This article is intended to explore how minority status and cultural factors affect the participation of subjects in clinical psychopharmacology research.
A literature review was performed using key words "clinical psychopharmacology trials", "psychiatric ethics" and "minority groups". Major goals of this review were to examine current knowledge base and identify existing gaps in this fairly new area of psychiatric research.
We found extremely few papers addressing the issue directly. Most references to minority groups were made peripherally, and many of these were extrapolated to psychiatric patients from work done on medical populations. We found no empirical studies done in psychiatric populations.
Systematic, well-designed research studies are needed to elucidate how culture, race and ethnicity impact on such issues as accrual, retention, informed consent and safeguards against the potential exploitation of minority research subjects. On the basis of the literature review and our personal experience doing clinical research with minority patients, we provide several recommendations and specific suggestions to clinical researchers who include minority patients in their clinical trials.
"Instead, research conducted in the west is extrapolated to all other parts of the world. The resultant use of medications without adequate clinical trials targeting specific ethnic and minority populations leaves them at risk for possible idiosyncratic side effects or inappropriate dosing (Miskimen et al., 2003). "
[Show abstract][Hide abstract] ABSTRACT: In clinical studies and cross-national surveys, cultural or ethnic factors have been found to be significant determinants in patients' responses to psychotropic medication. Dosage requirements and the potential for toxic reactions might differ amongst racial and ethnic groups. In this paper, the authors review the relevant literature and examine pharmacodynamic, pharmacokinetic and cultural-psychological factors, all of which could be responsible for such ethnic variations.
Culture Medicine and Psychiatry 05/1986; 10(2):151-165. DOI:10.1007/BF00156581 · 1.29 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: This tutorial addresses the following questions:¿ why do formal verification?¿ who is doing it today?¿ what are they doing?¿ how are they doing it?¿ what about the future?
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