[show abstract][hide abstract] ABSTRACT: Fourier-transform infrared transmission spectroscopy has been used for the determination of glucose concentration in whole blood samples from 28 patients. A 4-vector partial least-squares calibration model, using the spectral range 950–1200 cm−1, yielded a standard-error-of-prediction of 0.59 mM for an independent test set. For blood samples from a single patient, we found that the glucose concentration was proportional to the difference between the values of the second derivative spectrum at 1082 cm−1 and 1093 cm−1. This indicates that spectroscopy at these two specific wavenumbers alone could be used to determine the glucose concentration in blood plasma samples from a single patient, with a prediction error of 0.95 mM.
Physics in Medicine and Biology 01/2003; 48(13):2023-2032. · 2.70 Impact Factor
[show abstract][hide abstract] ABSTRACT: Fourier-transform infrared(FTIR) transmission spectroscopy has beenused for the determination of glucoseconcentrations in whole blood samples fromtwenty-eight patients. A four-vectorpartial least squares calibration model,using the spectral range 950–1200 cm-1,yielded a standard error of prediction of0.59 mM for an independent test set. Forblood samples from a single patient, wefound that the glucose concentration wasproportional to the difference between thevalues of the second derivative spectrum at1082 cm-1 and 1093 cm-1, suggestingthat these two specific wavelengths can beused for determining glucose concentrationsin blood.
Journal of Biological Physics 01/2003; 29(2):129-133. · 0.95 Impact Factor