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Publications (2)6.41 Total impact

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    ABSTRACT: This study was designed to explore the presence of a prothrombotic state in the early stages of chronic Chagas' disease by evaluating serum markers of thrombosis and fibrinolysis. Forty-two patients with chronic Chagas' disease (12 men and 30 women, 32.5 6.7 years) were compared with 21 healthy volunteers (10 men and 11 women, 24.2 5.6 years). The markers of thrombotic activation used were fragment 1 + 2, ATM complex, PDF/pdf, D-dimer, and beta-thromboglobulin. Fibrinolysis was evaluated before and after venous occlusion, together with euglobulin lysis time, t-PA, and PAI-1 titers. The markers of thrombotic state were significantly higher in patients with chronic Chagas' disease than in controls: F1 + 2 (p < 0.0001), ATM (p < 0.0001), PDF/pdf (p < 0.05), and D dimer (p < 0.05). There was no significant difference in beta-thromboglobulin (p = 0.06). Euglobulin lysis time, a global fibrinolytic marker, differed significantly (p < 0.0001) between patients with Chagas' disease and healthy volunteers. However, the more specific fibrinolytic markers t-PA and PAI-1 did not differ significantly between the two study groups. Although there were no significant differences in fibrinolytic markers between patients with chronic Chagas' disease and healthy volunteers, the significant increase in thrombosis markers (F1 + 2, ATM complex, PDF/pdf, and D dimer) suggests the presence of a prothrombotic state in the early stages of chronic Chagas' disease.
    Revista Espa de Cardiologia 04/2003; 56(4):377-82. · 3.20 Impact Factor
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    ABSTRACT: Introducción Las complicaciones tromboembólicas son frecuentes en estadios avanzados del período crónico de la enfermedad de Chagas. Objetivo Estudiar, con marcadores de trombosis (trombóticos y fibrinolíticos), si existe un estado protrombótico en los estadios tempranos de la enfermedad de Chagas crónica. Pacientes y método Se estudió a 42 pacientes con enfermedad de Chagas crónica (12 varones y 30 mujeres) con una edad promedio de 32,5 ± 6,7 años, comparándolos con 21 voluntarios sanos (10 varones y 11 mujeres) con una edad promedio de 24,2 ± 5,6 años. Los marcadores de trombosis utilizados fueron: fragmento 1 + 2, complejo ATM, PDF/pdf, dímero D y β-tromboglobulina. Se evaluó la fibrinólisis pre y poscompresión con el tiempo de lisis de las euglobulinas, así como la dosificación de t-PA y PAI-1. Resultados En los marcadores de trombosis se observaron diferencias estadísticamente significativas entre pacientes con enfermedad de Chagas crónica y controles en las variables F1 + 2 (p < 0,0001), ATM (p < 0,0001), PDF/pdf (p < 0,05) y dímero D (p < 0,05). La β-tromboglobulina no alcanzó significación estadística (p = 0,06). En cuanto a las variables fibrinolíticas, la diferencia fue estadísticamente significativa en el tiempo de lisis de las euglobulinas (p < 0,0001), tanto en condiciones basales como después de provocar estrés con oclusión venosa. En cambio, los valores de t-PA y PAI-1 en condiciones similares no pusieron de manifiesto diferencias estadísticamente significativas entre los grupos estudiados. Conclusiones En los resultados obtenidos se observa que no existe alteración de la fibrinólisis, pero el incremento significativo de los marcadores de trombosis (F1 + 2, complejo ATM, PDF/pdf y dímero D) sugeriría la existencia de un estado protrombótico en estadios tempranos de la enfermedad de Chagas crónica. Background Thromboembolic complications are frequent in advanced Chagas’ disease. Objective This study was designed to explore the presence of a prothrombotic state in the early stages of chronic Chagas’ disease by evaluating serum markers of thrombosis and fibrinolysis. Patients and method Forty-two patients with chronic Chagas’ disease (12 men and 30 women, 32.5 ± 6.7 years) were compared with 21 healthy volunteers (10 men and 11 women, 24.2 ± 5.6 years). The markers of thrombotic activation used were fragment 1 + 2, ATM complex, PDF/pdf, D-dimer, and β-thromboglobulin. Fibrinolysis was evaluated before and after venous occlusion, together with euglobulin lysis time, t-PA, and PAI-1 titers. Results The markers of thrombotic state were significantly higher in patients with chronic Chagas’ disease than in controls: F1 + 2 (p < 0.0001), ATM (p < 0.0001), PDF/pdf (p < 0.05), and D dimer (p < 0.05). There was no significant difference in β-thromboglobulin (p = 0.06). Euglobulin lysis time, a global fibrinolytic marker, differed significantly (p < 0.0001) between patients with Chagas’ disease and healthy volunteers. However, the more specific fibrinolytic markers t-PA and PAI-1 did not differ significantly between the two study groups. Conclusions Although there were no significant differences in fibrinolytic markers between patients with chronic Chagas’ disease and healthy volunteers, the significant increase in thrombosis markers (F1 + 2, ATM complex, PDF/pdf, and D dimer) suggests the presence of a prothrombotic state in the early stages of chronic Chagas’ disease.
    Revista Espa de Cardiologia 01/2003; 56(4):377-382. · 3.20 Impact Factor