
    Endocrine Pathology 02/2005; 16(3):187-94. · 1.60 Impact Factor
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    ABSTRACT: We report a case of granulomatous hypophysitis with an unusual pathologic finding of psammoma bodies. This finding has not previously been described in the literature. The diagnostic implications of this finding are complex, and the pathogenesis of psammoma body formation in this idiopathic disorder remains unknown.
    Endocrine Pathology 02/2004; 15(4):359-63. · 1.60 Impact Factor

Publication Stats

13 Citations
3.20 Total Impact Points

Top Journals

Institutions

  • 2004–2005
    • University of Toronto
      • Department of Laboratory Medicine and Pathobiology
      Toronto, Ontario, Canada