Lei Zhong

Peking University, Beijing, Beijing Shi, China

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Publications (4)8.17 Total impact

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    ABSTRACT: Thirteen compounds were isolated from the anomalous fruits of Gleditsia sinensis on the basis of bioassay-guided fractionation. These saponins together with six analogues or related compounds were tested for their cytotoxicities against six tumor cell lines by the MTT method. The induction of apoptosis in HL-60 cells by these compounds was determined through flow cytometric analysis. Some structure-activity relationships in cytotoxicity and induction of apoptosis were identified. The evaluation of the cytotoxicity and the ability to induce apoptosis revealed that some important structural features are required for activity. A valuable model which enables prediction of their activities was established and may be employed for the drug design of new Gleditsia saponin analogues.
    Planta Medica 10/2004; 70(9):797-802. · 2.35 Impact Factor
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    ABSTRACT: Four biotransformed products of resibufogenin were obtained after 4 days of incubation with cell suspension cultures of Platycodon grandiflorum. On the basis of chemical and spectral data, their structures were elucidated as 3-epi-resibufogenin, marinobufagin, 1β-hydroxy-resibufogenin, and 3-epi-marinobufagin respectively, among which the latter two compounds are new. These compounds were found to exhibit potent cytotoxic activities against Bel-7402, BGC-823, HeLa, and HL-60 human cancer cell lines.
    Letters in Organic Chemistry 03/2004; 1(2):176-178. · 0.67 Impact Factor
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    ABSTRACT: Gleditsioside E, a triterpene saponin isolated from Gleditsia sinensis, showed significant cytotoxicity against Bel-7402, BGC-823, HeLa, HL-60 and MCF-7 cell lines. The results of flow cytometry with annexin V-FITC/PI double staining proved that gleditsioside E mainly induced early apoptosis in HL-60 cells. Gleditsioside E treatment resulted in a prominent increase of the G 2 /M population in HL-60 cells, and an accumulation of the sub-G 1 (hypoploid) peak was observed.
    Planta Medica 07/2003; 69(6):561-3. · 2.35 Impact Factor
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    ABSTRACT: Biotransformation of triptolide 1 by Cunninghamella blakesleana (AS 3.970) was carried out. Seven biotransformation products were obtained and four of them were characterized as new compounds. On the basis of their NMR and mass spectral data, their structures were characterized as 5α-hydroxytriptolide 2, 1β-hydroxytriptolide 3, triptodiolide 4, 16-hydroxytriptolide 5, triptolidenol 6, 19α-hydroxytriptolide 7 and 19β-hydroxytriptolide 8. All the new transformed products (2, 3, 7 and 8) were found to exhibit potent in vitro cytotoxicity against some human tumor cell lines.
    Tetrahedron 06/2003; 59(23):4209-4213. · 2.80 Impact Factor

Publication Stats

19 Citations
8.17 Total Impact Points

Institutions

  • 2003–2004
    • Peking University
      • School of Pharmaceutical Sciences
      Beijing, Beijing Shi, China