I Meral

Publications (8)8.92 Total impact

• Article: Diffusion changes in the vitreous humor of the eye during aging.

  I Meral, Y Bilgili
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  ABSTRACT: The inability to image the vitreous humor of the eye adequately hinders a complete understanding of its normal structure and the changes occurring in aging and disease. The purpose of the present study was to reveal normative data and age-related changes of the vitreous humor by using DWI. A total of 160 patients were enrolled in the present study. Patients were divided into 8 groups according to decade of age, and each group was of equal size with 20 patients. The ADCs were determined for each vitreous humor. Each determination was obtained by using average regions of interest of 50 ± 2 mm(2). ADC values were then plotted against age. The ADC values obtained from group 0 (0-10 years of age) were statistically different from those of all other groups (P < .05). Group 1 (11-20 years of age) was statistically different from groups 3, 5, 6, and 7 (P < .05). A trend toward increased ADC values with increasing age was not statistically significant. Besides the statistically significant difference between pediatric and adult patients, a statistically insignificant trend of increased ADC values among aging adults has been demonstrated. These normative data contribute to our understanding of how DWI can aid in the diagnosis of age-related changes in eye health and function.
  American Journal of Neuroradiology 07/2011; 32(8):1563-6. · 2.93 Impact Factor
• Article: Effects of Nigella sativa L. and Urtica dioica L. on lipid peroxidation, antioxidant enzyme systems and some liver enzymes in CCl4-treated rats.

  M Kanter, I Meral, S Dede, H Gunduz, M Cemek, H Ozbek, I Uygan
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  ABSTRACT: This study was designed to investigate the effects Nigella sativa L. (NS) and Urtica dioica L. (UD) on lipid peroxidation, antioxidant enzyme systems and some liver enzymes in carbon tetrachloride (CCl4)-treated rats. A total of 60 healthy male Sprague-Dawley rats were utilized in this study. The rats were randomly allotted into one of four experimental groups: A (CCl4-only treated), B (CCl4 + UD treated), C (CCl4 + NS treated) and D (CCl4 + UD + NS treated), each containing 15 animals. All groups received CCl4 [0.8 ml/kg of body weight, subcutaneously, twice a week for 90 days starting day 1]. In addition, B, C and D groups also received daily intraperitoneal injections of 0.2 ml/kg NS or/and 2 ml/kg UD oils for 45 days starting day 46. Group A, on the other hand, received only 2 ml/kg normal saline solution for 45 days starting day 46. Blood samples for the biochemical analysis were taken by cardiac puncture from five randomly chosen rats in each treatment group at beginning, at 45th and at 90th day of the experiment. The CCl4 treatment for 45 days increased the lipid peroxidation and liver enzymes, and also decreased the antioxidant enzyme levels. NS or UD treatments (alone or combination) for 45 days starting day 46 decreased the elevated lipid peroxidation and liver enzyme levels and also increased the reduced antioxidant enzyme levels. Live weights of the rats decreased in group A, and increased in groups B, C and D. It is concluded that NS and UD decrease the lipid peroxidation and liver enzymes, and increase the antioxidant defence system activity in the CCl4-treated rats.
  Journal of Veterinary Medicine Series A 06/2003; 50(5):264-8. · 0.93 Impact Factor
• Article: Kanter M, İ Meral, S Dede, M Cemek, H Özbek, İ Uygan, H Gündüz, “Effects of Nigella Sativa L. and Urtica Dioca L. on Lipid Peroxidation, Antioxidant Enzyme Systems and Some Liver Enzymes in CCl4-Treated Rats”. J Vet Med A, 50, 264-268 (2003).

  Kanter M, İ Meral, S Dede, M Cemek, H Özbek, İ Uygan, H Gündüz
  Journal of Veterinary Medicine Series A 01/2003; · 0.93 Impact Factor
• Article: Effects of increasing zinc supplementation in drinking water on growth and thyroid gland function and histology in broiler chicks.

  H H Dönmez, M A Karsl, I Meral, N Dönmez, N Simşek
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  ABSTRACT: The aim of the study was to examine the effects of increasing zinc supplementation on growth, feed efficiency and thyroid function and histology in broiler chicks. Sixty new born male broiler chicks were randomly allotted into one of four treatment groups and fed for 60 d. Zinc (Zn) was added into drinking water at the levels of 0, 125, 500, and 1000 mg Zn/L. Body weight gain were significantly higher and feed efficiency were significantly lower in chicks supplemented with 125 mg Zn/L compared with chicks supplemented with 500 or 1000 mg Zn/L at the end of the experiment. Serum Zn concentration linearly increased with the increasing level of Zn intake. Serum triiodothyronine and thyroxine levels and the diameters of follicles of thyroid gland were significantly reduced with high levels (500 and 1000 mg Zn/L) of Zn intake at the end of the experiment. It was concluded that chick receiving 1000 mg Zn/L as ZnSO4.7H2O in drinking water showed signs of Zn toxicity.
  DTW. Deutsche tierärztliche Wochenschrift 11/2002; 109(10):438-42. · 0.41 Impact Factor
• Article: Digoxin- and monensin-induced changes of intracellular Ca2+ concentration in isolated guinea-pig ventricular myocyte.

