Iris Nöbauer-Huhmann

Medical University of Vienna, Wien, Vienna, Austria

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Publications (35)79.27 Total impact

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    ABSTRACT: Multimodal treatment regimens for Ewing's sarcoma have led to survival rates approaching 70% of patients with no metastases at diagnosis. However, these treatments have long-term side effects. Low bone mineral density (BMD) and risk of fractures can occur owing in part to chemotherapy and limited mobility from local control of the primary tumor.
    Clinical Orthopaedics and Related Research 07/2014; · 2.79 Impact Factor
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    ABSTRACT: Introduction: This diffusion tensor MR imaging (DTI) study aimed to clarify the relationship of peripheral nerves and soft tissue tumors (STT) in 3D to optimize subsequent treatment. Methods: 26 consecutive STT patients (histologically malignant n=10, intermediate n=3, and benign n=13) underwent 3 Tesla MRI using an echoplanar DTI sequence. Deterministic tractography was performed. Fractional Anisotropy (FA) values were measured within peritumoral and distant ROIs. Results: Tractography depicted the 3D course of the sciatic (n=12), femoral (n=2), tibial (n=7), fibular (n=2), median (n=1), musculocutaneous (n=1), and ulnar (n=1) nerves in a regular (n=8/18, 44.4%) or thinned (n=7/18, 38.9%) fashion. The lowest peritumoral FA values, abrupt thinning, and/or complete discontinuity of trajectories were found in 2 cases with histologically proven tumoral nerve infiltration. Discussion: DTI clarifies the 3D topography between major peripheral nerves and STT and may be helpful in the assessment of peripheral nerve infiltration by malignant tumors. © 2014 Wiley Periodicals, Inc.
    Muscle & Nerve 06/2014; · 2.31 Impact Factor
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    ABSTRACT: OBJECTIVE: To quantitatively evaluate position, size, and shape of the menisci in subjects with radiographic knee osteoarthritis (OA) compared to subjects free of OA using magnetic resonance (MR) imaging. METHODS: We studied right knees from 39 Osteoarthritis Initiative participants (24 women, 15 men; mean age 59.6±8.7 years) with medial compartment radiographic tibiofemoral OA (Kellgren Lawrence grade 2 or 3). We matched them individually by age, sex and body height with right knees of subjects without knee OA and without risk factors for knee OA as references. One observer performed manual segmentation of the tibial plateau and the medial and lateral meniscus based on coronally reconstructed DESSwe focusing on 5 central 3T MR images. RESULTS: Meniscal coverage of the medial tibial plateau was less in OA knees (40.5% vs. 49.8%; p<0.0001), the medial meniscus body showed more extrusion (2.64 vs. 0.53mm; p<0.0001) and the peripheral margin had a more convex shape, i.e., bulged more (mean 0.61 vs. 0.27mm, p<0.0001). The thickness or volume of the medial meniscus body of OA knees did not differ substantially. In contrast the lateral meniscus body had a larger volume (mean 266 vs. 224mm(3) ; p=0.0005), extruded more (mean 1.16 vs. -1.01mm; p<0.0001) and the external margin bulged more (mean 0.53 vs. 0.35mm; p<0.0001)in OA than in reference knees. CONCLUSIONS: The study provides evidence for altered meniscal position and shape (i.e.,more bulging in OA knees) in both compartments in medial compartment knee OA. These changes may be important features of OA pathogenesis and/or disease consequences. © 2013 American College of Rheumatology.
