Relations Between Continuous Performance Test Performance Measures and ADHD Behaviors
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27705, USA.Journal of Abnormal Child Psychology (Impact Factor: 3.48). 11/2003; 31(5):543-54. DOI: 10.1023/A:1025405216339
The Conners' Continuous Performance Test (CPT) is a neuropsychological task that has repeatedly been shown to differentiate ADHD from normal groups. Several variables may be derived from the Conners' CPT including errors of omission and commission, mean hit reaction time(RT), mean hit RT standard error, d', and beta. What each CPT parameter actually assesses has largely been based upon clinical assumptions and the face validity of each measure (e.g., omission errors measure inattention, commission errors measure impulsivity). This study attempts to examine relations between various CPT variables and phenotypic behaviors so as to better understand the various CPT variables. An epidemiological sample of 817 children was administered the Conners' CPT. Diagnostic interviews were conducted with parents to determine ADHD symptom profiles for all children. Children diagnosed with ADHD had more variable RTs, made more errors of commission and omission, and demonstrated poorer perceptual sensitivity than nondiagnosed children. Regarding specific symptoms, generalized estimating equations (GEE) and ANCOVAs were conducted to determine specific relationships between the 18 DSM-IV ADHD symptoms and 6 CPT parameters. CPT performance measures demonstrated significant relationships to ADHD symptoms but did not demonstrate symptom domain specificity according to a priori assumptions. Overall performance on the two signal detection measures, d' and beta, was highly related to all ADHD symptoms across symptom domains. Further, increased variability in RTs over time was related to most ADHD symptoms. Finally, it appears that at least 1 CPT variable, mean hit RT, is minimally related to ADHD symptoms as a whole, but does demonstrate some specificity in its link with symptoms of hyperactivity.
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- "Moreover, disrupted impulse control has been observed in psychiatric disorders such as attention-deficit/hyperactivity disorder (Epstein et al., 2003, 2006), antisocial or borderline personality disorders (Dougherty et al., 1999; Swann et al., 2009a), and bipolar disorder (Swann et al., 2003, 2009b). Thus, elucidating the neural basis of impulse control would be an important contribution to modern society. "
ABSTRACT: Poor impulse control is a debilitating condition observed in various psychiatric disorders and could be a risk factor for drug addiction, criminal involvement, and suicide. The rat infralimbic cortex (IL), located in the ventral portion of the medial prefrontal cortex, has been implicated in impulse control. To elucidate the neurophysiological basis of impulse control, we recorded single unit activity in the IL of a rat performing a 3-choiceserial reaction time task (3-CSRTT) and 2-choice task (2-CT), which are animal models for impulsivity. The inactivation of IL neuronal activity with an injection of muscimol (0.1μg /side) disrupted impulse control in the 3-CSRTT. More than 60% (38/56) of isolated IL units were linked to impulse control, while approximately 30% of all units were linked to attentional function in the 3-CSRTT. To avoid confounding motor-related units with the impulse control-related units, we further conducted the 2-CT in which the animals' motor activities were restricted during recording window. More than 30% (14/44) of recorded IL units were linked to impulse control in the 2-CT. Several types of impulse control-related units were identified. Only 16% of all units were compatible with the results of the muscimol experiment, which showed a transient decline in the firing rate immediately before the release of behavioral inhibition. This is the first study to elucidate the neurophysiological basis of impulse control in the IL and to propose that IL neurons control impulsive actions in a more complex manner than previously considered.Behavioural brain research 09/2015; DOI:10.1016/j.bbr.2015.08.025 · 3.03 Impact Factor
- "Four types of responses were also recorded: hit (a target appeared and the participant responded), omission (a target appeared and the participant failed to respond), correct inhibition (a distractor appeared and the participant did not respond) and false alarm (a distractor appeared and the participant responded). Omissions reflect inattention where as false alarms reflect hyperactivity–impulsivity (Barkley, 1991; Epstein et al., 2003). These two types of errors were calculated in percentage according to the total number of targets or distractors (omission = number of omissions/number of targets × 100; false alarm = number of false alarms/number of distractors × 100). "
Article: Neurotoxicology and Teratology[Show abstract] [Hide abstract]
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- "Another limitation of the current study is that parent-report measures were used instead of performance-based tasks to assess attention problems. Studies have shown that both parent and teacher ratings of attention problems tend to show small and somewhat inconsistent correlations with performance-based indices of attention and executive functioning (Epstein et al. 2003; Toplak et al. 2013 "
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