J Boschert

Publications (2)2.91 Total impact

• Article: Bilateral meningiomatous lesions of the spinal accessory nerves.

  C Thomé, R Grobholz, J Boschert, P Schmiedek
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  ABSTRACT: Meningiomas arising from cranial nerves with no dural attachment are exceedingly rare. The authors present a patient with bilateral meningiomatous lesions originating symmetrically from both spinal accessory nerves. A 61-year old woman presented with a one-year history of spinal ataxia and minimal left-sided motor impairment. Magnetic resonance imaging demonstrated two extrinsic lesions dorsolaterally of the medulla. Surgical exposure via a midline suboccipital approach with C1 laminectomy revealed the lesions arising from the spinal accessory nerves and in direct contact with the vertebral arteries. Histological investigation showed hypocellular fibrous lesions with proliferating meningothelial cells, psammoma bodies and immunoreactivity for vimentin, S-100 protein and epithelial membrane antigen. To the authors' knowledge this is the first report of intradural tumours of the spinal accessory nerves not derived from Schwann cells and the first report of bilateral intracranial meningiomatous lesions without dural attachment.
  Acta Neurochirurgica 05/2003; 145(4):309-13; discussion 313. · 1.52 Impact Factor
• Article: Isochromosome 1q as an early genetic event in a child with intracranial ependymoma characterized by molecular cytogenetics.

  M Granzow, S Popp, S Weber, B Schoell, H Holtgreve-Grez, L Senf, D Hager, J Boschert, W Scheurlen, A Jauch
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  ABSTRACT: Data concerning cytogenetic features of childhood ependymoma are rare. In this article, a gain of 1q was identified as the sole alteration in a primary childhood infratentorial ependymoma by comparative genomic hybridization (CGH). A recurrence of this brain tumor was studied using multiplex-fluorescence in situ hybridization (M-FISH) in addition to CGH and G-banding analysis. In accordance with the primary tumor, a gain of 1q corresponding to an isochromosome 1q was observed indicating an early event in the tumor development. Furthermore, M-FISH classified several other rearranged chromosomes including 6q and 17p that have previously been found to be involved in the development and progression of childhood ependymoma.
  Cancer Genetics and Cytogenetics 11/2001; 130(1):79-83. · 1.39 Impact Factor