  I Meral, W Hsu, F B Hembrough
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  ABSTRACT: This study was undertaken to determine the possible mechanisms of actions of monensin and digoxin by using isolated guinea-pig ventricular myocytes. Since Ca2+ is the major signal for triggering contraction of cardiac muscle, the objective of this study was to determine whether monensin and digoxin affect the [Ca2+]i of cardiac myocytes and if so is this effect due to an increase in [Na+]i. Three different concentrations of digoxin (0.3, 1 and 3 micromol/l) and three different concentrations of monensin (0.3, 1 and 3 micromol/l) were used. Each treatment was monitored for two hours by using computerized fluoroscopy. Both digoxin and monensin increased the [Ca2+]i and accelerated the onset time of [Ca2+]i increase in a dose-dependent manner. Normal myocytes (loaded with fura-2 for 30 min before the treatment) were also compared with 'weakened' myocytes (loaded with fura-2 for 3 h before the treatment to create a 'weakened' condition). It was found that although 0.3 micromol/l monensin and digoxin did not change the [Ca2+]i in normal myocytes, they increased the [Ca2 +]i in 'weakened' myocytes. Finally, a Na+-free medium was used to demonstrate the effect of [Na+]o on both monensin- and digoxin-induced increases in [Ca2+]i. It was found that digoxin did not increase the [Ca2+]i in the Na+-free medium. Although monensin increased the [Ca2+]i in the Na+-free solution, this increase was not as large as in the Na+-containing medium. The results of the study led to the conclusion that the positive inotropic effect of digoxin depends on [Na+]o. However, monensin increases [Ca2+]i in Na+-dependent and -independent ways. An addition conclusion was that 'weakened' myocytes are more sensitive to the monensin and digoxin treatment than normal myocytes.
  Journal of Veterinary Medicine Series A 09/2002; 49(6):329-33. · 0.93 Impact Factor
• Article: Effect of short-term hypothermia on lipid peroxidation and antioxidant enzyme activity in rats.

  S Dede, Y Deger, I Meral
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  ABSTRACT: This experiment was carried out to determine the effect of short-term hypothermia on blood malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glucose-6-phosphate dehydrogenase (G-6-PD) concentrations in rats. Twenty Sprague-Dawley rats were used weighing 180-200 g and on average 3.5 months old. They were randomly divided into two experimental groups: control (without cooling) and hypothermic (with cooling). The rats of the hypothermic group were cooled by immersion into cold water (10-12 degrees C), and the control rats were immersed into water of body temperature (37 degrees C) up to the neck without using any anaesthetic or tranquilizer for 3 min Rectal body temperatures of both groups were measured and blood samples to analyse MDA, GSH, SOD, GSH, GSH-Px and G-6-PD were collected immediately after the treatment. It was found that the MDA level was higher and the GSH and G-6-PD levels were lower in the hypothermic group than those in the controls. There was no difference between the control or hypothermic group regarding SOD or GSH-Px levels. It is concluded that acute hypothermia increased the lipid peroxidation and decreased the GSH and G-6-PD levels in rats.
  Journal of Veterinary Medicine Series A 09/2002; 49(6):286-8. · 0.93 Impact Factor
• Article: Functional changes in isolated guinea-pig papillary muscle induced by monensin and digoxin.

  I Meral, F B Hembrough, T B Bailey, W Hsu
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  ABSTRACT: The effects of digoxin and monensin on contraction force (CF), initial contraction velocity (ICV), average contraction velocity (ACV), initial relaxation velocity (IRV) and stimulus to response time (ST) in 'fatigued' (tired) and 'non-fatigued' (fresh) guinea-pig papillary muscles were investigated. 'Fatigued' muscles had lost 30% of their original CF with the elapse of time before they were treated. The 5 h of measurement were divided into five periods (T0 was equilibration, T1, T2, T3 and T4 were, respectively, 1, 2, 3 and 4 h after drug administration). It was found that both monensin and digoxin increased the CF, ICV and ACV at T1 and increased the IRV at T2. Digoxin lost its effect with the elapse of time while monensin did not. Digoxin also decreased the ST at T2, T3 and T4. However, monensin did not change the ST. It was also found that 'fatigued' and 'non-fatigued' guinea-pig papillary muscles did not respond to the drug treatment differently. It was concluded that the initial effects of these two drugs on guinea-pig papillary muscles are similar regarding contractility but in time digoxin loses its effect while monensin does not.
  Journal of Veterinary Medicine Series A 03/2002; 49(1):51-6. · 0.93 Impact Factor
• Article: Effect of Nigella sativa on glucose concentration, lipid peroxidation, anti-oxidant defence system and liver damage in experimentally-induced diabetic rabbits.

  I Meral, Z Yener, T Kahraman, N Mert
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  ABSTRACT: This study was carried out to investigate whether Nigella sativa could decrease the lipid peroxidation, increase the anti-oxidant defence system and also prevent the lipid-peroxidation-induced liver damage in experimentally induced diabetic rabbits. Fifteen New Zealand male rabbits were divided into three experimental groups: control, diabetic and diabetic and N. sativa-treated. The diabetes mellitus (DMI) was induced in the rabbits using 150 mg/kg of 10% alloxan. The diabetic + N. sativa-treated group was given extract of N. sativa seeds orally every day for 2 months after induction of DM. At the end of the 2-month experiment, blood samples were collected to measure malondialdehyde (MDA), glutathione (GSH), ceruloplasmin and glucose concentration, and livers were harvested for histopathological analysis. Treatment with N. sativa decreased the elevated glucose and MDA concentrations, increased the lowered GSH and ceruloplasmin concentrations, and prevented lipid-peroxidation-induced liver damage in diabetic rabbits. It was concluded that N. sativa might be used in diabetic patients to prevent lipid peroxidation, increase anti-oxidant defence system activity and also prevent liver damage.
  Journal of Veterinary Medicine Series A 01/2002; 48(10):593-9. · 0.93 Impact Factor