Phospholipid-Based Signaling in Plants

Swammerdam Institute for Life Sciences, Department of Plant Physiology, University of Amsterdam, NL-1098 SM Amsterdam, The Netherlands.
Annual review of plant biology (Impact Factor: 23.3). 02/2003; 54(1):265-306. DOI: 10.1146/annurev.arplant.54.031902.134748
Source: PubMed


Phospholipids are emerging as novel second messengers in plant cells. They are rapidly formed in response to a variety of stimuli via the activation of lipid kinases or phospholipases. These lipid signals can activate enzymes or recruit proteins to membranes via distinct lipid-binding domains, where the local increase in concentration promotes interactions and downstream signaling. Here, the latest developments in phospholipid-based signaling are discussed, including the lipid kinases and phospholipases that are activated, the signals they produce, the domains that bind them, the downstream targets that contain them and the processes they control.

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Available from: Harold J G Meijer, Oct 07, 2015
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    • "This is of particular interest, as these major structural phospholipids are substrates for phospholipases. Phospholipases and phospholipid-derived molecules are crucial elements in stress response mediation, particularly via the activation of the phospholipase A (PLA), phospholipase D (PLD), or phospholipase C (PLC) and diacylglycerol kinase (DAGK) pathways (Munnik and Testerink, 2009; Meijer and Munnik, 2003). In animals, in vitro exposure of epithelial cells to O 3 resulted in dose-dependent increases in phospholipase A2, phospholipase C and phospholipase D activity (Salgo et al., 1994; Kafoury et al.,1998). "
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    ABSTRACT: All along their life, plants and trees are exposed to various stresses, and particularly to abiotic ones. Ozone (O3) is one of the most important air pollutants, whose ground levels keep increasing as a result of climate change. High O3 concentrations deeply affect plants and cells, and impact worldwide crop and forest production. In plant leaves, O3 directly interferes with surface tissues or reaches mesophyll cells through stomata. In this case, O3 is almost immediately degraded into reactive oxygen species (ROS) in the apoplastic space of plant cells. For plants to acclimate to O3, the O3 stress signal has to be perceived at the cellular level and relayed to the nucleus to lead to cell reprogramming. The aim of this review is to focus on different O3-sensing localizations, i.e., epicuticular waxes, the cell wall and the plasma membrane, and to detail the different early signaling components related to these sites – in particular lipids, membrane proteins (G proteins, NADPH oxidases and ion channels) and MAP kinases. Finally, some interesting putative membrane-related O3 signaling components are presented as clues to be validated in future investigations.
    Environmental and Experimental Botany 06/2015; 114. DOI:10.1016/j.envexpbot.2014.11.012 · 3.36 Impact Factor
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    • "Moreover, CaM3 is supposed to be involved in the activation of HSFs shown by electrophoretic mobility-shift assays, real-time quantitative reverse transcriptionpolymerase chain reaction, and Western-blot analyses (Zhang et al., 2009). Membrane perturbations triggered by phospholipase D (PLD) and phosphatidylinositol phosphate kinase (PIPK), leading to the generation of lipid signals including phosphatidic acid (PA) and inositol-bis or trisphosphate (IP 2 , IP 3 ) also contribute to plasma membrane signals (Berridge and Irvine, 1984; Meijer and Munnik, 2003; Zhang et al., 2009a,b). Zheng et al. (2012) have shown a direct correlation between reduced phospholipase C9 activity and reduced IP3 amounts, leading to down-regulation of HSPs and reduced thermotolerance. "
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    ABSTRACT: Being sessile organisms, plants are constantly exposed to various kinds of environmental stimuli. To survive under unfavorable environmental conditions they have evolved strategies to allow a balance between growth, reproduction and survival. In this review article, we first focus on two major abiotic stress factors, drought and heat, and briefly summarize the current knowledge on signal transduction pathways involved in plant responses to these stresses. In nature it is unlikely that plants are exposed to abiotic or biotic stresses in isolation. Hence, multiple stress situations are more likely to occur including heat, drought, salinity and pathogen attack. Since in many cases stress responses are antagonistic, predictions of molecular responses to multiple stresses based on single stress data is difficult or even impossible. Only recently, researchers started to study multiple-stress interactions and discovered for instance that plant responses to a combination of heat and drought differ from those to both single stresses. Moreover, abiotic stress applications are likely to influence plant-pathogen interactions and vice versa. Here, we discuss various aspects of multiple stress applications published within the last few years and pronounce the importance to study biotic and abiotic stress combinations in order to predict plant responses to future climate changes.
    Environmental and Experimental Botany 06/2015; 114. DOI:10.1016/j.envexpbot.2014.06.020 · 3.36 Impact Factor
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    • "Intriguingly, a signalling role of DAG in plant cells is not obvious. Meijer and Munnik (2003) showed that DAG in plant cells is rapidly phosphorylated by DAG kinase to phosphatidic acid (PA), which plays active roles in plant signalling processes. However, data showing DAG as a signalling platform in plants are emerging (Helling et al., 2006; Pejchar et al., 2010; Pejchar et al., 2015). "
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    ABSTRACT: Successful establishment and maintenance of cell polarity is crucial for many aspects of plant development, cellular morphogenesis, response to pathogen attack, and reproduction. Polar cell growth depends on integrating membrane and cell-wall dynamics with signal transduction pathways, changes in ion membrane transport, and regulation of vectorial vesicle trafficking and the dynamic actin cytoskeleton. In this review, we address the critical importance of protein-membrane crosstalk in the determination of plant cell polarity and summarize the role of membrane lipids, particularly minor acidic phospholipids, in regulation of the membrane traffic. We focus on the protein-membrane interface dynamics and discuss the current state of knowledge on three partially overlapping levels of descriptions. Finally, due to their multiscale and interdisciplinary nature, we stress the crucial importance of combining different strategies ranging from microscopic methods to computational modelling in protein-membrane studies. © The Author 2015. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email:
    Journal of Experimental Botany 02/2015; 66(6). DOI:10.1093/jxb/erv052 · 5.53 Impact Factor
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