Limb salvage in bone sarcomas in patients younger than age 10: a 20-year experience.

Department of Orthopedic, University of Navarra, Pamplona, Spain.
Journal of Pediatric Orthopaedics (Impact Factor: 1.43). 01/2003; 23(6):753-62. DOI: 10.1097/00004694-200311000-00013
Source: PubMed

ABSTRACT The authors present their experience over the last 20 years in limb salvage procedures of a consecutive series of 40 children under 10 years of age (range 2-10 years) with bone sarcomas. Nineteen were osteogenic sarcomas and 21 were Ewing sarcomas. Only one case, located in the distal phalanx of the toe, was treated by straightforward amputation. Intercalary allografts and Canadell's technique were used to preserve joints whenever possible, and prosthesis or osteoarticular allografts were used when the joint surface was involved. Survival rate in this series was 75%. There were four local recurrences. At the last follow-up (mean 11.2 years, range 5-19 years postop), 90% of the patients preserved their limbs. Eighty percent of the authors' results were excellent or good according to the Musculoskeletal Tumor Society Scale. Limb salvage is a real possibility even in young children with bone sarcomas. The age of the patient itself is not a contraindication for limb salvage.

  • [Show abstract] [Hide abstract]
    ABSTRACT: Sarcomas of bone have a number of distinguishing features that set them apart from primary cancers of many other organ systems. First, they are extremely rare in comparison with other types of cancer, a fact that has impeded the ability of treatment in this field to evolve rapidly in an evidence-based manner because of the small numbers of patients available for studies. Progress in this field has been possible only with multicenter and oncology group trials that can provide sufficient numbers of patients for study. Even so, clinical trials are generally limited to prospective case series at best, and much of the literature is based on retrospective case series. True controlled randomized prospective trials are extremely rare. Nevertheless, a number of clinically useful observations defining the behavior of these tumors and their responses to treatments have derived from the analyses of the numerous case series that have been published, and these results and the associated levels of evidence are reviewed here.
    12/2005: pages 1034-1047;
  • Pediatric PET Imaging, Edited by Charron M, 05/2006: pages 267-301; Springer., ISBN: 978-0-387-28836-9
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The feasibility of distal femur epiphysis preservation through epiphyseal distraction by external fixator in childhood osteosarcoma was explored.
    World Journal of Surgical Oncology 08/2014; 12(1):251. DOI:10.1186/1477-7819-12-251 · 1.20 Impact Factor


Available from
May 20, 2014