Repeated intradermal injection of MPS initiated a hair growth cycle in the pigmented rabbit. Hep. S. was the most active in the reaction, followed by ChS-B. A single injection of MPS applied as the insoluble protamine complexes also stimulated hair growth, again with Hep. S. the most active. These experiments suggest an essential role of a sulfated MPS in the normal hair growth cycle, as suggested previously from the correlation of metachromasia and hair growth.
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