Chun-Yan Hong

University of Science and Technology of China, Luchow, Anhui Sheng, China

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Publications (51)194.75 Total impact

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    ABSTRACT: Generally, it is very difficult to control the size of large compound vesicles. Here, we introduce a novel method for the preparation of biodegradable large compound vesicles with controlled size and narrow size distribution by using aqueous nanodroplets as templates.
    Chemical Communications 07/2014; · 6.38 Impact Factor
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    ABSTRACT: In this study, we have prepared a self-cross-linking PEG-based branched polymer, which easily forms a bioreducible nanoshell around polyplexes of cationic polymer and DNA, simply via heating the polyplex dispersions in the presence of the self-cross-linking branched polymer. This nanoshell can prevent the polyplex from dissociation and aggregation in physiological fluids without inhibiting the electrostatic interactions between the polymer and DNA. Furthermore, glutathione (GSH) can act as a stimulus to open the nanoshell after it has entered the cell. The polyplexes coated with the bioreducible nanoshell show an obvious enhancement in gene transfection in vivo compared with bare polyplexes.
    Biomacromolecules 06/2014; · 5.37 Impact Factor
  • Wen-Jian Zhang, Chun-Yan Hong, Cai-Yuan Pan
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    ABSTRACT: Silica nanotubes with controlled diameters and lengths were fabricated by a template-directed method. Nanowires composed of poly(2-dimethylaminoethyl methacrylate)-block-polystyrene (PDMAEMA–PS), which were fabricated by RAFT dispersion polymerization of styrene in methanol using PDMAEMA as a macro-RAFT agent, were used as sacrificial templates. The diameter of the polymeric nanowires can be adjusted by changing the degree of polymerization (DP) of the hydrophilic PDMAEMA block. As the chain length of the hydrophilic PDMAEMA block increases, the DP of the PS block for formation of the nanowires increases, leading to the diameter increase of the corresponding nanowires. Moreover, the polymeric nanowires with controlled lengths and diameters of the core and the shell can be fabricated on a large scale through polymerization-induced self-assembly and reorganization, conveniently. The weak polyelectrolyte, PDMAEMA shell, is an ideal nanoreactor for deposition of silica to form hybrid nanowires. Silica nanotubes were prepared by calcination of the hybrid nanowires.
    J. Mater. Chem. A. 05/2014; 2(21).
  • Wen-Jian Zhang, Chun-Yan Hong, Cai-Yuan Pan
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    ABSTRACT: Different from concentric vesicles without spacing between the walls, the concentric vesicles with uniform spacing between the walls were rarely fabricated. We successfully fabricate the spaced concentric vesicles (SCVs) via RAFT dispersion polymerization, and continuous propagation of the residual polymer chains inside the large vesicles induces self-assembling to form SCVs. Concentration of the residual polymer chains in the solution of the nascent-formed vesicles is the determining factor for formation of SCVs, and continuous propagation of less or too more residual polymer chains will not form SCVs but form other morphologies. Generally, the concentration of the residual polymer chains after formation of vesicles is too low to self-assemble, so formation of SCVs is impossible. By adjusting the ratio of St/methanol or macro-RAFT agent P4VP-b-PS/P4VP, the concentration of residual polymer chains can be controlled, and further control of the morphologies is achieved. Formation of the inner vesicles by self-assembling inside the large vesicles requires high molecular weight of the polymer chains due to their very low concentration. The polymers of inner vesicles possess very high molecular weight (×106 g/mol) in comparison with the polymer of outmost vesicles (×105 g/mol). Polymerization kinetic study reveals very high increasing rate of the molecular weight inside the vesicles probably owing to long duration of the chain radicals, and the polymerization rate (Rp) inside the vesicles is faster than the Rp in the outmost vesicles, but both rates are in the same order.
