Article

Cyclin D1 and molecular chaperones: implications for tumorigenesis.

Howard Hughes Medical Institute, Whitehead Institute/MIT Center for Genome Research, Cambridge, Massachusetts, USA.
Cell cycle (Georgetown, Tex.) (impact factor: 5.36). 2(6):525-7. pp.525-7
Source: PubMed

ABSTRACT We recently investigated the mechanisms of cyclin D1 action in human cancer using global analyses of gene expression. With an experimentally-determined expression signature for cyclin D1 overexpression, gene expression data from human tumors, and a novel data-mining method, we were able to reveal a previously unappreciated and apparently predominant functional interdependency between cyclin D1 and C/EBPbeta. Many of the genes we found to be affected by cyclin D1 overexpression are recognized as molecular chaperones or their regulators. Might this provide insights to the role of the cyclin D1-C/EBPbeta axis in carcinogenesis?

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Keywords

carcinogenesis
 
cyclin D1
 
cyclin D1 action
 
cyclin D1 overexpression
 
cyclin D1-C/EBPbeta axis
 
gene expression
 
gene expression data
 
genes
 
global analyses
 
molecular chaperones
 
predominant functional interdependency
 
provide insights
 
unappreciated
 

Justin Lamb