Chun-Yan Hong

Chinese Academy of Sciences, Peping, Beijing, China

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Publications (60)309.57 Total impact

  • Xiang Chen · Jiao-Tong Sun · Cai-Yuan Pan · Chun-Yan Hong
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    ABSTRACT: Thermo-responsive Au-polymer hybrid microgels were prepared by a facile temperature-induced co-aggregation and self-crosslinking (TICASC) method, needing no complex operations such as preforming of microgels or prior modification of GNPs. The hybrid microgels were utilized as catalysts for the reduction of 4-nitrophenol, which exhibited good activity and recyclability.
    06/2015; DOI:10.1039/C5PY00774G
  • Ze Zhang · Ye-Zi You · De-Cheng Wu · Chun-Yan Hong
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    ABSTRACT: Multicomponent reactions have recently attracted a great deal of attention as they are considered as a powerful tool for constructing sequence-controlled polymers. Although new examples are constantly flourishing in the literature, the process that allows two or more consecutive multicomponent-reactions to react in a single operation for the syntheses of sequence-controlled polymers has not been developed until now. Here, we propose a new strategy combining multicomponent reaction of amine, thiol, and alkene conjugating and multicomponent polymerization of diyne, azide, and diamine coupling in one-pot for the synthesis of sequence-controlled polymer.
    Macromolecules 05/2015; 48(11):150520112816008. DOI:10.1021/acs.macromol.5b00463 · 5.93 Impact Factor
  • Source
    Cai-Yuan Pan · Liang Qiu · Chun-Yan Hong
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    ABSTRACT: Redox-and pH-sensitive branched star polymers (BSPs), BP(DMAEMA-co-MAEBA-co-DTDMA)(PMAIGP)ns, have been successively prepared by two steps of reversible addition-fragmentation chain transfer (RAFT) polymerization. The first step is RAFT polymerization of 2-(N,N-dimethylaminoethyl)methacrylate (DMAEMA) and p-(methacryloxyethoxy) benzaldehyde (MAEBA) in the presence of divinyl monomer, 2,2'-dithiodiethoxyl dimethacrylate (DTDMA). The resultant branched polymers were used as a macro-RAFT agent in the subsequent RAFT polymerization. After hydrolysis of the BSPs to form BP(DMAEMA-co-MAEBA-co-DTDMA)(PMAGP)ns (BSP-H), the anticancer drug doxorubicin (DOX) was covalently linked to branched polymer chains by reaction of primary amine of DOX and aldehyde groups in the polymer chains. Their compositions, structures, molecular weights, and molecular weight distributions were respectively characterized by nuclear magnetic resonance spectra and gel permeation chromatography measurements. The DOX-loaded micelles were fabricated by self-assembly of DOX-containing BSPs in water, which were characterized by transmission electron microscopy and dynamic light scattering. Aromatic imine linkage is stable in neutral water, but is acid-labile; controlled release of DOX from the BSP-H-DOX micelles was realized at pH values of 5 and 6, and at higher acidic solution, fast release of DOX was observed. In vitro cytotoxicity experiment results revealed low cytotoxicity of the BSPs and release of DOX from micelles in HepG2 and HeLa cells. Confocal laser fluorescence microscopy observations showed that DOX-loaded micelles have specific interaction with HepG2 cells. Thus, this type of BSP micelle is an efficient drug delivery system.