    Arthritis & Rheumatology 03/2013; · 7.48 Impact Factor
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    Osteoarthritis and Cartilage 09/2012; 20(9):1056. · 4.26 Impact Factor
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    ABSTRACT: BACKGROUND AND PURPOSE:Patients with cervical spine syndrome often experience pain during the MR examination. Our aim was to compare the quality of cervical spine MR images obtained by parallel imaging with those of nonaccelerated images, with the goal of shortening the examination time while preserving adequate image quality.MATERIALS AND METHODS:A phantom study and examinations of 10 volunteers and 26 patients were conducted on a clinical 3T scanner. Acquisitions included axial T2WI, sagittal T2WI, T1WI, and T2TIRM sequences. Nonaccelerated sequences and accelerated sequences with different numbers of averages and different accelerations, with a scanning time reduction of 67%, were performed. For quantitative analysis, the SNR was obtained from the phantom measurements, and the NU was calculated from the volunteer measurements. For qualitative analysis, 3 independent readers assessed the delineation of anatomic structures in volunteers and the visibility of degenerative disease in patients.RESULTS:In the phantom study, as expected, the SNR of the nonaccelerated images was higher than the SNR of the same sequence with parallel imaging. In vivo, the NU was higher when applying fewer averages or parallel imaging, compared with the nonaccelerated images. The analysis of the subjective parameters in the volunteers and patients showed that a scanning time of 48% of the original protocol could be obtained by combining the following sequences: sagittal T1WI with 1 average; sagittal T2WI with acceleration factor 3; sagittal T2TIRM with acceleration factor 2; and axial T2* GRE with acceleration factor 2.CONCLUSIONS:Parallel imaging of the cervical spine at 3T allows shortening of the examination time by 52%, preserving adequate image quality.
    American Journal of Neuroradiology 05/2012; · 3.17 Impact Factor
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    ABSTRACT: The objective was to compare patients after matrix-associated autologous chondrocyte transplantation (MACT) and microfracture therapy (MFX) of the talus using diffusion-weighted imaging (DWI), with morphological and clinical scoring. Twenty patients treated with MACT or MFX (10 per group) were examined using 3 T magnetic resonance imaging (MRI) at 48 ± 21.5 and 59.6 ± 23 months after surgery, respectively. For comparability, patients from each group were matched by age, body mass index, and follow-up. American Orthopaedic Foot and Ankle Society (AOFAS) score served as clinical assessment tool pre- and postoperatively. DWI was obtained using a partially balanced, steady-state gradient echo pulse sequence, as well as the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score, based on a 2D proton density-weighted turbo spin-echo sequence and a 3D isotropic true fast imaging with steady-state precession sequence. Semi-quantitative diffusion quotients were calculated after region of interest analysis of repair tissue (RT) and healthy control cartilage, and compared among both groups. The mean AOFAS score improved significantly (P = 0.001) for both groups (MACT: 48.8 ± 20.4-83.6 ± 9.7; MFX: 44.3 ± 16.5-77.6 ± 13.2). No differences in the AOFAS (P = 0.327) and MOCART (P = 0.720) score were observed between MACT and MFX postoperatively. DWI distinguished between healthy cartilage and cartilage RT in the MFX group (P = 0.016), but not after MACT treatment (P = 0.105). Significant correlations were found between MOCART score and DWI index after MFX (Pearson: -0.648; P = 0.043), and between the diffusivity and longer follow-up interval in MACT group (Pearson: -0.647, P = 0.043). Whereas conventional scores reveal a similar outcome after MACT or MFX treatment in the ankle joint, DWI was able to distinguish between different RT qualities, as reported histologically for these diverse surgical procedures.
    Osteoarthritis and Cartilage 03/2012; 20(7):703-11. · 4.26 Impact Factor
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    ABSTRACT: PURPOSE/INTRODUCTION: The aim of this study was to determine the T1 relaxivities (r1) of 8 gadolinium (Gd)-based MR contrast agents in human blood plasma at 7 Tesla, compared with 3 Tesla. Eight commercially available Gd-based MR contrast agents were diluted in human blood plasma to concentrations of 0, 0.25, 0.5, 1, and 2 mmol/L. In vitro measurements were performed at 37 degrees C, on a 7 Tesla and on a 3 Tesla whole-body magnetic resonance imaging scanner. For the determination of T1 relaxation times, Inversion Recovery Sequences with inversion times from 0 to 3500 ms were used. The relaxivities were calculated. The r1 relaxivities of all agents, diluted in human blood plasma at body temperature, were lower at 7 Tesla than at 3 Tesla. The values at 3 Tesla were comparable to those published earlier. Notably, in some agents, a minor negative correlation of r1 with a concentration of up to 2 mmol/L could be observed. This was most pronounced in the agents with the highest protein-binding capacity. At 7 Tesla, the in vitro r1 relaxivities of Gd-based contrast agents in human blood plasma are lower than those at 3 Tesla. This work may serve as a basis for the application of Gd-based MR contrast agents at 7 Tesla. Further studies are required to optimize the contrast agent dose in vivo.
