P Varjo

Satakunta Hospital District, Björneborg, Province of Western Finland, Finland

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Publications (6)3.78 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: In our preliminary study four years ago, using vascular closure staple (VCS) clips in making arterial anastomoses in peripheral vascular reconstructions, we showed that clip closure is easy and safe in early long-term (an average of 11 months) follow-up. In the present study we re-examined all the patients who had been bypassed using VCS clips in our earlier study. All together, ten of 17 patients were clinically examined, the ankle brachial index was measured, and a duplex Doppler examination was performed. The mean ankle brachial index in the operated leg of seven patients was 1.01 (range, 0.78–1.52). The anastomoses of nine patients were patent and neither turbulent blood flow nor aneurysms were seen. Only a PTFE prosthesis was occluded. The long-term experience of using metal clips in the peripheral vascular reconstructions seems to be encouraging, because the patency of grafts is good and no adverse reactions, such as aneurysms, were seen during the four-year surveillance period.
    International Journal of Angiology 01/2004; 13(3):113-115. DOI:10.1007/s00547-004-1057-z
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    ABSTRACT: The aim was to evaluate clinical and subclinical cardiac toxicity of epirubicin-docetaxel (ET) combination. Breast cancer patients were given epirubicin (75 mg/m2 for 15 min), followed 1 h later by a 1-h infusion of docetaxel (75 mg/m2) q3w as first-line treatment. Cardiac function was monitored using a 24-h ambulatory electrocardiogram (ECG), left ventricular ejection fraction (LVEF), physical examination and chest radiography. The median LVEF did not decrease during the course of the treatment: median LVEF was 64% prior to treatment and 68% after cycle 8. The 24-h ECG did not reveal any significant changes in heart rate variability. The number of extrasystoles or cardiac arrhythmia did not increase with the ET treatment. No patient experienced congestive heart failure during treatment or the mean follow-up of 34 months. We conclude that first-line ET caused no major cardiac changes during 6 months of treatment (8 cycles) or during follow-up. Twenty-four-hour ECG, combined with echocardiography to measure LVEF, was a feasible method for the close monitoring of the cardiac effects during chemotherapy.
    Anti-Cancer Drugs 02/2003; 14(1):73-7. DOI:10.1097/00001813-200301000-00010 · 1.89 Impact Factor
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    ABSTRACT: The purpose of this investigation was to evaluate the efficacy and toxicity of 6 months' treatment with the combination of epirubicin and docetaxel in metastatic breast cancer. Thirty-eight women (mean age 51 years, range 35-72) with metastatic breast cancer were treated with a regimen of epirubicin 75 mg/m and docetaxel 75 mg/m every 3 weeks, given 4 times if progression was seen upon evaluation after 4 courses or 8 times in responding/stable patients. The patients received 285 cycles of combination treatment and two treatments with docetaxel or epirubicin alone. When neutropenia with fever was observed, further cycles were given with dose reduction. The median cumulative docetaxel dose was 462 mg/m (range 199-600) and that of epirubicin 476 mg/m (range 199-740). The overall response rate was 54% (95% CI 37-71), with a median duration of response of 14.8 months (95% CI 8.8-27.8). Median time to progression was 12 months, median survival 26 months. Neutropenia below 0.5 x 10 /l occurred following 113 (39%) of the total of 285 cycles given; 21 patients (55%) were hospitalized for febrile neutropenia. We conclude that dose tailoring is required in treatment with an epirubicin and docetaxel regimen to avoid grade 3/4 adverse effects in a significant number of patients treated for metastatic breast cancer.
    Anti-Cancer Drugs 11/2002; 13(9):925-9. DOI:10.1097/00001813-200210000-00004 · 1.89 Impact Factor
  • International Journal of Angiology 09/2001; 10(4). DOI:10.1007/BF01637050
  • P Aarnio, O Järvinen, P Varjo
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    ABSTRACT: The vascular anastomoses are usually made with sutures. Some mainly experimental studies have been published about a new method of doing the vascular anastomoses with metal clips. We studied the suitability of vascular closure staple (VCS) clip applier system for making the anastomoses in femoropopliteal and femorotibial arterial reconstruction. During an 11-month period, VCS clips were used in 17 out of 27 patients who were operated due to severe claudication or incipient gangrena of the foot. Altogether 26 anastomoses were made with VCS clips using either great saphenous vein or PTFE graft. The making of anastomosis was easy and reliable. No postoperative bleeding was noticed. All anastomoses were patent 4-6 weeks postoperatively studied by palpation and measured by ankle brachial pressure index (mean 0.96). In Duplex Doppler examination all studied patients had well patent anastomoses on an average 11 months after the operation. With VCS clip applier system, it is possible to do anastomoses in arteriosclerotic arteries like in femoropopliteal reconstructions. This method helps making reliable anastomoses more easily.
    International Journal of Angiology 04/2000; 9(2):62-64.
  • [Show abstract] [Hide abstract]
    ABSTRACT: The vascular anastomoses are usually made with sutures. Some mainly experimental studies have been published about a new method of doing the vascular anastomoses with metal clips. We studied the suitability of vascular closure staple (VCS) clip applier system for making the anastomoses in femoropopliteal and femorotibial arterial reconstruction. During an 11-month period, VCS clips were used in 17 out of 27 patients who were operated due to severe claudication or incipient gangrena of the foot. Altogether 26 anastomoses were made with VCS clips using either great saphenous vein or PTFE graft. The making of anastomosis was easy and reliable. No postoperative bleeding was noticed. All anastomoses were patent 4–6 weeks postoperatively studied by palpation and measured by ankle brachial pressure index (mean 0.96). In Duplex Doppler examination all studied patients had well patent anastomoses on an average 11 months after the operation. With VCS clip applier system, it is possible to do anastomoses in arteriosclerotic arteries like in femoropopliteal reconstructions. This method helps making reliable anastomoses more easily.
    International Journal of Angiology 02/2000; 9(2):62-64. DOI:10.1007/BF01617041