Publications (2)7.64 Total impact
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Article: Modulation of J774.1 macrophage L-arginine metabolism by intracellular Mycobacterium bovis BCG.
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ABSTRACT: Using a Mycobacterium bovis BCG mutant (AS1) lacking a Bacillus subtilis L-arginine transporter homolog, we demonstrate here that the interaction between intracellular mycobacteria and the macrophage with respect to L-arginine transport and metabolism is quite complex. Intracellular AS1 stimulates macrophage L-arginine transport and accumulates 2.5-fold more (3)H label derived from L-arginine than does the wild type. These studies suggest that the accumulation of (3)H label reflects the acquisition of metabolites of L-arginine produced by the macrophage.Infection and Immunity 03/2003; 71(2):1011-5. · 4.16 Impact Factor -
Article: Nitric oxide regulation of L-arginine uptake in murine and human macrophages.
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ABSTRACT: L-arginine uptake systems in macrophages play a role in regulating nitric oxide synthesis via the inducible L-arginine nitric oxide pathway. This paper describes the association of L-arginine transport with nitric oxide production in human peripheral blood monocyte-derived macrophages and in peritoneal macrophages from control and inducible nitric oxide synthase knock out C57BL6 mice. Experiments performed with human macrophages suggested that little or no nitric oxide was produced in human macrophages in vitro and that human macrophages exhibit a different arginine transport-specific response to stimuli compared with rodent macrophages. We conclude that increased L-arginine transport in both human and murine macrophages is dependent on the requirement for intracellular nitric oxide.Tuberculosis 02/2003; 83(5):311-8. · 3.47 Impact Factor
Top Journals
- Infection and Immunity (1)
- Tuberculosis (1)
Institutions
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2003
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Ramapo College
- School of Theoretical and Applied Science (TAS)
New York City, NY, USA
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