Publications (10)24.73 Total impact
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Article: Preoperative factors associated with improvement in visual acuity after globe rupture treatment.
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ABSTRACT: Objective. Globe rupture is a serious condition. Despite advancements in vitrectomy, the postoperative prognosis for visual acuity remains poor in many cases. We conducted multiple regression analysis to identify preoperative factors associated with postoperative visual acuity. Methods. Subjects comprised 24 patients with globe rupture in one eye who had 5 consecutive years of consultation and were followed up for 12 months or longer. Subjects comprised 13 males and 11 females with a mean age of 67.8 ± 17.4 years. Our methods involved performing multiple regression analysis with age, preoperative visual acuity, scope of injury, number of surgeries, hyphema, vitreous hemorrhage, retinal detachment, and subchoroidal hemorrhage as explanatory variables, and postoperative visual acuity as the response variable. Results. Preoperative visual acuity and scope of retinal detachment were explanatory factors found to correlate significantly with postoperative visual acuity after globe rupture. Conclusions. Our results demonstrate that postoperative visual acuity can be predicted to some degree by preoperative visual acuity and the scope of retinal detachment.European journal of ophthalmology 03/2013; · 0.96 Impact Factor -
Article: Genetic Characterization and Susceptibility for Sarcoidosis in Japanese Patients: Risk Factors of BTNL2 Gene Polymorphisms and HLA Class II Alleles.
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ABSTRACT: Purpose. Sarcoidosis is a heterogeneous and multisystem granulomatous disorder. The etiology still is uncertain, but the disease currently is thought to be triggered by various genetic as well as environmental factors. Recently, an association between sarcoidosis and the butyrophilin-like 2 (BTNL2) gene located in close proximity to the HLA-DRB1 gene was reported. The purpose of our study was to verify the relationship between BTNL2 and HLA risk alleles for the susceptibility to sarcoidosis, and to assess whether the BTNL2 association is independent of the HLA risk alleles. Methods. In our study, 11 single nucleotide polymorphisms (rs28362677, rs2076533, rs2076530, rs2076529, rs2294881, rs3763304, rs2076523, rs28362682, rs3806156, rs9268499, rs3763317), including the functional rs2076530 (G > A) of the BTNL2 gene, and HLA-DRB1 and -DQB1 alleles, were genotyped in 237 Japanese patients diagnosed with sarcoidosis and 287 healthy Japanese control subjects. Results. In the patient group, the HLA-DRB1*08:03 (P = 6.15 × 10(-5), odds ratio [OR] = 2.43) and BTNL2 rs2076530_A (P = 6.90 × 10(-6), OR = 1.84) were associated with disease susceptibility. Upon stratification analysis in search for a synergistic effect given the extensive linkage disequilibrium between BTNL2 rs2076530_A and HLA-DRB1*08:03, our results suggested that the risk-bearing allele of these two loci interact negatively. No significant differences were observed in allele frequencies for alleles in patients with ocular and other systemic sarcoidosis. Conclusions. Our studies implicated that the HLA-DRB1 allele is a major contributing genetic factor in the development of sarcoidosis in Japan. However, further studies are needed to verify how HLA or BTNL2 alleles confer the disease phenotype, severity of sarcoidosis.Investigative ophthalmology & visual science 09/2012; 53(11):7109-15. · 3.43 Impact Factor -
Article: Common variants in the COL4A4 gene confer susceptibility to lattice degeneration of the retina.
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ABSTRACT: Lattice degeneration of the retina is a vitreoretinal disorder characterized by a visible fundus lesion predisposing the patient to retinal tears and detachment. The etiology of this degeneration is still uncertain, but it is likely that both genetic and environmental factors play important roles in its development. To identify genetic susceptibility regions for lattice degeneration of the retina, we performed a genome-wide association study (GWAS) using a dense panel of 23,465 microsatellite markers covering the entire human genome. This GWAS in a Japanese cohort (294 patients with lattice degeneration and 294 controls) led to the identification of one microsatellite locus, D2S0276i, in the collagen type IV alpha 4 (COL4A4) gene on chromosome 2q36.3. To validate the significance of this observation, we evaluated the D2S0276i region in the GWAS cohort and in an independent Japanese cohort (280 patients and 314 controls) using D2S0276i and 47 single nucleotide polymorphisms covering the region. The strong associations were observed in D2S0276i and rs7558081 in the COL4A4 gene (Pc = 5.8 × 10(-6), OR = 0.63 and Pc = 1.0 × 10(-5), OR = 0.69 in a total of 574 patients and 608 controls, respectively). Our findings suggest that variants in the COL4A4 gene may contribute to the development of lattice degeneration of the retina.PLoS ONE 01/2012; 7(6):e39300. · 4.09 Impact Factor -
Article: Investigation of association between TLR9 gene polymorphisms and VKH in Japanese patients.