    International Journal of Nanomedicine 05/2015; 10:3623. DOI:10.2147/IJN.S78355 · 4.38 Impact Factor
  • Long-Hai Wang · Zi-Dan Zhang · Chun-Yan Hong · Xue-Hao He · Wei You · Ye-Zi You
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    ABSTRACT: Anion-dipole interactions can make homopolymers self-assemble like an amphiphilic block copolymer. Generally, common homopolymers cannot self-assemble into multiple nanostructures. Here, it is reported that anion-dipole interactions can enable a number of homopolymers to achieve a variety of self-assembly behaviors in aqueous solution. Such interactions and self-assembly features have been exclusively reserved for amphiphilic (block) polymers until now. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Advanced Materials 04/2015; 27(20). DOI:10.1002/adma.201405579 · 17.49 Impact Factor
  • Jiemei Zhou · Wen-Jian Zhang · Chun-Yan Hong · Cai-Yuan Pan
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    ABSTRACT: A novel nanocontainer, which has silica nanotube core and pH-sensitive polymer shell attaching on the exterior surface of silica nanotube, is presented in this paper. Polymer nanorods, which are conveniently fabricated though polymerization-induced self-assembly and re-organization (PISR) method, are used as templates for the deposition of silica to fabricate hybrid nanorods. Calcination of as-synthesized silica hybrid nanorods leads to hollow silica nanotubes (SNTs). SNTs are functionalized with reversible addition-fragmentation chain transfer (RAFT) agent, then surface RAFT polymerization is conducted to get poly(2-(diethylamino)ethyl methacrylate)-b-poly(oligo(ethylene glycol) methacrylate)-coated SNTs (SNT-PDEAEMA-b-POEGMA). Doxorubicin (DOX) can be encapsulated in SNT-PDEAEMA-b-POEGMA, and controlled release of loaded DOX is achieved by adjusting pH of the medium. In vitro cell viability and cellular internalization study confirm the potential application of this nanocontainer in drug and gene delivery.
    ACS Applied Materials & Interfaces 01/2015; 7(6). DOI:10.1021/am507832n · 6.72 Impact Factor
  • Wen-Jian Zhang · Chun-Yan Hong · Cai-Yuan Pan
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    ABSTRACT: Multi-compartmental cylindrical microstructures with lots of nanotubes on their surface, whose shape resembles a sea cucumber, have been fabricated for the first time. This hierarchical morphology is formed through transitions of vesicles to large compound vesicles, to sea cucumber-like hierarchical microstructures. Along with the morphology transitions, aggregation of the residual polymer chains in the solution occurs, which is called multi-step self-assembling. The driving force of the phase transitions and the multistep self-assembling is polymerization because with the progress of the polymerization, the chain length ratio of PS to P4VP increases, which induces self-assembling and morphology transitions. The requisite for multi-step self-assembling is a high concentration of the P4VP-PS chains remaining in the solution after formation of the nascent assemblies. The concentration of the residual block chains can be controlled by varying the recipe and content of the ethanol. Thus, this study provides a unique strategy to fabricate useful hierarchical assemblies.
    RSC Advances 01/2015; 5(53):42637-42644. DOI:10.1039/C5RA05105C · 3.84 Impact Factor
  • Ze Zhang · Ye-Zi You · De-Cheng Wu · Chun-Yan Hong
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    ABSTRACT: Multicomponent reactions are of substantial significance not only for organic synthesis but also for polymer synthesis due to their more bond-forming events per synthetic operation. Generally due to that there are two or more reactions in one multicomponent reaction system, synergistic catalysis, in which the two or more reactions are activated by two or more different catalysts at the same time, is very important for achieving high-efficiency transformations. However, achieving synergistic catalysis via using two or more different catalyst simultaneously is a great challenge. Here, we propose a new reactant-synergistically catalyzed multicomponent reaction, in which the units coming from the reactant can synergistically catalyze the two reactions at the same time. Moreover, this multicomponent reaction can be extended to multicomponent polymerization, which is a very promising method for the preparation of functional polymers with defined-sequence.