    Investigative radiology 09/2010; 45(9):554-8. · 4.85 Impact Factor
  • Iris Noebauer-Huhmann
    European Journal of Radiology. 06/2010; 74(3):e200.
  • Iris Noebauer-Huhmann
    European Journal of Radiology - EUR J RADIOL. 01/2010; 74(1).
  • Iris Noebauer-Huhmann
    European Journal of Radiology - EUR J RADIOL. 01/2010; 74(3).
  • Sonja Plischke, Iris Nöbauer-Huhmann
    European Journal of Radiology - EUR J RADIOL. 01/2010; 74(3).
  • H Imhof, I Nöbauer-Huhmann, S Trattnig
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    ABSTRACT: Degenerative osteoarthritis of the hip joint (coxarthrosis) is the most common disease of the hip joint in adults. The diagnosis is based on a combination of radiographic findings and characteristic clinical symptoms. The lack of a radiographic consensus definition has seemingly resulted in a variation of the published incidences and prevalence of degenerative osteoarthritis of the hip joint. The chronological sequence of degeneration includes the following basic symptoms on conventional radiographs and CT: joint space narrowing, development of osteophytes, subchondral demineralisation/sclerosis and cyst formation, as well as loose bodies, joint malalignment and deformity. MR imaging allows additional visualization of early symptoms and/or activity signs such as cartilage edema, cartilage tears and defects, subchondral bone marrow edema, synovial edema and thickening, joint effusion and muscle atrophy.The scientific dispute concerns the significance of (minimal) joint malalignment (e.g. impingement, dysplasia etc.) and forms of malpositioning which as possible prearthrosis have a high probability of leading to degenerative osteoarthritis. Moreover, without any question, the preservation of joint containment and gender differences are important additional basic diagnostic principles, which have gained great interest in recent years.In research different MR procedures such as Na and H spectroscopy, T2*-mapping etc. with ultrahigh field MR allow cartilage metabolism and its changes in early degenerative osteoarthritis ("biochemical imaging") to be studied. There is no doubt that even in a few years new profound knowledge is to be expected in this field.
    Der Radiologe 06/2009; 49(5):400-9. · 0.47 Impact Factor
  • Marcus Köller, Iris Nöbauer-Huhmann
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    ABSTRACT: Rheumatoid Arthritis (RA) is the most prevalent inflammatory joint disease in adults and shows a destructive course in most cases. The outcome of the disease - functional decline and invalidity - necessitates an early therapy. Recent studies demonstrate that the initiation of the treatment with a disease modifying antirheumatic drug (DMARD) treatment within the first three months after the onset of symptoms is crucial for sustained improvement of prognosis as well as therapeutic success and outcome. In the early stage of the disease, the criteria for the classification of Rheumatoid Arthritis (RA) are frequently not met. Up to over 50% of the patients show an arthritis, which cannot be classified and therefore is seen as undifferentiated arthritis (UA). Early therapeutic intervention appears to prevent the chronification of the disease; thus an early and appropriate disease modifying therapy is mandatory. Age, gender, involvement of the hands, positive rheumatoid factor, as well as the detection of anti cyclic-citrullinated peptide antibodies (anti-CCP Ab) are predictors of the development of RA. Beside conventional X-rays, there are other imaging methods such as magnetic resonance tomography imaging, Power-Doppler or contrast medium enhanced sonography, which may enable the detection not only of synovitis but also of erosive lesions at very early stages. Those patients suffering from UA carry a high risk for the development of a destructive arthritis as seen in RA, and therefore should be treated with an adequate DMARD. In these cases methotrexate is still the drug of first choice.
    Wiener Medizinische Wochenschrift 02/2009; 159(3-4):66-9.
