Successful Outcome of Disseminated Fusarium Infection with Skin Localization Treated with Voriconazole and Amphotericin B-Lipid Complex in a Patient with Acute Leukemia

Parasitologie-Mycologie, Faculté de Médecine, CHRU de Lille, Lille, France.
Journal of Clinical Microbiology (Impact Factor: 3.99). 11/2003; 41(10):4898-900. DOI: 10.1128/JCM.41.10.4898-4900.2003
Source: PubMed


A disseminated Fusarium oxysporum infection with skin localization was diagnosed in a woman with a relapse of B-acute leukemia during induction chemotherapy.
The infection was refractory to amphotericin B-lipid complex alone but responded successfully when voriconazole was added.

Download full-text


Available from: Serge Alfandari,
18 Reads
  • Source
    • "To our knowledge, this is the first case reported in the literature of ecthyma gangrenosum-like lesions with simultaneous Pseudomonas sepsis and disseminated fusariosis. In the management of fusariosis, conventional or liposomal Amp B may be used singly; successful results were achieved also by combining it with voriconazole or posaconazole [8,9,10]. In the present case, voriconazole was combined with caspofungin instead of liposomal Amp B and complete response to treatment was achieved, with total resolution of cranial and pulmonary lesions. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Fusarium spp. is an opportunistic mold that causes disseminated infections in immunocompromised patients. It is important to make a definite diagnosis because of high mortality rates. We present the case of a 27-year-old pregnant woman diagnosed with acute myeloid leukemia with a prolonged febrile neutropenic period. She developed ecthyma gangrenosum-like lesions and simultaneously had Pseudomonas bacteremia and disseminated fusariosis. Histopathological and microbiological features of skin lesions had a critical role in differential diagnosis. Ecthyma gangrenosum-like lesions due to disseminated fusariosis might be easily misdiagnosed as lesions associated with Pseudomonas unless tissue cultures and histopathological examinations are performed. Conflict of interest:None declared.
    Turkish Journal of Haematology 09/2013; 30(3):321-4. DOI:10.4274/Tjh.2012.0030 · 0.36 Impact Factor

  • Drugs 01/2007; 67(2). DOI:10.2165/00003495-200767020-00009 · 4.34 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Fungal infections caused by Fusarium in the immunocompromised host are highly resistant to all antifungal agents. Fusarium endocarditis is a rare and usually fatal disease. We report an immunocompromised child who survived Fusarium solani endocarditis despite the in vitro resistance of the organism to all available antifungal agents.
    The Pediatric Infectious Disease Journal 12/2004; 23(11):1059-61. DOI:10.1097/01.inf.0000143649.90952.41 · 2.72 Impact Factor
Show more