Kiyoshi Mizuno

Publications (2)5.35 Total impact

• Article: Cardiovascular tolerance and autonomic nervous responses in unsedated upper gastrointestinal small-caliber endoscopy: a comparison between transnasal and peroral procedures with newly developed mouthpiece.

  Hiromi Kataoka, Junichiro Hayano, Takashi Mizushima, Mamoru Tanaka, Eiji Kubota, Takaya Shimura, Tsutomu Mizoshita, Satoshi Tanida, Takeshi Kamiya, Shunsuke Nojiri, Seiji Mukai, Kiyoshi Mizuno, Takashi Joh
  [show abstract] [hide abstract]
  ABSTRACT: Transnasal esophagogastroduodenoscopy (EGD) with small-caliber endoscopy appears to be less stressful to the cardiovascular system and has good patient tolerance. ENDO LEADER, a newly developed mouthpiece for peroral EGD with small-caliber endoscopy, is expected to reduce patient stress. We compared the patient acceptance, cardiovascular tolerance and autonomic nervous responses between transnasal EGD and peroral EGD with ENDO LEADER. A total of 130 patients (transnasal group, 77; peroral group, 53) were enrolled. Pulse rate (P), blood pressure (BP), and peripheral blood oxygen saturation (SpO(2) ) were monitored. Acceptance of EGD was also assessed. Autonomic nervous responses were evaluated through analysis of heart rate variability using amplitude of the high-frequency component (HF) and low-frequency-to-high-frequency power ratio (LF/HF) as indices of cardiac vagal activity and sympathetic activity, respectively. Analysis of patient acceptance showed no differences between the two groups, except with regard to nasal pain. Increases in BP and P between before and during EGD examination were significantly higher in the peroral group. Although throat pain and overall tolerance scores were significantly correlated with ΔBP and ΔP, no correlations with nasal pain score were noted. Heart rate variability analysis revealed that heart rate increased significantly in the peroral group, but there were no differences in ΔHF or ΔLF/HF between the two groups. Patient acceptance was not significantly different between the transnasal and peroral with ENDO LEADER groups; however, transnasal EGD appears to be less stressful to the sympathetic nervous system, leading to smaller elevations in BP, P and heart rate.
  Digestive Endoscopy 01/2011; 23(1):78-85. · 1.19 Impact Factor
• Article: Adenosquamous carcinoma of the jejunum.

  Tsuneya Wada, Kiyoshi Mizuno, Kazuyuki Itoh, Takashi Monoe, Hakuji Ando, Yutaka Kondo, Hiroki Takada, Kanto Ogawa, Michio Kanai, Takashi Joh, Makoto Itoh
  [show abstract] [hide abstract]
  ABSTRACT: Primary adenosquamous carcinomas of the intestine are rare, particularly in the small intestine. One case, in the jejunum of an adult female, is described here. The patient was a 70-year-old Japanese woman presenting with upper abdominal pain. Computed tomography of the abdomen showed a mass in the small intestine, measuring 86 x 44 mm, and a double-contrast barium study revealed a filling defect in the upper jejunum. The patient was diagnosed as suffering from upper small-intestinal cancer, and surgical excision was performed. Histological examination, including immunohistochemistry and electron microscopy, revealed the tumor to have both malignant glandular and squamous components. A review of the literature regarding this type of lesion is presented.
  Journal of Gastroenterology 02/2003; 38(8):786-90. · 4.16 Impact Factor