[Show abstract][Hide abstract] ABSTRACT: Monte Carlo simulations of S-values have been carried out with the Geant4-DNA extension of the Geant4 toolkit. The S-values have been simulated for monoenergetic electrons with energies ranging from 0.1 keV up to 20 keV, in liquid water spheres (for four radii, chosen between 10 nm and 1 µm), and for electrons emitted by five isotopes of iodine (131, 132, 133, 134 and 135), in liquid water spheres of varying radius (from 15 µm up to 250 µm). The results have been compared to those obtained from other Monte Carlo codes and from other published data. The use of the Kolmogorov-Smirnov test has allowed confirming the statistical compatibility of all simulation results.
Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms 01/2014; 319:87-94. · 1.19 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Modeling the radio-induced effects in biological medium still requires accurate physics models to describe the interactions induced by all the charged particles present in the irradiated medium in detail. These interactions include inelastic as well as elastic processes. To check the accuracy of the very low energy models recently implemented into the GEANT4 toolkit for modeling the electron slowing-down in liquid water, the simulation of electron dose point kernels remains the preferential test. In this context, we here report normalized radial dose profiles, for mono-energetic point sources, computed in liquid water by using the very low energy "GEANT4-DNA" physics processes available in the GEANT4 toolkit. In the present study, we report an extensive intra-comparison of profiles obtained by a large selection of existing and well-documented Monte-Carlo codes, namely, EGSnrc, PENELOPE, CPA100, FLUKA and MCNPX.
Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine 02/2013; · 1.09 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: The Geant4-DNA project proposes to develop an open-source simulation software based and fully included in the general-purpose Geant4 Monte-Carlo simulation toolkit. The main objective of this software is to simulate biological damages induced by ionizing radiations at the cellular and sub-cellular scale. This project was originally initiated by the European Space Agency for the prediction of the deleterious effects of radiations that may affect astronauts during future long duration space exploration missions. In this paper, the Geant4-DNA collaboration presents an overview of the whole on-going project, including its most recent developments that are available in the Geant4 toolkit since December 2009 (release 9.3), as well as an illustration example simulating the direct irradiation of a biological chromatin fiber. Expected extensions involving several research domains, such as particle physics, chemistry and cellular and molecular biology, within a fully interdisciplinary activity of the Geant4 collaboration are also discussed.
International Journal of Modeling, Simulation, and Scientific Computing. 01/2012; 01(02).
[Show abstract][Hide abstract] ABSTRACT: On behalf of the Geant4 Standard and Low-Energy Electromagnetic Physics Working Groups. The authors are members of the Geant4-DNA collaboration. ABSTRACT Simulation of biological effects of ionizing radiation at the DNA scale requires not only the modeling of direct damages induced on DNA by the incident radiation and by secondary particles but also the modeling of indirect effects of radiolytic products resulting from water radiolysis. They can provoke single and double strand breaks by reacting with DNA. The Geant4 Monte Carlo toolkit is currently being extended for the simulation of biological damages of ionizing radiation at the DNA scale in the framework of the "Geant4-DNA" project. Physics models for the modeling of direct effects are already available in Geant4. In the present paper, an approach for the modeling of radiation chemistry in pure liquid water within Geant4 is presented. In particular, this modeling includes Brownian motion and chemical reactions between molecules following water radiolysis. First results on time-dependent radiochemical yields 1 from 1 picosecond up to 1 microsecond after irradiation are compared to published data and discussed. 1 For a given molecular species, the time-dependent radiochemical yield G is defined as the number of molecules produced for a total absorbed energy of 100 eV in the irradiated medium: , where N(t) is the number of molecules and E is the total energy deposit by the incident ionizing particle into the medium, expressed in eV.
Progress in Nuclear Science and Technology. 07/2011; 2:503-508.
[Show abstract][Hide abstract] ABSTRACT: This paper presents a study of energy deposits induced by ionising particles in liquid water at the molecular scale. Particles track structures were generated using the Geant4-DNA processes of the Geant4 Monte-Carlo toolkit. These processes cover electrons (0.025 eV-1 MeV), protons (1 keV-100 MeV), hydrogen atoms (1 keV-100 MeV) and alpha particles (10 keV-40 MeV) including their different charge states. Electron ranges and lineal energies for protons were calculated in nanometric and micrometric volumes.
Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine 01/2011; 69(1):220-6. · 1.09 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: An overview of the electromagnetic (EM) physics of the Geant4 toolkit is presented. Two sets of EM models are available: the "Standard" initially focused on high energy physics (HEP) while the "Low-energy" was developed for medical, space and other applications. The "Standard" models provide a faster computation but are less accurate for keV energies, the "Low-energy" models are more CPU time consuming. A common interface to EM physics models has been developed allowing a natural combination of ultra-relativistic, relativistic and low-energy models for the same run providing both precision and CPU performance. Due to this migration additional capabilities become available. The new developments include relativistic models for bremsstrahlung and e+e- pair production, models of multiple and single scattering, hadron/ion ionization, microdosimetry for very low energies and also improvements in existing Geant4 models. In parallel, validation suites and benchmarks have been intensively developed.
Progress in NUCLEAR SCIENCE and TECHNOLOGY. 01/2011; 2:898-903.
[Show abstract][Hide abstract] ABSTRACT: The GEANT4 general-purpose Monte Carlo simulation toolkit is able to simulate physical interaction processes of electrons, hydrogen and helium atoms with charge states (H0, H+) and (He0, He+, He2+), respectively, in liquid water, the main component of biological systems, down to the electron volt regime and the submicrometer scale, providing GEANT4 users with the so-called "GEANT4-DNA" physics models suitable for microdosimetry simulation applications. The corresponding software has been recently re-engineered in order to provide GEANT4 users with a coherent and unique approach to the simulation of electromagnetic interactions within the GEANT4 toolkit framework (since GEANT4 version 9.3 beta). This work presents a quantitative comparison of these physics models with a collection of experimental data in water collected from the literature.
An evaluation of the closeness between the total and differential cross section models available in the GEANT4 toolkit for microdosimetry and experimental reference data is performed using a dedicated statistical toolkit that includes the Kolmogorov-Smirnov statistical test. The authors used experimental data acquired in water vapor as direct measurements in the liquid phase are not yet available in the literature. Comparisons with several recommendations are also presented.
The authors have assessed the compatibility of experimental data with GEANT4 microdosimetry models by means of quantitative methods. The results show that microdosimetric measurements in liquid water are necessary to assess quantitatively the validity of the software implementation for the liquid water phase. Nevertheless, a comparison with existing experimental data in water vapor provides a qualitative appreciation of the plausibility of the simulation models. The existing reference data themselves should undergo a critical interpretation and selection, as some of the series exhibit significant deviations from each other.
The GEANT4-DNA physics models available in the GEANT4 toolkit have been compared in this article to available experimental data in the water vapor phase as well as to several published recommendations on the mass stopping power. These models represent a first step in the extension of the GEANT4 Monte Carlo toolkit to the simulation of biological effects of ionizing radiation.
Medical Physics 09/2010; 37(9):4692-708. · 2.91 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: The Geant4-DNA project proposes to develop an open-source simulation software based and fully included in the general-purpose Geant4 Monte Carlo simulation toolkit. The main objective of this software is to simulate biological damages induced by ionising radiation at the cellular and sub-cellular scale. This project was originally initiated by the European Space Agency for the prediction of deleterious effects of radiation that may affect astronauts during future long duration space exploration missions. In this paper, the Geant4-DNA collaboration presents an overview of the whole ongoing project, including its most recent developments already available in the last Geant4 public release (9.3 BETA), as well as an illustration example simulating the direct irradiation of a chromatin fibre. Expected extensions involving several research domains, such as particle physics, chemistry and cellular and molecular biology, within a fully interdiciplinary activity of the Geant4 collaboration are also discussed. Comment: presented by S. Incerti at the ASIA SIMULATION CONFERENCE 2009, October 7-9, 2009, Ritsumeikan University, Shiga, Japan
[Show abstract][Hide abstract] ABSTRACT: The tissue equivalence of solid state silicon detectors in proton radiation fields was determined to improve the radiation protection applications of silicon detectors in aviation and space missions. The study was performed by means of Geant4 simulations. Results are presented showing that a simple c( ~ 0.56) of linear dimensions is adequate to convert experimentally obtained microdosimetric energy deposition spectra in silicon to equivalent microdosimetric energy deposition spectra in water.
