J P Louboutin-Croc

International Centre of Medical Research of Franceville, Franceville, Haut-Ogooué, Gabon

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Publications (5)1.31 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: In the framework of the Human Immunodeficiency Virus (HIV) surveillance, seroprevalence and behavioural survey was conducted in 2002 in Dirkou, a place of concentration of female sex workers (FSW) in Niger The global HIV seroprevalence found was 50% (CI at 95%: 40.6-59.36%). The behavioural survey revealed that 98% of FSW had heard about HIV whereas 78.7% know at least one HIV transmission way and 76.9% know at least one HIV prevention means. Only 33.3% declared using condom, what show that sensitisation efforts are needed to induce a behaviour change in FSW and their clients.
    Bulletin de la Société de pathologie exotique 04/2006; 99(1):49-51.
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    ABSTRACT: Undertaking a HIV seroepidemiological survey in Sahel is logistically problematic, since countries like Niger or Mali are very large with scattered populations and harsh climatic conditions. Therefore, the replacement of serum samples by whole blood dried on filter papers has been studied for HIV-antibody testing with commercial kits that are commonly used. In Niger, two tests ELISA (Genscreen HIV1/2 version 2, Vironostika HIV Uni-Form II Ag/Ab) and two rapid tests (Determine HIV1/2 et Immunocomb II HIV1&2 Bispot) were used to compare the dried blood spots and serum samples from 43 control individuals. Both ELISAs gave an excellent correlation (r = 0.99 et r = 0.98) between the dried blood spots and serum absorbance values. Using the rapid tests, the HIV status was found 100% concordant with dried blood spots and serum samples. An algorithm using three out of the four mentioned tests was defined then validated on the dried blood spots of 163 control individuals (100% concordant). In conclusion, dried blood spots may accurately and profitably replace serum samples for the serodiagnosis of HIV infection and for mass serosurveys in Sahel.
    Bulletin de la Société de pathologie exotique 01/2006; 98(5):343-6.
  • Source
    Journal de la société de Biologie Clinique. 01/2004; 8:21-24.
  • Annals of Tropical Medicine and Parasitology 04/2003; 97(2):209-12. · 1.31 Impact Factor
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    ABSTRACT: During the studies on malaria chemoresistance, we noted great variations in parasite density of Plasmodium falciparum between screening in the morning and final selection in the afternoon, in asymptomatic people. To better understand this phenomenon, we conducted a study in october 1987 on primary school children in a village near the city of Bobo-Dioulasso, at the peak malaria prevalence. We performed 3 blood-smears at 8 a.m., 2 p.m. and 8 p.m., on Day 0 and Day 4, to an initial number of 86 children, aged from 6 to 9 years. By the end of the study 44 children remained who fulfilled the inclusion criteria Among them 35 showed a parasitaemia on Day 0 and 9 remained negative. On Day 4, 28 were positive and 16 remained negative. Of the 35 children positive at entry to the study 16 remained continuously positive, the others were negative on at least one occasion. Of the 28 children positive on Day 4, 14 remained continuously positive. For the 16 people with a parasitaemia continuously positive on Day 0.7 (43.7 p. cent) became spontaneously negative on Day 4. But considering the small size of our sample, the analysis of the nycthemeral variation and of the variation between the two days did not show a significant difference. Further studies involving a greater number of blood-smears during a longer period and concerning more people, should be conducted. The possibility of spontaneous negativation of the parasitaemia without drug absorption shows that there are some cases of false malaria chemosensitivity that are declared when the in vivo tests are not coupled with in vitro tests.
    Médecine tropicale: revue du Corps de santé colonial 52(3):313-5.

Publication Stats

11 Citations
1.31 Total Impact Points

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Institutions

  • 2006
    • International Centre of Medical Research of Franceville
      Franceville, Haut-Ogooué, Gabon