  • Marcus Köller, Iris Nöbauer-Huhmann
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    ABSTRACT: Die Rheumatoide Arthritis (RA) stellt die häufigste entzündliche Gelenkerkrankung im Erwachsenenalter dar und zeigt meist einen destruierenden Verlauf. Die Folgen der Erkrankung – Funktionseinbußen bis hin zur Invalidität – machen eine frühe Therapie erforderlich. Die Studienergebnisse der letzten Jahre zeigen, dass ein Behandlungsbeginn innerhalb der ersten 3 Monate nach Einsetzen der Beschwerden für eine nachhaltige Verbesserung der Prognose und des Therapieerfolges wichtig ist. In der Frühphase der Erkrankung sind die Kriterien zur Klassifikation einer RA meist nicht erfüllt. Eine frühe therapeutische Intervention eröffnet generell die Möglichkeit, eine Chronifizierung der Arthritis zu verhindern. Daher ist aus heutiger Sicht die Entscheidung für eine rasche adäquate krankheitsmodulierende Therapie je nach Risikoprofil wichtig. Alter, Geschlecht, Befall der Hände, positiver Rheumafaktor sowie der Nachweis von Antikörpern gegen cyklisches citrulliniertes Peptid (anti-CCP Ak) sind Prädiktoren für die Entwicklung einer RA. Neben den nativradiologischen Untersuchungen stehen mit der Magnetresonanztomographie, Power-Doppler- oder Kontrastmittel-Sonographie Verfahren zur Verfügung, die sowohl eine Synovitis als auch erosive Veränderungen in sehr frühen Phasen erfassen können. Bei Patientiennen mit nicht-klassifizierbaren, sog. undifferenzierten Arthritiden, bei denen ein hohes Risiko für die Entwicklung eines destruierenden Arthritis im Sinne einer RA besteht, sollte eine adäquate Basistherapie, am besten mit Methotrexat, begonnen werden. Rheumatoid Arthritis (RA) is the most prevalent inflammatory joint disease in adults and shows a destructive course in most cases. The outcome of the disease – functional decline and invalidity – necessitates an early therapy. Recent studies demonstrate that the initiation of the treatment with a disease modifying antirheumatic drug (DMARD) treatment within the first three months after the onset of symptoms is crucial for sustained improvement of prognosis as well as therapeutic success and outcome. In the early stage of the disease, the criteria for the classification of Rheumatoid Arthritis (RA) are frequently not met. Up to over 50% of the patients show an arthritis, which cannot be classified and therefore is seen as undifferentiated arthritis (UA). Early therapeutic intervention appears to prevent the chronification of the disease; thus an early and appropriate disease modifying therapy is mandatory. Age, gender, involvement of the hands, positive rheumatoid factor, as well as the detection of anti cyclic-citrullinated peptide antibodies (anti-CCP Ab) are predictors of the development of RA. Beside conventional X-rays, there are other imaging methods such as magnetic resonance tomography imaging, Power-Doppler or contrast medium enhanced sonography, which may enable the detection not only of synovitis but also of erosive lesions at very early stages. Those patients suffering from UA carry a high risk for the development of a destructive arthritis as seen in RA, and therefore should be treated with an adequate DMARD. In these cases methotrexate is still the drug of first choice.
    Wiener Medizinische Wochenschrift 01/2009; 159(3):66-69.
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    ABSTRACT: The spectrum of pathological changes in anatomical sections of the hypopharynx ranges from benign pathologies to hypopharyngeal carcinoma. Beside the clinical status and the endoscopic evaluation performed by ear, nose and throat specialists, imaging techniques play an important role in pre-therapeutic and post-therapeutic diagnostics and in the follow-up of pharyngeal disease patterns, especially for malignant lesions. A conventional x-ray swallow examination, contrast-enhanced multidetector computed tomography (MDCT) and magnetic resonance imaging (MRI), as well as positron emission tomography (PET) and positron emission tomography computed tomography (PET-CT) are applied depending on the medical question and disease. Especially in radiological oncology, it is extremely important in regions which are clinically difficult to assess to determine the exact localization and extent of hypopharyngeal pathologies to plan the optimal therapy for the patient. This article demonstrates the radiological appearance of pathological changes of the hypopharynx and discusses in particular the hypopharynx carcinoma in the focus of pre-therapeutic and post-therapeutic imaging.
