A Hickman

Publications (2)6.85 Total impact

• Source

  Available from: Steven L Coon

  Article: 14-3-3 proteins in pineal photoneuroendocrine transduction: how many roles?

  D C Klein, S Ganguly, S L Coon, Q Shi, P Gaildrat, F Morin, J L Weller, T Obsil, A Hickman, F Dyda
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  ABSTRACT: Recent studies suggest that a common theme links the diverse elements of pineal photoneuroendocrine transduction--regulation via binding to 14-3-3 proteins. The elements include photoreception, neurotransmission, signal transduction and the synthesis of melatonin from tryptophan. We review general aspects of 14-3-3 proteins and their biological function as binding partners, and also focus on their roles in pineal photoneuroendocrine transduction.
  Journal of Neuroendocrinology 05/2003; 15(4):370-7. · 3.14 Impact Factor
• Source

  Available from: biochemsoctrans.cn

  Article: 14-3-3 Proteins and photoneuroendocrine transduction: role in controlling the daily rhythm in melatonin.

  D C Klein, S Ganguly, S Coon, J L Weller, T Obsil, A Hickman, F Dyda
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  ABSTRACT: This paper describes the role 14-3-3 proteins play in vertebrate photoneuroendocrine transduction. 14-3-3 proteins form a complex with arylalkylamine N-acetyltransferase (AANAT), the enzyme which turns melatonin production on during the day and off at night. Complex formation is triggered at night by cAMP-dependent phosphorylation of the enzyme, and results in activation and protection against proteolysis. This enhances melatonin production >10-fold. Light exposure results in dephosphorylation of the enzyme and disassociation from 14-3-3, leading to destruction and a rapid drop in melatonin production and release and circulating levels.
  Biochemical Society Transactions 09/2002; 30(4):365-73. · 3.71 Impact Factor