The interrelation of Diabetes mellitus, obesity, and pyometra in the dog

American Journal of Veterinary Research (Impact Factor: 1.34). 02/1960; 21:120-7.
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    • "In the current study, only Golden retrievers, American Staffordshire terriers, Weimaraners and Rottweilers had a significantly higher prevalence. Of these dog breeds, Golden retrievers and Rottweilers have been previously reported to have a higher prevalence (Gibson et al., 2013; Smith, 2006; Egenvall et al., 2001; Niskanen and Thrusfield, 1998; Krook et al., 1960). "
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    ABSTRACT: ABSTRACT In this study, female canines referred with clinical signs consistent with pyometra were prospectively evaluated. Signalment, clinical signs, laboratory findings and surgical findings were compared between dogs with and without bacterial isolation based on aerobic techniques. Patients with positive bacterial isolation were placed in the pyometra group, whereas patients with negative bacterial isolation were grouped as mucometra. A total of 140 dogs (118 with pyometra and 22 with mucometra) met the inclusion criteria. Prereferral antibiotic administration was associated with a prolonged duration of clinical signs in the patients of the pyometra group (12 ± 2 days versus 7 ± 1 days; P=0.006). In the pyo-metra patients, clinical signs, like pyrexia, anorexia and discomfort on abdominal palpation, were observed more commonly than in the mucometra group. The total leukocyte count was the only parameter that differed significantly between the two groups (P=0.01). Although no difference in color and consistency of the uterine fluid was noted, the uteri of the pyometra group were heavier (851.80 ± 800.30 g compared to 263.50 ± 297.10 g). E. coli was the most commonly isolated bacterium (92/123). SAMENVATTING In deze studie werden vrouwelijke honden met klinische klachten verenigbaar met pyometra prospectief geëvalueerd. Het signalement, de klinische symptomen, laboratoriumresultaten en chirur-gische bevindingen werden vergeleken tussen honden met en zonder bacteriële isolatie op basis van aërobe technieken. Patiënten met een positieve bacteriële isolatie werden in de pyometragroep ge-klasseerd, terwijl patiënten met een negatieve bacteriële isolatie als honden met mucometra werden gegroepeerd. Honderdveertig honden (118 met pyometra en 22 met mucometra) voldeden aan de in-clusiecriteria. De toediening van een antibioticum vooraleer door te verwijzen was geassocieerd met verlengde klinische symptomen bij de patiënten van de pyometragroep (12 ± 2 dagen versus 7 ± 1 dagen; P = 0,006). Bij de pyometrapatiënten werden klinische symptomen, zoals koorts, anorexia en ongemak bij abdominale palpatie vaker waargenomen dan bij de mucometrapatiënten. Het totale aantal leukocyten was de enige parameter die significant verschilde (P=0,01). Hoewel er tussen de twee groepen geen verschil in kleur en consistentie van de baarmoedervloeistof werd opgemerkt, was de baarmoeder van de honden met pyometra zwaarder dan bij de honden met mucometra (851,80 ± 800,30 g versus 263,50 ± 297,10 g). E. coli was de vaakst geïsoleerde bacterie (92/123).
    Vlaams Diergeneeskundig Tijdschrift 09/2015; 84(4):188-196. · 0.42 Impact Factor
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    • "A genetic predisposition for pyometra has not been demonstrated, however, a number of studies have described over-representation within certain breeds, including rottweiler, golden retriever and Cavalier King Charles spaniel (Krook and others 1960, Niskanen and Thrusfield 1998, Egenvall and others 2001). Other breeds which have inconsistently been described as being over-represented include Saint Bernard, bernese mountain dog, rough collie, miniature schnauzer, great Dane, chow chow, pointer, Irish terrier and French bull dog (Krook and others 1960, Ewald 1961,Niskanen and Thrusfield 1998, Egenvall and others 2001). On the other hand, dachshunds have repeatedly been reported to have decreased incidence of pyometra (Krook and others 1960, Ewald 1961, Niskanen and Thrusfield 1998, Egenvall and others 2001). "
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    ABSTRACT: A retrospective cross-sectional study was used to analyse pyometra cases at five RSPCA Animal Hospitals across the UK from 2006 to 2011. A total of 1728 cases of pyometra were recovered from a female dog outpatient caseload of 78,469 animals, giving a total prevalence of 2.2 per cent over the study period. There was an annual increase in the incidence of pyometra within the population, while elective ovariohysterectomy caseload has declined. There were variations in breed and age at presentation. Bullmastiffs (P<0.0001), golden retrievers (P=0.001) and dogue de Bordeaux (P=0.008) were over-represented in the pyometra population when compared with the female dog outpatient caseload. Mean age at presentation was 7.7 years. Some breeds presented at a significantly lower age, including dogue de Bordeaux (mean age 3.3 years) and bullmastiffs (mean age 5.4 years), while others presented as older dogs, including Yorkshire terriers (mean age 9.4 years) and border collies (mean age 10.3 years). Surgical mortality rate at the Greater Manchester Animal Hospital was 3.2 per cent. Pyometra is of significant welfare concern, and also has cost implications, particularly in charity practice. These results serve to highlight this condition so that future change in charity practice caseload can be anticipated and strategies can be directed to improve animal welfare.
    10/2013; 173(16). DOI:10.1136/vr.101514
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    • "Since the 1950s, development of diabetes shortly after estrus has been well recognized in bitches and ovariohysterectomy (OHE) has been recommended as radical treatment of CDM (Campbell, 1958; Wilkinson , 1960). In the 1960s, Krook et al. (1960) first correlated CDM with pyometra, another typical condition associated with diestrus (Noakes et al., 2001) characterized by purulent fluid collection within the uterus with variable amounts of inflammatory cells in the uterine wall, that may or may not be preceded by cystic endometrial hyperplasia (Feldman and Nelson, 2004). Although insulin resistance mediated by progesterone is well characterized (Scaramal et al., 1997; Connolly et al., 2004; Batista et al., 2005), there is a paucity of case reports correlating CDM with diestrus, and mainly on its remission after spaying (Fall et al., 2008, 2010). "
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    ABSTRACT: Canine diabetes mellitus (CDM) remission is a rare event that is possible after the resolution of insulin resistance conditions, especially those related to the estrus cycle. A retrospective study was carried out at the Division of Veterinary Endocrinology from 2006 to 2011 to assess CDM remission rates after the resolution of problems associated with ovarian activity. Out of 117 female dogs diagnosed with CDM, six diabetes remission cases were identified and described after resolution of diestrus (1), or after ovariohysterectomy for pregnancy (1), ovarian remnant syndrome (1), and pyometra (3), even after initial presentation in severe diabetic ketosis or long after diagnosis (ovariohysterectomy was performed from 3 to 81days after diagnosis, and diabetes resolution was achieved within 4-39days after gonadectomy). Several factors may lead to diabetes remission. However, in these cases, ovariohysterectomy was crucial for the restoration of normal blood glucose levels, suggesting that diabetic bitches be spayed independently of the length of time after diagnosis.
    Research in Veterinary Science 11/2012; 94(3). DOI:10.1016/j.rvsc.2012.10.008 · 1.41 Impact Factor
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