IEEE Transactions on Nuclear Science 01/2009; · 1.22 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: New physical processes specific for microdosimetry simulation are under development in the Geant4 Low Energy Electromagnetic package. The first set of models implemented for this purpose cover the interactions of electrons, protons and light ions in liquid water; they address a physics domain relevant to the simulation of radiation effects in biological systems, where water represents an important component. The design developed for effectively handling particle interactions down to a low energy scale and the physics models implemented in the first public release of the software are described.
IEEE Transactions on Nuclear Science 01/2008; · 1.22 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: The accuracy of the Geant4 component for the simulation of atomic relaxation has been evaluated against the experimental measurements of the NIST Standard Reference Data. The validation study concerns X-ray and Auger transition energies. The comparison of the simulated and experimental data with rigorous statistical methods demonstrates the excellent accuracy of the simulation of atomic de-excitation in Geant4.
IEEE Transactions on Nuclear Science 07/2007; · 1.22 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: The Low Energy Electromagnetic package of the Geant4 toolkit incorporates a component for the simulation of atomic relaxation of elements with atomic number between 6 and 100. This process is triggered by the creation of a vacancy in the atomic shell occupancy as a result of an incident particle interaction with an atom of the target material. X-ray fluorescence and Auger electron emission result from the relaxation cascade. The availability of a model handling the atomic relaxation in Geant4 extends the applicability of the simulation toolkit to experimental use cases concerning the investigation of material properties through their characteristic X-ray or Auger emission. It is also relevant to precise simulation applications, like microdosimetry or the design and optimization of detectors based on nanotechnology. The key features of the software development process, the software architecture and design, and the implementation details of the physics model are described.
IEEE Transactions on Nuclear Science 07/2007; · 1.22 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: The Statistical Toolkit is a project for the development of open source software tools for statistical data analysis in experimental particle and nuclear physics. The second development cycle encompassed an extension of the software functionality and new tools to facilitate its usage in experimental environments. The new developments include additional goodness-of-fit tests, new implementations of existing tests to improve their statistical precision or computational performance, a new component to extend the usability of the toolkit with other data analysis systems, and new tools for an easier configuration and build of the system in the user's computing environment. The computational performance of all the algorithms implemented has been studied
IEEE Transactions on Nuclear Science 01/2007; · 1.22 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: A project, named Geant4-DNA, is in progress to extend the Geant4 simulation toolkit to model the effects of radiation with biological systems at cellular and DNA level. The first component implemented in the first development cycle of the project describes the fractional survival of a population of cells irradiated with photons or charged particles. The software system developed provides the user the option to choose among a small set of alternative models for the calculation of mammalian cell survival after irradiation. The flexible design adopted makes the system open to further extension to implement other cell survival models available in literature. The preliminary design of a prototype of the cell survival models implemented and preliminary results in some selected cell lines are described.
[Show abstract][Hide abstract] ABSTRACT: A novel architectural approach to the design of human phantom software models is presented. A detailed design has been developed to enable the adoption of this approach in Geant4-based simulation applications. A few preliminary implementations and application demonstrations are described.
[Show abstract][Hide abstract] ABSTRACT: A comprehensive study has been performed to provide general guidelines for the practical choice of the most suitable goodness-of-fit test in real data analysis. Quantitative comparisons among the goodness-of-fit tests contained in the Statistical Toolkit are presented; the case of samples drawn from smooth theoretical functions is taken into account. This study is the most complete and general approach so far available to characterize the power of goodness-of-fit tests for the comparison of two data distributions. The results provide guidance to the user to identify the most appropriate test for his/her analysis on an objective basis.
[Show abstract][Hide abstract] ABSTRACT: A project is in progress for a systematic, rigorous validation of Geant4 electromagnetic physics. This paper presents the first results concerning the validation of Geant4 bremsstrahlung models against experimental data.
[Show abstract][Hide abstract] ABSTRACT: A comprehensive, rigorous validation of Geant4 electromagnetic and hadronic models pertinent to the simulation of the proton Bragg peak in water is presented. Geant4 simulation results are validated against high precision experimental data taken in the CATANA hadrontherapy facility.
[Show abstract][Hide abstract] ABSTRACT: A set of processes specialized for the simulation of particle interactions with water has been developed in the Geant4 Low Energy Electromagnetic package. The models cover the interactions of electrons, protons and light ions down to the electronvolt energy scale. They address a physics domain relevant to the simulation of radiation effects in biological systems, where water represents an important component. The software design, the physics models implemented and an overview of their tests are described.