J Raymond

Publications (1)1.52 Total impact

• Article: Identification of a mouse orthologue of the CED-6 gene of Caenorhabditis elegans.

  H Banerjee, Z Hawkins, T Johnson, S Eley, A Alikhan, M Mcdaniel, I Singh, J Raymond
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  ABSTRACT: The rapid engulfment of apoptotic cells is a specialized innate immune response used by organisms to remove apoptotic cells. In mammals, several receptors that recognize apoptotic cells have been identified. Previous analysis of the engulfment gene ced-6 in Caenorhabditis elegans (C. elegans) has suggested that CED-6 is an adapter protein that participates in signal transduction pathway that mediates the specific recognition and engulfment of apoptotic cells. Here, we describe our isolation and partial characterization of a mouse cDNA, which is like an orthologue of C. elegans CED-6. PCR screening of mouse cDNA pool with primers designed from the C. elegans CED-6 cDNA sequence resulted in about 300 bp PCR product which was partially sequenced and then screened to a mouse full-length cDNA library. Thus in this study we report the identification of a novel C. elegans CED-6-like orthologue in mouse, which has probable apoptotic like function.
  Plasmid 02/2003; 49(1):30-3. · 1.52 Impact Factor