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ABSTRACT: Vogt-Koyanagi-Harada (VKH) disease is an autoimmune disorder affecting melanocytes in the skin, eyes, inner ear, and meninges. The Epstein-Barr virus and cytomegalovirus (CMV) antigen have been hypothesized as possible triggering factors for the disease. Toll-like receptors (TLRs) play an important role in the induction of defense mechanisms of the innate and adaptive immune responses to microbial pathogens. Among TLRs, TLR9 recognizes unmethylated 2'-deoxyribo (cytidine-phosphate guanosine)(CpG) DNA motifs that are frequently present in viruses and plays a central role in the host defense against viral infection. The aim of this study was to investigate whether TLR9 polymorphisms were associated with VKH in a Japanese population. Ninety-four Japanese patients diagnosed with VKH and 125 healthy control subjects were recruited. Five single-nucleotide polymorphisms (SNPs: rs187084, rs5743836, rs352139, rs352140, rs5743845) in the TLR9 gene were genotyped, and allelic and phenotypic diversity was assessed between cases and control subjects. Strong linkage disequilibrium was observed among three SNPs (D' > 0.99), which were located in one haplotype block. Two SNPs (rs5743836 and rs5743845) were monopolymorphic in both cases and controls. No statistically significant association was observed for any of the SNPs between cases and controls. Three SNPs in the TLR9 gene were not significantly associated with susceptibility to VKH.Ocular immunology and inflammation 06/2011; 19(3):202-5. · 0.72 Impact Factor -
Article: Association analysis of Toll-like receptor 7 gene polymorphisms and Behçet's disease in Japanese patients.
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ABSTRACT: Action of Toll-like receptors (TLRs) is deeply associated with defense mechanisms of the innate and adaptive immune responses to microbial pathogens. There have been reports of genetic polymorphisms within the TLR7 gene being closely related to a variety of inflammatory and infectious diseases. Behçet's disease (BD) is an autoinflammatory disease, and the pathogenesis has yet to be fully discovered. We investigated whether polymorphisms of Toll-like receptor 7 (TLR7) are associated with BD by analyzing the frequency of eight single nucleotide polymorphisms (SNPs) within 200 Japanese BD patients and 102 randomized controls. We genotyped nine SNPs in the TLR7 gene and assessed the allele/genotype diversity between cases and controls for all SNPs. In all eight SNPs, statistically significant differences were not observed between cases and controls.Human immunology 03/2011; 72(3):269-72. · 2.55 Impact Factor -
Article: Association of toll-like receptor 2 gene polymorphisms with normal tension glaucoma.
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ABSTRACT: Toll-like receptor 2 (TLR2) is a transmembrane receptor that mediates immune responses to exogenous and endogenous ligands, and interacts with heat-shock proteins, which are reportedly involved in normal tension glaucoma (NTG). We investigated whether TLR2 polymorphisms are associated with NTG. 200 Japanese patients with NTG and 128 healthy Japanese controls were recruited. We genotyped five single-nucleotide polymorphisms (SNPs) in the TLR2 gene and assessed the allele and haplotype diversities between cases and controls for all SNPs. No significant differences in the frequency of TLR2 alleles and haplotypes in the NTG cases were detected, compared with the controls. Our study showed no evidence for an association between TLR2 polymorphisms and NTG. TLR2 polymorphisms may not play an important role in NTG pathogenesis in the Japanese population.Molecular vision 01/2009; 15:2905-10. · 2.20 Impact Factor -
Article: Investigation of the association between Toll-like receptor 2 gene polymorphisms and Behçet's disease in Japanese patients.
