Continuous apomorphine infusion and neuropsychiatric disorders: a controlled study in patients with advanced Parkinson's disease

Department of Neuroscience, University of Messina, Via Consolare Valeria, Messina, Italy.
Neurological Sciences (Impact Factor: 1.5). 11/2003; 24(3):174-5. DOI: 10.1007/s10072-003-0116-0
Source: PubMed

ABSTRACT The aim of this study was to assess whether patients with Parkinson's disease (PD) develop cognitive and psychiatric complications more frequently during prolonged therapy with continuous apomorphine infusion compared with standard oral treatment. Thirty consecutive PD patients with severe motor fluctuations were included in the study. Twelve patients accepted the treatment with subcutaneous continuous apomorphine infusion, while the remaining 18 preferred to continue with oral dopaminergic therapy. The two groups were evaluated with neuropsychological, psychiatric, and motor tests at baseline and after 1 year. The off daily duration and the levodopa dosage were significantly reduced in infused patients. The neuropsychiatric assessment did not change in both groups compared with baseline, except for a significant improvement of mood in the apomorphine group.

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Available from: Giorgio Basile, Jul 28, 2015
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    • "Despite these side-effects, the treatment has been demonstrated to give a lasting improvement of dyskinesias and to reduce off-time signifi cantly (Colzi et al 1998; Stocchi et al 2001; Kanovsky et al 2002). In studies evaluating long-term treatment, no worsening of neuropsychiatric parameters has been described (Di Rosa et al 2003). Dosage of levodopa can be considerably reduced without loss of symptom control but some levodopa usually must be maintained (Colzi et al 1998; Stocchi et al 2001). "
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