Fatigue and its association with sociodemographic variables among multiple sclerosis patients.
ABSTRACT To explore the relationship between fatigue, sociodemographic and clinical variables in a population of patients with multiple sclerosis (MS).
There is a need to identify empirical relationships with possible antecedents of fatigue among patients with MS.
A mailed questionnaire designed to survey sociodemographic variables and the Fatigue Severity Scale (FSS) was mailed to 502 individuals from the population of patients with definite MS in the city of Oslo. A total of 368 (73%) responded. Clinical data were collected from the Oslo City MS-Registry.
The prevalence of fatigue in this population was 60.1%. The FSS score showed a negative correlation with education (r = -0.15, P < 0.01) and a positive correlation with age (r = 0.20, P < 0.001) and time since disease onset (r = 0.11, P < 0.05). When controlled for gender, level of education and time since disease onset, the data showed a positive relationship between fatigue and age (P < 0.001) among patients with primary progressive (PP) disease. This relationship between age and fatigue was not found among patients with relapsing-remitting/secondary progressive (RR/SP) disease.
The negative relationship between level of formal education (FE) and fatigue among individuals with RR/SP disease suggests that behavioral factors may be among the antecedents of fatigue in this patient group. In contrast to normative data from the general population, our findings revealed no differences in fatigue related to gender Thus, this study supports the hypothesis that there are disease-specific antecedents of fatigue among patients with MS.
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ABSTRACT: Background Depression is the most common co-morbidity for people with Multiple Sclerosis (MS); irrespective of disease severity, depression has the greatest impact on quality of life. An emerging paradigm in the treatment of depression is lifestyle medicine. There is significant potential to prevent and treat depression through modification of lifestyle risk factors for people with MS. This study sought to understand the association between lifestyle risk factors, medication and depression risk through the analysis of self-reported data from a large international sample of people with MS.Methods This cross-sectional analysis recruited a total of 2459 participants via Web 2.0 platforms. Survey data included socio-demographics; a range of lifestyle risk factors; medication; disease variables and depression risk using the Patient Health Questionnaire-2 (PHQ-2).ResultsIn total approximately one fifth (19.3%) of our sample screened positive for depression (PHQ-2 score ¿3). Several demographic factors were significantly associated with this depression risk in bivariate analysis. Regression analyses showed that poor diet, low levels of exercise, obesity, smoking, marked social isolation and taking interferon were associated with greater depression risk. Participants who supplemented with omega 3s, particularly flaxseed oil, had frequent fish consumption, supplemented with vitamin D, meditated, and had moderate alcohol consumption had significantly reduced depression risk.Conclusions This study demonstrates a significant association between modifiable lifestyle factors and depression risk. Planned longitudinal follow up may clarify causality. Clinicians and people with MS should be aware of the wide range of modifiable lifestyle factors that may reduce depression risk as part of a comprehensive secondary and tertiary preventive medical approach to managing MS.BMC Psychiatry 12/2014; 14(1):327. · 2.24 Impact Factor
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ABSTRACT: Introduction: Multiple Sclerosis (M.S) is a chronic disease afflicting the nervous system and destroying the myelin sheath of the central nervous system (brain and spinal cord). Fatigue is the most common and weakening symptom of M.S. The present study aims at investigating the effects of 8 weeks of aquatic aerobic training on fatigue severity in M.S patients. Material and Methods: The study is quasi-experimental and the findings are of practical value. From 100 female M.S patients, 40 participants aged between 20 to 50 years, with illness severity of 6 to 1 and mean illness duration of 4±1 years were selected to take part in this study. They were randomly assigned into two groups: a control group and an experimental group, each with 20 participants. . The training program was implemented on the experimental group for 8 weeks, 3 sessions per week, at the intensity of 50-60% maximum heart rate. Descriptive statistics, dependent and independent t tests were run to analyze the data. Results: The posttest mean fatigue severity in the experimental and control groups were 2.94±0.91 and 4.22 0.96 respectively. There was no significant difference between the mean fatigue severity in the control and experimental groups (P=0.001). Discussion and Conclusion: Aquatic aerobic training may reduce fatigue severity in the M.S patients. Based on the present finding, the therapists may use aquatic aerobic training as a supplementary treatment beside medications for the M.S patients.
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ABSTRACT: The purpose of the study was to examine fatigue interference with daily living in patients with inflammatory bowel disease (IBD) and to explore relationships between severe fatigue interference and socio-demographic and clinical variables, including use of complementary and alternative medicine (CAM). Data were collected using self-report questionnaires from adult IBD outpatients. Fatigue interference was assessed with the 5-item Fatigue Severity Scale, and scores ≥5 were defined as severe fatigue interference. CAM use was assessed with the International CAM Questionnaire. Multivariate logistic regression analysis was used to examine associations between severe fatigue interference and socio-demographic factors, clinical factors, and CAM use. In total, 428 patients had evaluable questionnaires (response rate 93 %). Severe fatigue interference was reported by 39 % of the total sample. Patients with Crohn's disease (CD) (n = 238) were more likely than patients with ulcerative colitis (UC) (n = 190) to report severe fatigue interference (43 and 33 %, respectively, p = 0.003). In addition, patients reporting severe fatigue interference were more likely to have active disease than patients without severe fatigue interference (p < 0.001 for both diagnoses). Patients with inactive disease had scores comparable to the general population. Factors independently associated with severe fatigue interference in UC included disease activity and CAM use, while in CD they included disease activity and current smoking. Severe fatigue interference is common among IBD patients with active disease. Among patients with UC, but not CD, CAM use was associated with severe fatigue interference. The relationship between fatigue interference and personal factors should be considered further in subsequent studies.Quality of Life Research 08/2013; · 2.86 Impact Factor