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ABSTRACT: Behçet's disease (BD) is a chronic systemic inflammatory disorder characterized by recurrent ocular symptoms, oral and genital ulcers, and skin lesions. The etiology of BD is still uncertain, but genetic and environmental factors likely both play an important role in BD development. In the present study, we investigated whether polymorphisms of Toll-like receptor 2 (TLR2), previously reported to recognize BD candidate antigens, are associated with BD. Two hundred Japanese patients with BD and 128 Japanese healthy controls were recruited. We genotyped five single-nucleotide polymorphisms (SNPs) in the TLR2 gene and assessed the allele/genotype diversity between cases and controls for all SNPs. No significant differences in the frequency of TLR2 alleles, genotypes, and haplotypes in the BD cases were detected compared with the controls. These data indicate that TLR2 polymorphisms do not play an important role in the development of BD.Human Immunology 12/2008; 70(1):41-4. · 2.84 Impact Factor -
Article: [Simulation of airbag impact on eyes after trabeculectomy by finite element analysis method].
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ABSTRACT: A finite element computer model of the human eye after trabeculectomy was used in an experiment of simulated airbag ocular injury. A half-layer-incised scleral flap was created on the limbus and the strength of its adhesion to the outer sclera was set at 30%, 50% and 100%. The simulations were performed at a workstation using the finite element analysis program PAM CRASH (Nihon ESI, Tokyo, Japan), and the airbag was set to hit the surface of the post-trabeculectomy eye at various velocities in two directions, straight to the corneal center or straight to the scleral flap. In the case of airbag impact on the corneal center, the scleral flap was unlikely to rupture except when the airbag impact velocity was 40 m/sec. In the case of airbag impact on the scleral flap, at the lowest impact velocity of 20 m/sec, partial scleral flap rupture was likely to occur only at the lower adhesion strength, and scleral laceration extending to the posterior sclera was observed at impact velocities of over 30 m/sec. These simulation results suggest that current airbags may induce globe rupture in eyes after trabeculectomy treatment.Nippon Ganka Gakkai zasshi 08/2005; 109(7):406-16. -
Article: Multicoated contact lens for bimanual vitreous surgery without endoillumination.
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ABSTRACT: We developed a new multicoated contact lens for use with the bimanual vitrectomy technique. The new lens is made of quartz, and its multicoated surface has properties that decrease light reflection and increase light absorption. The lens is placed on the cornea, and the coaxial light from the operating microscope alone enables surgeons to obtain a clear image of the retinal surface. This new vitrectomy contact lens is very useful for the treatment of eyes with proliferative membranes and allows surgeons to perform vitrectomy by using both hands.Archives of Ophthalmology 04/2004; 122(3):367-8. · 3.71 Impact Factor -
Article: Measured visual acuity of fellow eyes as a prognostic factor in macular hole surgery.
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ABSTRACT: To investigate the effect of the vision of the fellow eye on the visual acuity of eyes after successful macular hole surgery. Prospective consecutive series. A consecutive series of eyes with successful macular hole closure were studied and assigned to one of two groups according to the visual acuity of the fellow eye; a group with visual acuity less than 20/200 and a group with visual acuity of 20/200 or better. Preoperative and postoperative visual acuity in the two groups was measured based on the logarithm of the minimal angle of resolution (LogMAR), and postoperative visual acuity was also determined by using the multiple-letter visual acuity chart, which permitted measurement of visual acuity at an extrafoveal point. Group 1 (<20/200) consisted of 19 eyes and group 2 (>20/200) consisted of 51 eyes. LogMAR visual acuity at 6 months postoperatively was significantly better in group 1 than in group 2 (0.21 vs 0.41, P <.01). The logMAR change 6 months after surgery was significantly greater in group 1 than in group 2 (0.49 vs 0.23, P <.01). There was no significant difference between two groups in logMAR visual acuity at 6 months postoperatively determined with the multiple-letter visual acuity chart (0.20 vs 0.29, P >.05). Visual recovery after successful macular hole surgery is inversely correlated with vision in the fellow eye. Learning to use eccentric fixation may contribute to visual improvement after macular hole surgery.American Journal of Ophthalmology 04/2003; 135(4):493-8. · 4.22 Impact Factor
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2011
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Yokohama City University
Yokohama-shi, Kanagawa-ken, Japan
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