Luciano Signore

Publications of Luciano Signore

• [Development of an informatic model for monitoring and clinical and epidemiological evaluation of acute intoxication in Emergency Departments in Italy]

  Authors: Luciano Signore, Moira D'Urbano, Alessandro Russo

  Annali dell'Istituto superiore di sanità. 02/2006; 42(3):281-6.

  Data collection at Emergency Departments (ED), especially with regard to toxicological aspects, is usually incomplete; they further deteriorate following the recent diffusion of data processing andData collection at Emergency Departments (ED), especially with regard to toxicological aspects, is usually incomplete; they further deteriorate following the recent diffusion of data processing and retrieval systems, possibly different from region to region. The present paper deals with the setting of a computer program, specific for toxicological patients, easy to access from the general data collection system.

• [Peculiar features of childhood poisoning and in the maternal-fetal period]

  Authors: Alberto Marchi, Massimo Chiossi, Sergio Renier, Alberto Baratta, Patrizia Botarelli, Giovanni Cardoni, Giovanni Crichiutti, Barbara Cuomo, Liviana Da Dalt, Maria Di Marco [......] Marisa Vietti Ramus, Luciano Signore, Manuela Turbacci, Antonino Turrisi, Antonio Francesco, Maurizio Valenti, Antonio Vitale, Libero Zannino, Marco Knezevitch, Francesca Valent

  Annali dell'Istituto superiore di sanità. 02/2006; 42(3):318-24.

  Acute toxic exposures in childhood are quite a frequent event in Paediatric Emergency Medicine. Despite that, there are few papers about clinical toxicology in children, at least in Italy. This paperAcute toxic exposures in childhood are quite a frequent event in Paediatric Emergency Medicine. Despite that, there are few papers about clinical toxicology in children, at least in Italy. This paper is the first that takes into account both epidemiological aspects and clinical features of acute poisoning in children on a national basis. Collected data show the increased use of activated charcoal as a treatment and the use of the short stay observation unit as an appropriate answer to the real clinical situation, although some aspects are still controversial. It will be necessary to reconsider the whole matter widening the number of participating centres, so that the most controversial aspects may be clarified.

• Retention of CPR performance in anaesthetists.

  Authors: Federico Semeraro, Luciano Signore, Erga L Cerchiari

  Resuscitation. 01/2006; 68(1):101-8.

  The objective of this study was to evaluate retention of ALS knowledge and performance among anaesthesiologists, who, in Italy, respond to in-hospital emergencies as team leaders. METHODS: 47The objective of this study was to evaluate retention of ALS knowledge and performance among anaesthesiologists, who, in Italy, respond to in-hospital emergencies as team leaders. METHODS: 47 anaesthesiologists (23 consultants and 24 residents) were invited at one weeks notice to attend a re-evaluation session, 6 months after successful completion of an ERC ALS course. Knowledge retention was assessed by a multiple choice question test, and skills and management by evaluation of performance as team leader in one of the six standardized CAStest scenarios. During the performance, the timeliness of first defibrillation, completion of the three shock sequence, adrenaline (epinephrine) administration and intubation were recorded. Results were compared between consultants and residents. RESULTS: Compared to the results at the end of the ALS course, the percent of correct answers to the multiple choice question test decreased from 85.89 +/- 5.28% to 79.45 +/- 6.62% (P < 0.001), the number of candidates achieving a pass performance decreased from 47/47 to 30/47 (P < 0.001). Time to first defibrillation was 73.38 +/- 18.72 s, time for completion of the third defibrillation was 113.04 +/- 35.58 s and subsequent ALS interventions were very delayed or forgotten. Comparison between consultants and residents showed that consultants retained knowledge information better, skills decreased comparably in both groups and residents performed tasks faster. CONCLUSIONS: The significant decay of ALS skills 6 months post-ALS recorded among anaesthesiologists supports the need for periodical reinforcement during intervals before recertification.

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• High levels of morphine-6-glucuronide in street heroin addicts.

  Authors: Letizia Antonilli, Federico Semeraro, Carmen Suriano, Luciano Signore, Paolo Nencini

  Psychopharmacology. 12/2003; 170(2):200-4.

  RATIONALE: In the body, heroin is rapidly transformed to 6-acetylmorphine (6-AM) and then to morphine, that in turn is mainly metabolized to morphine-3-glucuronide (M3G) and, at lesser extent, toRATIONALE: In the body, heroin is rapidly transformed to 6-acetylmorphine (6-AM) and then to morphine, that in turn is mainly metabolized to morphine-3-glucuronide (M3G) and, at lesser extent, to morphine-6-glucuronide (M6G). Unlike M3G, M6G is a potent opioid agonist. Intravenous heroin abusers (IHU) are exposed to a wide array of drugs and contaminants that might affect glucuronidation. OBJECTIVES: We assessed plasma and urine concentrations of M3G and M6G in four groups of subjects: the first two included long-term IHU either exposed to street heroin ( n=8) or receiving a single IV injection of morphine ( n=4), while the other two groups included non-IHU patients receiving acute IV ( n=8) or chronic oral ( n=6) administrations of morphine. METHODS: After solid phase extraction plasma and urine concentrations of morphine metabolites were determined by HPLC analyses. RESULTS: M3G accounted for the greater part of morphine glucuronides detected in body fluids of non-IHU patients treated with morphine. This pattern of metabolism remained stable across 15 days of oral administration of incremental doses of morphine. In contrast, the two groups of IHU (street heroin taking or morphine-treated subjects) showed a reduction of blood and urine M3G concentrations in favor of M6G. Consequently, M6G/M3G ratio was significantly higher in the two IHU groups in comparison with the non-IHU groups. CONCLUSIONS: Chronic exposure to street heroin causes a relative increase in concentrations of the active metabolite, M6G. Since the pattern of M6G action seems closer to heroin than to morphine, the increased synthesis of M6G observed in IHU may prolong the narrow window of heroin effects.