    Der Radiologe 12/2008; 49(1):36-42. · 0.47 Impact Factor
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    ABSTRACT: The larynx and the pharynx represent anatomically as well as functionally a very complex organ which serves as an airway and a nutrition channel. Knowledge of anatomy and anatomical topography is therefore a fundamental basis for the evaluation of any pathological process. Beside the clinical examination and endoscopy performed by ear, nose and throat specialists, imaging techniques play a crucial role in pre-therapeutic and post-therapeutic diagnostics. The radiologist employs a conventional x-ray swallow examination, as well as contrast-enhanced multidetector computed tomography (MDCT), magnetic resonance imaging (MRI), positron emission tomography (PET) and positron emission tomography-computed tomography (PET-CT), depending on the medical problem in question. The following article demonstrates the functional and especially the structural anatomy of the larynx and the pharynx. Furthermore, the broad range of imaging techniques in clinical use is discussed.
    Der Radiologe 12/2008; 49(1):8-16. · 0.47 Impact Factor
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    ABSTRACT: To demonstrate intratumoral susceptibility effects in malignant brain tumors and to assess visualization of susceptibility effects before and after administration of the paramagnetic contrast agent MultiHance (gadobenate dimeglumine; Bracco Imaging), an agent known to have high relaxivity, with respect to susceptibility effects, image quality, and reduction of scan time. Included in the study were 19 patients with malignant brain tumors who underwent high-resolution, susceptibility-weighted (SW) MR imaging at 3 T before and after administration of contrast agent. In all patients, Multihance was administered intravenously as a bolus (0.1 mmol/kg body weight). MR images were individually evaluated by two radiologists with previous experience in the evaluation of pre- and postcontrast 3-T SW MR images with respect to susceptibility effects, image quality, and reduction of scan time. In the 19 patients 21 tumors were diagnosed, of which 18 demonstrated intralesional susceptibility effects both in pre- and postcontrast SW images, and 19 demonstrated contrast enhancement in both SW images and T1-weighted spin-echo MR images. Conspicuity of susceptibility effects and image quality were improved in postcontrast images compared with precontrast images and the scan time was also reduced due to decreased TE values from 9 min (precontrast) to 7 min (postcontrast). The intravenous administration of MultiHance, an agent with high relaxivity, allowed a reduction of scan time from 9 min to 7 min while preserving excellent susceptibility effects and image quality in SW images obtained at 3 T. Contrast enhancement and intralesional susceptibility effects can be assessed in one sequence.
    Neuroradiology 02/2008; 50(1):9-16. · 2.70 Impact Factor
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    ABSTRACT: The objectives of our study were to assess whether coronal reformations improve the diagnostic performance of MDCT in patients with acute flank pain and suspected urinary stone disease; and to determine if performing such reformations from 3-mm-thick sections is sufficient or if it is necessary to perform reformations from thinner sections. We included 147 consecutive patients (72 women and 75 men; mean age +/- SD, 58 +/- 18.1 years) with suspected urinary stone disease who underwent unenhanced MDCT. Scans were obtained with a 4 x 1 mm collimation and were reconstructed with a section thickness of 1.25 and 3 mm. We compared the diagnostic yield of 3-mm axial sections with that of coronal reformations reconstructed from 1.25- and 3-mm axial sections. Imaging data were evaluated in random order by two radiologists. The significance of the difference between the axial sections and coronal multiplanar reformations (MPRs) was tested for the number, size, and location of uroliths and for the presence of alternative diagnoses. The time required for review by both observers was recorded. We found uroliths in 72 patients. There was no difference between 3-mm axial sections and coronal reformations from 1.25-mm sections with regard to the number of detected stones (n = 264 for both protocols), whereas coronal reformations from 3-mm sections revealed significantly fewer calcifications (n = 255, p = 0.016). Coronal reformations did not improve the localization of calcifications. Review time, however, was significantly shorter for coronal reformations than for axial sections (p = 0.001); however, coronal reformations were less sensitive than axial sections for the detection of additional findings suggestive of alternative diagnoses in 16 (30%) of 53 patients. Coronal reformations from MDCT do not improve urinary stone detection but may reduce evaluation time; however, there is the danger of missing additional findings. Coronal reformations reconstructed from thick (i.e., 3-5 mm) axial sections may result in reduced detection of small stones and should therefore be avoided.