    Macromolecules 02/2014; 47(5):1664–1671. · 5.93 Impact Factor
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    ABSTRACT: A new and easy method of stimuli-triggered growth and removal of a bioreducible nanoshell on nanoparticles is reported. The results show that pH or temperature could induce the aggregation of disulfide-contained branched polymers at the surface of nanoparticles; subsequently, the aggregated polymers could undergo intermolecular disulfide exchange to cross-link the aggregated polymers, forming a bioreducible polymer shell around nanoparticles. When these nanoparticles with a polymer shell are treated with glutathione (GSH) or d,l-dithiothreitol (DTT), the polymer shell could be easily removed from the nanoparticles. The potential application of this method is demonstrated by easily growing and removing a bioreducible shell from liposomes, and improvement of in vivo gene transfection activity of liposomes with a bioreducible PEG shell.
    Macromolecular Rapid Communications 02/2014; · 4.93 Impact Factor
  • Di Wang, Zhi-Qiang Yu, Chun-Yan Hong, Ye-Zi You
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    ABSTRACT: Hyperbranched poly(amido amine)s (HPAA) show weak photoluminescence, however, they have shown strong emission after short polyethylene glycol (PEG) chains have been linked onto HPAA macromolecule via Michael addition reaction. These PEGylated hyperbranched poly(amido amine)s show low cytotoxicity and potential application in cell imaging.
    European Polymer Journal 12/2013; 49(12):4189–4194. · 3.24 Impact Factor
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    ABSTRACT: A versatile one-pot strategy for the preparation of reversibly cross-linked polymer-coated mesoporous silica nanoparticles (MSNs) via surface reversible addition-fragmentation chain transfer (RAFT) polymerization is presented for the first time in this paper. The less reactive monomer oligo(ethylene glycol) acrylate (OEGA) and the more reactive cross-linker N,N'-cystaminebismethacrylamide (CBMA) are chosen to be copolymerized on the external surfaces of RAFT agent-functionalized MSNs to form the cross-linked polymer shells. Owing to the reversible cleavage and restoration of disulfide bonds via reduction/oxidation reactions, the polymer shells can control the on/off switching of the nanopores and regulate the drug loading and release. The redox-responsive release of doxorubicin (DOX) from this drug carrier is realized. The protein adsorption, in vitro cytotoxicity assays, and endocytosis studies demonstrate that this biocompatible vehicle is a potential candidate for delivering drugs. It is expected that this versatile grafting strategy may help fabricate satisfying MSN-based drug delivery systems for clinical application.
    Macromolecular Rapid Communications 07/2013; · 4.93 Impact Factor
  • Ying Wang, Chun-Yan Hong, Cai-Yuan Pan
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    ABSTRACT: Redox-responsive amphiphilic diblock copolymers, poly(6-O-methacryloyl-d-galactopyranose-co-2-(N,N-dimethylaminoethyl) methacrylate)-b-poly(pyridyl disulfide ethyl methylacrylate) (P(MAGP-co-DMAEMA)-b-PPDSMA) were obtained by deprotection of poly((6-O-methacryloyl-1,2:3,4-di-O-isopropylidene-d-galactopyranose)-co-DMAEMA)-b-PPDSMA [P(MAlpGP-co-DMAEMA)-b-PPDSMA], which were prepared via reversible addition-fragmentation chain transfer (RAFT) polymerization of PDSMA using P(MAlpGP-co-DMAEMA) as macro-RAFT agent. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) studies showed that diblock copolymers P(MAGP-co-DMAEMA)-b-PPDSMA can self-assemble into micelles. Doxorubicin (DOX) could be encapsulated by P(MAGP-co-DMAEMA)-b-PPDSMA upon micellization and released upon adding glutathione (GSH) into the micelle solution. The galactose functional groups in the PMAGP block had specific interaction with HepG2 cells, and P(MAGP-co-DMAEMA)-b-PPDSMA can act as gene delivery vehicle. So, this kind of polymer has potential applications in hepatoma-targeting drug and gene delivery and biodetection.
