Gianluca Granata

Second University of Naples, Caserta, Campania, Italy

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Publications (3)4.18 Total impact

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    ABSTRACT: Some haematological diseases are associated to an increased risk of thromboembolic events. We report a case of paroxysmal nocturnal haemoglobinuria (PNH) in which a cerebrovascular event represented the first clinical manifestation of disease. PNH is associated to thromboembolic events, generally of venous districts often involving unusual locations such as mesenteric vessels, sagittal veins, inferior vena cava and renal veins.To our knowledge arterial thrombotic episodes are rare and the involvement of arterial cerebral vessels is exceptional. Then, our case points out the importance of investigating about haematological disorders in all patients presenting with a stroke, in which the common predisposing conditions are excluded.
    Thrombosis Journal 11/2004; 2(1):10. · 1.31 Impact Factor
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    ABSTRACT: Primary cardiac lymphoma (PCL), defined as a lymphoma clinically mimicking cardiac disease, with the bulk of the tumor located intrapericardially, is extremely rare in immunocompetent patients. Clinical manifestations vary depending on sites of involvement in the heart and include chest pain, arrhythmias, pericardial effusion, and heart failure. Diagnosis is often difficult and may require invasive procedures; in some cases, diagnosis is not made until autopsy. Histologically, nearly all cases of PCL reported thus far have been of B-cell origin. In this report, we describe a case of PCL of T-cell origin in an adult immunocompetent patient, the second reported in the literature to the best of our knowledge, and provide a brief overview of the features of previously published PCL cases.
    Annals of Hematology 08/2004; 83(7):450-4. · 2.87 Impact Factor
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    ABSTRACT: 231 Lot of reports showed cancer acquired thrombophilia [1, 2], since Trousseau described this clinical associa-tion the first time [3]. Oncological disease, in fact, is the more common cause of acquired thrombophilia [4] and for this reason thromboembolic complications are fre-quent in cancer patients [5]. However, many pathways seem to be involved in pathophysiology of hypercoagu-lable state of cancer patients [6], so confirming venous thromboembolism is a multifactorial disease. Previous reports, in particular by Tiutrin et al and by De Lucia et al [7, 8], showed acquired thrombophilia of gastric cancer patients in advanced stage involving hypofibrinolysis and an acquired activated protein C resistance (APCr) respectively. In 2001 Di Micco et al [9] showed cancer acquired thrombophilia also in non advanced stage of gastric cancer patients. The aim of this study is to investigate APCr in nonmetastatic gas-tric cancer patients in order to explain thrombophilia in this stage of the disease. We selected 9 patients affected by nonmetastatic gastric cancer (8 males and 1 female, mean age 50 ± 8 years, 8 intestinal type and 1 diffuse type) and 10 healthy age matched subjects (8 males and 2 fe-males, mean age 49 ± 9 years) as control group. Abbreviations used: APCr — acquired activated protein C resis-tance; aPTT — activated partial thromboplastin time; F 1+2 — pro-thrombin fragment 1+2; FVL — factor V Leiden mutation; PT — prothrombin time. ÎÒÑÓÒÑÒÂÈÅ ÐÅÇÈÑÒÅÍÒÍÎÑÒÈ ÀÊÒÈÂÈÐÎÂÀÍÍÎÃÎ ÏÐÎÒÅÈÍÀ Ñ Ó ÁÎËÜÍÛÕ Ñ ÍÅÌÅÒÀÑÒÀÒÈ×ÅÑÊÈÌ ÐÀÊÎÌ AEÅËÓÄÊÀ Ï. Äè Ìèêêî*, Ã. Êàñòàëäî, Ã. Ãðàíàòà, A. Íèãëèî IV îòäåëåíèå âíóòðåííåé ìåäèöèíû, Âòîðîé óíèâåðñèòåò Íåàïîëÿ, Íåàïîëü, Èòàëèÿ Studies on thrombophilia of gastric cancer patients, in particular in nonmetastatic gastric cancer, are lacking in literature. Previous reports showed hypofibrinolysis in advanced gastric cancer patients and acquired activated protein C resistance in advanced gastric cancer patients ongoing chemotherapy. In 2001 Di Micco et al described thrombophilia of nonmetastatic gastric cancer patients for the first time, but without correlation with hypofibrino-lysis. Data of this report confirmed acquired thrombophilia of nonmetastatic gastric cancer patients but did not show acquired activated protein C resistance (APCr) in this stage of the disease. Key Words: hypercoagulable state, cancer acquired thrombophilia, gastric cancer, factor V Leiden.  ëèòåðàòóðå îòñóòñòâóþò äàííûå ïî èññëåäîâàíèþ òðîìáîôèëèè ó áîëüíûõ ðàêîì aeåëóäêà.  ïðåäûäóùèõ ñîîáùåíèÿõ óêàçûâàëîñü íà íàëè÷èå ãèïîôèáðèíîëèçà ó áîëüíûõ ñ ïðîãðåññèðóþùèì ðàêîì aeåëóäêà è ïðèîáðåòåííîé ðåçèñòåíòíîñòüþ àêòèâèðîâàííîãî ïðîòåèíà Ñ ó áîëüíûõ ñ ïðîãðåññèðóþùèì ðàêîì aeåëóäêà, êîòîðûì ïðîâîäèëè õèìèîòåðàïèþ.  2001 ã. Di Micco è ñîàâòîðû âïåðâûå îïèñàëè òðîìáîôèëèþ, íå êîððåëèðóþùóþ ñ ãèïîôèáðèíîëèçîì, ó áîëüíûõ c íåìåòàñòàòè÷åñêèì ðàêîì aeåëóäêà. Íàñòîÿùåå èññëåäîâàíèå ïîäòâåðaeäàåò íàëè÷èå ïðèîáðåòåííîé òðîìáîôèëèè ó áîëüíûõ ñ íåìåòàñòàòè÷åñêèì ðàêîì aeåëóäêà ïðè îòñóòñòâèè ïðèîáðåòåííîé ðåçèñòåíòíîñòè àêòèâèðîâàííîãî ïðîòåèíà Ñ (APCr) íà äàííîé ñòàäèè çàáîëåâàíèÿ. Êëþ÷åâûå ñëîâà: ñîñòîÿíèå ãèïåðêîàãóëÿöèè, òðîìáîôèëèÿ, ðàê aeåëóäêà, ôàêòîð V Ëåéäåíà.
    Experimental Oncology. 10/2003; 25:231-232.