    Polymer 12/2014; 64. DOI:10.1016/j.polymer.2014.12.012 · 3.77 Impact Factor
  • Lei Yu · Long-Hai Wang · Zong-Tao Hu · Ye-Zi You · Decheng Wu · Chun-Yan Hong
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    ABSTRACT: Sequential Michael addition-based thiol-ene and free radical mediated thiol-ene reactions for preparing sequence-ordered polymers are reported for the first time. The thiols are produced in situ via the ring-opening of thiolactones, and they can readily react with the electron-deficient carbon-carbon double bond of allyl methacrylate via Michael addition-based thiol-ene, but they are unable to react with the electron-rich carbon-carbon double bond of allyl methacrylate without radicals, and intermediates with thiol and alkene units are formed. After the Michael addition thiol-ene and ring-opening reactions are complete, the thiol is activated by UV irradiation, enabling reaction with the electron-rich carbon-carbon double bond via free radical-mediated thiol-ene reaction, to form sequence-ordered polymers of high molecular weights.
    12/2014; 6(9). DOI:10.1039/C4PY01363H
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    ABSTRACT: Generally, it is very difficult to control the size of large compound vesicles. Here, we introduce a novel method for the preparation of biodegradable large compound vesicles with controlled size and narrow size distribution by using aqueous nanodroplets as templates.
    Chemical Communications 07/2014; 50(68). DOI:10.1039/c4cc02836h · 6.83 Impact Factor
  • Zhi-Qiang Yu · Xiao-Man Xu · Chun-Yan Hong · De-Cheng Wu · Ye-Zi You
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    ABSTRACT: Though many responsive polymers have been prepared, none of them can both self-immolate and self-cross-link via responding to the changes of the environment. Here, we introduce a new responsive hyperbranched polymer, which not only can self-immolate but also can self-cross-link via responding to the external stimuli. Moreover, the obtained polymer can form a bioreducible nanogel in its aqueous solution simply via heating, and the formed nanogel can self-immolate via UV irradiation.
    Macromolecules 07/2014; 47(13):4136-4143. DOI:10.1021/ma5009012 · 5.93 Impact Factor
  • Ji-Gang Piao · Sheng-Gang Ding · Lu Yang · Chun-Yan Hong · Ye-Zi You
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    ABSTRACT: In this study, we have prepared a self-cross-linking PEG-based branched polymer, which easily forms a bioreducible nanoshell around polyplexes of cationic polymer and DNA, simply via heating the polyplex dispersions in the presence of the self-cross-linking branched polymer. This nanoshell can prevent the polyplex from dissociation and aggregation in physiological fluids without inhibiting the electrostatic interactions between the polymer and DNA. Furthermore, glutathione (GSH) can act as a stimulus to open the nanoshell after it has entered the cell. The polyplexes coated with the bioreducible nanoshell show an obvious enhancement in gene transfection in vivo compared with bare polyplexes.
    Biomacromolecules 06/2014; 15(8). DOI:10.1021/bm500518u · 5.75 Impact Factor
  • Wen-Jian Zhang · Chun-Yan Hong · Cai-Yuan Pan
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    ABSTRACT: Silica nanotubes with controlled diameters and lengths were fabricated by a template-directed method. Nanowires composed of poly(2-dimethylaminoethyl methacrylate)-block-polystyrene (PDMAEMA–PS), which were fabricated by RAFT dispersion polymerization of styrene in methanol using PDMAEMA as a macro-RAFT agent, were used as sacrificial templates. The diameter of the polymeric nanowires can be adjusted by changing the degree of polymerization (DP) of the hydrophilic PDMAEMA block. As the chain length of the hydrophilic PDMAEMA block increases, the DP of the PS block for formation of the nanowires increases, leading to the diameter increase of the corresponding nanowires. Moreover, the polymeric nanowires with controlled lengths and diameters of the core and the shell can be fabricated on a large scale through polymerization-induced self-assembly and reorganization, conveniently. The weak polyelectrolyte, PDMAEMA shell, is an ideal nanoreactor for deposition of silica to form hybrid nanowires. Silica nanotubes were prepared by calcination of the hybrid nanowires.
