[Show abstract][Hide abstract] ABSTRACT: Some haematological diseases are associated to an increased risk of thromboembolic events. We report a case of paroxysmal nocturnal haemoglobinuria (PNH) in which a cerebrovascular event represented the first clinical manifestation of disease. PNH is associated to thromboembolic events, generally of venous districts often involving unusual locations such as mesenteric vessels, sagittal veins, inferior vena cava and renal veins.
To our knowledge arterial thrombotic episodes are rare and the involvement of arterial cerebral vessels is exceptional. Then, our case points out the importance of investigating about haematological disorders in all patients presenting with a stroke, in which the common predisposing conditions are excluded.
[Show abstract][Hide abstract] ABSTRACT: Primary cardiac lymphoma (PCL), defined as a lymphoma clinically mimicking cardiac disease, with the bulk of the tumor located intrapericardially, is extremely rare in immunocompetent patients. Clinical manifestations vary depending on sites of involvement in the heart and include chest pain, arrhythmias, pericardial effusion, and heart failure. Diagnosis is often difficult and may require invasive procedures; in some cases, diagnosis is not made until autopsy. Histologically, nearly all cases of PCL reported thus far have been of B-cell origin. In this report, we describe a case of PCL of T-cell origin in an adult immunocompetent patient, the second reported in the literature to the best of our knowledge, and provide a brief overview of the features of previously published PCL cases.
Annals of Hematology 08/2004; 83(7):450-4. DOI:10.1007/s00277-003-0824-9 · 2.63 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Studies on thrombophilia of gastric cancer patients, in particular in nonmetastatic gastric cancer, are lacking in literature. Previous reports showed hypofibrinolysis in advanced gastric cancer patients and acquired activated protein C resistance in advanced gastric cancer patients ongoing chemotherapy. In 2001 Di Micco et al described thrombophilia of nonmetastatic gastric cancer patients for the first time, but without correlation with hypofibrinolysis. Data of this report confirmed acquired thrombophilia of nonmetastatic gastric cancer patients but did not show acquired activated protein C resistance (APCr) in this stage of the disease.