Yijun Chen

Publications (2)5.11 Total impact

• Article: Core-modified sordaricin derivatives: synthesis and antifungal activity.

  Alicia Regueiro-Ren, Tina M Carroll, Yijun Chen, James A Matson, Stella Huang, Charles E Mazzucco, Terry M Stickle, Dolatrai M Vyas, Balu N Balasubramanian
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  ABSTRACT: Core-modified sordaricin derivatives were prepared via biotransformation followed by chemical modification and tested for antifungal activity. The antifungal activity proved to be very sensitive to modifications in the sterics and/or lipophilicity of the diterpene skeleton. Introduction of polar groups such as hydroxyl in the diterpene core results in loss of potency while small and lipophilic groups such as fluorine and the 7,8-olefin are well tolerated.
  Bioorganic & Medicinal Chemistry Letters 01/2003; 12(23):3403-5. · 2.55 Impact Factor
• Article: Sordarin oxazepine derivatives as potent antifungal agents.

  Michael H Serrano-Wu, Denis R St Laurent, Yijun Chen, Stella Huang, Kin-Ray Lam, James A Matson, Charles E Mazzucco, Terry M Stickle, Thomas P Tully, Henry S Wong, Dolatrai M Vyas, Balu N Balasubramanian
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  ABSTRACT: The synthesis and biological activity of sordarin oxazepine derivatives are described. The key step features a regioselective oxidation of an unprotected triol followed by double reductive amination to afford the ring-closed products. The spectrum of antifungal activity for these novel derivatives includes coverage of Candida albicans, Candida glabrata, and Cryptococcus neoformans.
  Bioorganic & Medicinal Chemistry Letters 11/2002; 12(19):2757-60. · 2.55 Impact Factor