    Biomacromolecules 04/2013; · 5.37 Impact Factor
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    ABSTRACT: A novel and versatile method for one-pot and in situ generation of bioreducible and acid labile nanogels/microgels simply via adding water into the polymerization system is reported. The produced polymers in the polymerization system become temperature-sensitive and less soluble after adding water, and hence they collapse together, forming nanoparticles. Subsequently, the disulfides inside the nanoparticle undergo intermolecular disulfide exchange to crosslink the nanoparticle into a bioreducible and acid labile nanogel/microgel. The size of the nanogel/microgel can be easily controlled by the polymerization time and the amount of water added. The formed nanogel/microgel is redox and pH responsive, and biocompatible.
    Polym. Chem. 02/2013; 4(5):1694-1699.
  • Jiao-Tong Sun, Chun-Yan Hong, Cai-Yuan Pan
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    ABSTRACT: Differently from bulk, solution, suspension, emulsion, and miniemulsion polymerizations, the controlled radical dispersion polymerization (CRDP) demonstrates self-assembly of the block copolymers formed in the homogeneous system, forming various kinds of micelles or vesicles. Thus, this technology can prepare both the block copolymers and the polymeric aggregates directly. Among CRDP, the reversible addition-fragmentation chain transfer (RAFT) dispersion polymerization has been studied in relative detail and has been successfully developed to prepare a diverse range of assemblies. Several typical systems for RAFT dispersion polymerization are presented in detail and the factors influencing the polymerization and the in situ self-assembly are also highlighted in this minireview.
    Polym. Chem. 01/2013; 4(4):873-881.
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    ABSTRACT: In nature, a sapling can grow into a big tree under irradiation of sunlight. In chemistry, a similar concept that a small molecule only exposing to sunlight grows into a hyperbranched macromolecule has not been realized by now. The achievement of the concept will be fascinating and valuable for polymer synthesis wherein sunlight is inexpensive, abundant, renewable, and nonpolluting. Herein, we report a new strategy in which small monomers can directly grow into big hyperbranched macromolecule under irradiation of sunlight without any catalyst.
    Scientific Reports 01/2013; 3:2841. · 5.08 Impact Factor
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    ABSTRACT: Conventional polymers of nonfluorescent monomers show strong fluorescence without incorporating any fluorescent agent. The intensity of photoluminescence of these polymers is similar to that emitted by conventional fluorophore-containing polymers. This finding offers a simple yet versatile platform to prepare polymers of strong fluorescence without using fluorescent molecules.
    Advanced Materials 08/2012; · 14.83 Impact Factor
  • Jiao-Tong Sun, Chun-Yan Hong, Cai-Yuan Pan
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    ABSTRACT: The self-assembly of block copolymers attracts wide interest due to many potential applications of the polymeric aggregates. Great effort has been made to realize the convenient fabrication of abundant polymeric materials with well-defined nanostructures. This review introduces the development of the in situ preparation of block copolymer aggregates by heterogeneous polymerization. Great emphasis is put on discussing the formation mechanism of aggregates with different morphologies. Some important factors that influence the morphologies are illustrated when different polymerization methods are employed. By demonstrating some recent advances and existing problems in this area, more attention and effort should be paid to this field to facilitate its further progress.
    Soft Matter 07/2012; 8(30):7753-7767. · 4.15 Impact Factor
  • Ying Wang, Chun-Yan Hong, Cai-Yuan Pan
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    ABSTRACT: Photo- and pH-responsive amphiphilic hyperbranched star copolymers, poly(6-O-methacryloyl-1,2;3,4-di-O-isopropylidene-d-galactopyranose)[poly(2-(N,N-dimethylaminoethyl) methacrylate)-co-poly(1'-(2-methacryloxyethyl)-3',3'-dimethyl-6-nitro-spiro(2H-1-benzo-pyran-2,2'-indoline))](n)s [HPMAlpGP(PDMAEMA-co-PSPMA)(n)], were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization of the DMAEMA and the SPMA using hyperbranched PMAlpGP as a macro RAFT agent. In aqueous solution, the copolymers self-assembled to form core-shell micelles with HPMAlpGP core and PDMAEMA-co-PSPMA shell. The hydrophobic fluorescent dye nitrobenzoxadiazolyl derivative (NBD) was loaded into the spiropyran-containing micelles. The obtained micelles not only have the photochromic properties, but also modulate the fluorescence of NBD through fluorescence resonance energy transfer (FRET), which was also observed in living cells. Slight fluorescence intensity decrease of the spiropyran in merocyanine (ME) form was observed after five UV-visible light irradiation cycles. The cytotoxicity of the HPMAlpGP(PDMAEMA-co-PSPMA)(n) micelles was lower than that of 25k PEI. All the results revealed that these photoresponsive nanoparticles are a good candidate for cell imaging and may find broad applications in biological areas such as biological diagnosis, imaging, and detection.