    05/2014; 2(21). DOI:10.1039/C4TA00465E
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    ABSTRACT: A new and easy method of stimuli-triggered growth and removal of a bioreducible nanoshell on nanoparticles is reported. The results show that pH or temperature could induce the aggregation of disulfide-contained branched polymers at the surface of nanoparticles; subsequently, the aggregated polymers could undergo intermolecular disulfide exchange to cross-link the aggregated polymers, forming a bioreducible polymer shell around nanoparticles. When these nanoparticles with a polymer shell are treated with glutathione (GSH) or d,l-dithiothreitol (DTT), the polymer shell could be easily removed from the nanoparticles. The potential application of this method is demonstrated by easily growing and removing a bioreducible shell from liposomes, and improvement of in vivo gene transfection activity of liposomes with a bioreducible PEG shell.
    Macromolecular Rapid Communications 03/2014; 35(6). DOI:10.1002/marc.201300885 · 4.61 Impact Factor
  • Wen-Jian Zhang · Chun-Yan Hong · Cai-Yuan Pan
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    ABSTRACT: Different from concentric vesicles without spacing between the walls, the concentric vesicles with uniform spacing between the walls were rarely fabricated. We successfully fabricate the spaced concentric vesicles (SCVs) via RAFT dispersion polymerization, and continuous propagation of the residual polymer chains inside the large vesicles induces self-assembling to form SCVs. Concentration of the residual polymer chains in the solution of the nascent-formed vesicles is the determining factor for formation of SCVs, and continuous propagation of less or too more residual polymer chains will not form SCVs but form other morphologies. Generally, the concentration of the residual polymer chains after formation of vesicles is too low to self-assemble, so formation of SCVs is impossible. By adjusting the ratio of St/methanol or macro-RAFT agent P4VP-b-PS/P4VP, the concentration of residual polymer chains can be controlled, and further control of the morphologies is achieved. Formation of the inner vesicles by self-assembling inside the large vesicles requires high molecular weight of the polymer chains due to their very low concentration. The polymers of inner vesicles possess very high molecular weight (×106 g/mol) in comparison with the polymer of outmost vesicles (×105 g/mol). Polymerization kinetic study reveals very high increasing rate of the molecular weight inside the vesicles probably owing to long duration of the chain radicals, and the polymerization rate (Rp) inside the vesicles is faster than the Rp in the outmost vesicles, but both rates are in the same order.
    Macromolecules 02/2014; 47(5):1664–1671. DOI:10.1021/ma402497y · 5.93 Impact Factor
  • Di Wang · Zhi-Qiang Yu · Chun-Yan Hong · Ye-Zi You
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    ABSTRACT: Hyperbranched poly(amido amine)s (HPAA) show weak photoluminescence, however, they have shown strong emission after short polyethylene glycol (PEG) chains have been linked onto HPAA macromolecule via Michael addition reaction. These PEGylated hyperbranched poly(amido amine)s show low cytotoxicity and potential application in cell imaging.
    European Polymer Journal 12/2013; 49(12):4189–4194. DOI:10.1016/j.eurpolymj.2013.09.029 · 3.24 Impact Factor
  • Source
    Jun-Jie Yan · Jiao-Tong Sun · Ye-Zi You · De-Cheng Wu · Chun-Yan Hong
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    ABSTRACT: In nature, a sapling can grow into a big tree under irradiation of sunlight. In chemistry, a similar concept that a small molecule only exposing to sunlight grows into a hyperbranched macromolecule has not been realized by now. The achievement of the concept will be fascinating and valuable for polymer synthesis wherein sunlight is inexpensive, abundant, renewable, and nonpolluting. Herein, we report a new strategy in which small monomers can directly grow into big hyperbranched macromolecule under irradiation of sunlight without any catalyst.