    American Journal of Roentgenology 09/2007; 189(2):W60-4. · 2.90 Impact Factor
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    ABSTRACT: The purpose of this work was to demonstrate susceptibility effects (SusE) in various types of brain tumors with 3T high-resolution (HR)-contrast-enhanced (CE)-susceptibility-weighted (SW)-MR imaging and to correlate SusE with positron-emission tomography (PET) and histopathology. Eighteen patients with brain tumors, scheduled for biopsy or tumor extirpation, underwent high-field (3T) MR imaging. In all of the patients, an axial T1-spin-echo (SE) sequence and an HR-SW imaging sequence before and after IV application of a standard dose of contrast agent (MultiHance) was obtained. Seven patients preoperatively underwent PET. The frequency and formation of intralesional SusE in all of the images were evaluated and correlated with tumor grade as determined by PET and histopathology. Direct correlation of SusE and histopathologic specimens was performed in 6 patients. Contrast enhancement of the lesions was assessed in both sequences. High-grade lesions demonstrated either high or medium frequency of SusE in 90% of the patients. Low-grade lesions demonstrated low frequency of SusE or no SusE. Correlation between intralesional frequency of SusE and histopathologic, as well as PET, tumor grading was statistically significant. Contrast enhancement was equally visible in both SW and SE sequences. Side-to-side comparison of tumor areas with high frequency of SusE and histopathology revealed that intralesional SusE reflected conglomerates of increased tumor microvascularity. 3T HR-CE-SW-MR imaging shows both intratumoral SusE not visible with standard MR imaging and contrast enhancement visible with standard MR imaging. Because frequency of intratumoral SusE correlates with tumor grade as determined by PET and histopathology, this novel technique is a promising tool for noninvasive differentiation of low-grade from high-grade brain tumors and for determination of an optimal area of biopsy for accurate tumor grading.
    American Journal of Neuroradiology 09/2007; 28(7):1280-6. · 3.17 Impact Factor
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    ABSTRACT: Multi-detector computed tomography (CT) offers new opportunities in the imaging of the gastrointestinal tract. Its ability to cover a large volume in a very short scan time, and in a single breath hold with thin collimation and isotropic voxels, allows the imaging of the entire esophagus with high-quality multiplanar reformation and 3D reconstruction. Proper distention of the esophagus and stomach (by oral administration of effervescent granules and water) and optimally timed administration of intravenous contrast material are required to detect and characterize disease. In contrast to endoscopy and double-contrast studies of the upper GI tract, CT provides information about both the esophageal wall and the extramural extent of disease. Preoperative staging of esophageal carcinoma appears to be the main indication for MDCT. In addition, MDCT allows detection of other esophageal malignancies, such as lymphoma and benign esophageal tumors, such as leiomyma. A diagnosis of rupture or fistula of the esophagus can be firmly established using MDCT. Furthermore, miscellaneous esophageal conditions, such as achalasia, esophagitis, diverticula, and varices, are incidental findings and can also be visualized with hydro-multi-detector CT. Multi-detector CT is a valuable tool for the evaluation of esophageal wall disease and serves as an adjunct to endoscopy.
    Abdominal Imaging 08/2007; 34(1):3-18. · 1.91 Impact Factor

Publication Stats

372 Citations
79.27 Total Impact Points

Institutions

  • 2007–2014
    • Medical University of Vienna
      • • Department of Biomedical Imaging and Image-guided Therapy
      • • Universitätsklinik für Radiodiagnostik
      • • Klinische Abteilung für Rheumatologie
      Wien, Vienna, Austria
  • 2012
    • Slovak Academy of Sciences
      Presburg, Bratislavský, Slovakia
  • 2005
    • University of Vienna
      Wien, Vienna, Austria