    Biomacromolecules 07/2012; 13(8):2585-93. · 5.37 Impact Factor
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    ABSTRACT: A facile temperature induced self-assembly and self-crosslinking method has been developed for preparing bioreducible nanogels/microgels without need of any stabilizer, catalyst or additional crosslinking agent. The size of formed nanogels/microgels can be easily tuned via the polymer concentration.
    Chemical Communications 04/2012; 48(45):5623-5. · 6.38 Impact Factor
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    ABSTRACT: A novel nanocontainer, which could regulate the release of payloads, has been successfully fabricated by attaching zwitterionic sulfobetaine copolymer onto the mesoporous silica nanoparticles (MSNs). RAFT polymerization is employed to prepare the hybrid poly(2-(dimethylamino)ethyl methacrylate)-coated MSNs (MSN-PDMAEMA). Subsequently, the tertiary amine groups in PDMAEMA are quaternized with 1,3-propanesultone to get poly(DMAEMA-co-3-dimethyl(methacryloyloxyethyl)ammonium propanesulfonate)-coated MSNs [MSN-Poly(DMAEMA-co-DMAPS)]. The zwitterionic PDMAPS component endows the nanocarrier with biocompatibility, and the PDMAEMA component makes the copolymer shell temperature-responsive. Controlled release of loaded rhodamine B has been achieved in the saline solutions.
    Macromolecular Rapid Communications 04/2012; 33(9):811-8. · 4.93 Impact Factor
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    ABSTRACT: Selectivity for the Diels-Alder cycloaddition reaction of the electron-rich diene with single-walled carbon nanotubes was first investigated. This chemistry is a complete departure from the curvature-dependent reactivity based on the carbon pyramidalization angle.
    Chemical Communications 09/2011; 47(38):10704-6. · 6.38 Impact Factor
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    ABSTRACT: A direct access to photochromic polymeric vesicles was demonstrated via polymerization-induced self-assembly and reorganization (PISR). The resulting vesicles displayed interesting photochromic behaviors different from that of their free polymer chains in DMF, and the vesicles exhibited stronger fluorescence and excellent photostability due to confinement of conformational flexibility of the polymer chains in aggregates.
    Macromolecular Rapid Communications 06/2011; 32(15):1174-9. · 4.93 Impact Factor
  • Jiao-Tong Sun, Chun-Yan Hong, Cai-Yuan Pan
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    ABSTRACT: Carbon nanotubes (CNTs) are of increasing interest to scientists because of their unique electronic, chemical and mechanical properties. However, the poor solubility in solvents limits the manipulation of CNTs and hampers their applications in many promising fields. Surface modification of CNTs with polymers is an efficient method to solve this problem. In comparison with linear polymers, dendrimers and hyperbranched polymers are highly branched macromolecules with three-dimensional architecture, and they have good solubility, low melt viscosity, and extremely high density of functional groups at the surface. By surface modification with dendrimers or hyperbranched polymers, the solubility of CNTs could be improved greatly. Moreover, the resultant composites can be endowed with novel properties by further functionalization, which enlarges the applications of CNTs. This review makes emphasis on discussing the methods for functionalization of CNTs with dendrimers or hyperbranched polymers, meanwhile, the unique properties and potential applications of the resultant composites are also summarized in an attempt to facilitate the progress in this interesting area.
    Polym. Chem. 04/2011; 2(5).
  • Jun-Jie Yan, Chun-Yan Hong, Ye-Zi You
    Macromolecules 03/2011; 44(6):1247-1251. · 5.93 Impact Factor