    Scientific Reports 10/2013; 3:2841. DOI:10.1038/srep02841 · 5.58 Impact Factor
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    ABSTRACT: A versatile one-pot strategy for the preparation of reversibly cross-linked polymer-coated mesoporous silica nanoparticles (MSNs) via surface reversible addition-fragmentation chain transfer (RAFT) polymerization is presented for the first time in this paper. The less reactive monomer oligo(ethylene glycol) acrylate (OEGA) and the more reactive cross-linker N,N'-cystaminebismethacrylamide (CBMA) are chosen to be copolymerized on the external surfaces of RAFT agent-functionalized MSNs to form the cross-linked polymer shells. Owing to the reversible cleavage and restoration of disulfide bonds via reduction/oxidation reactions, the polymer shells can control the on/off switching of the nanopores and regulate the drug loading and release. The redox-responsive release of doxorubicin (DOX) from this drug carrier is realized. The protein adsorption, in vitro cytotoxicity assays, and endocytosis studies demonstrate that this biocompatible vehicle is a potential candidate for delivering drugs. It is expected that this versatile grafting strategy may help fabricate satisfying MSN-based drug delivery systems for clinical application.
    Macromolecular Rapid Communications 09/2013; 34(17). DOI:10.1002/marc.201300477 · 4.61 Impact Factor
  • Ying Wang · Chun-Yan Hong · Cai-Yuan Pan
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    ABSTRACT: Redox-responsive amphiphilic diblock copolymers, poly(6-O-methacryloyl-d-galactopyranose-co-2-(N,N-dimethylaminoethyl) methacrylate)-b-poly(pyridyl disulfide ethyl methylacrylate) (P(MAGP-co-DMAEMA)-b-PPDSMA) were obtained by deprotection of poly((6-O-methacryloyl-1,2:3,4-di-O-isopropylidene-d-galactopyranose)-co-DMAEMA)-b-PPDSMA [P(MAlpGP-co-DMAEMA)-b-PPDSMA], which were prepared via reversible addition-fragmentation chain transfer (RAFT) polymerization of PDSMA using P(MAlpGP-co-DMAEMA) as macro-RAFT agent. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) studies showed that diblock copolymers P(MAGP-co-DMAEMA)-b-PPDSMA can self-assemble into micelles. Doxorubicin (DOX) could be encapsulated by P(MAGP-co-DMAEMA)-b-PPDSMA upon micellization and released upon adding glutathione (GSH) into the micelle solution. The galactose functional groups in the PMAGP block had specific interaction with HepG2 cells, and P(MAGP-co-DMAEMA)-b-PPDSMA can act as gene delivery vehicle. So, this kind of polymer has potential applications in hepatoma-targeting drug and gene delivery and biodetection.
    Biomacromolecules 04/2013; 14(5). DOI:10.1021/bm4003078 · 5.75 Impact Factor
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    ABSTRACT: A novel and versatile method for one-pot and in situ generation of bioreducible and acid labile nanogels/microgels simply via adding water into the polymerization system is reported. The produced polymers in the polymerization system become temperature-sensitive and less soluble after adding water, and hence they collapse together, forming nanoparticles. Subsequently, the disulfides inside the nanoparticle undergo intermolecular disulfide exchange to crosslink the nanoparticle into a bioreducible and acid labile nanogel/microgel. The size of the nanogel/microgel can be easily controlled by the polymerization time and the amount of water added. The formed nanogel/microgel is redox and pH responsive, and biocompatible.
    02/2013; 4(5):1694-1699. DOI:10.1039/C2PY21058D
  • Jiao-Tong Sun · Chun-Yan Hong · Cai-Yuan Pan
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    ABSTRACT: Differently from bulk, solution, suspension, emulsion, and miniemulsion polymerizations, the controlled radical dispersion polymerization (CRDP) demonstrates self-assembly of the block copolymers formed in the homogeneous system, forming various kinds of micelles or vesicles. Thus, this technology can prepare both the block copolymers and the polymeric aggregates directly. Among CRDP, the reversible addition-fragmentation chain transfer (RAFT) dispersion polymerization has been studied in relative detail and has been successfully developed to prepare a diverse range of assemblies. Several typical systems for RAFT dispersion polymerization are presented in detail and the factors influencing the polymerization and the in situ self-assembly are also highlighted in this minireview.
    01/2013; 4(4):873-881. DOI:10.1039/C2PY20612A