Article

The evaluation of anxiety and salivary cortisol levels in patients with oral lichen planus.

Department of Oral Medicine and Oral Surgery, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
Oral Diseases (impact factor: 2.49). 12/2003; 9(6):298-301. pp.298-301
Source: PubMed

ABSTRACT The aim of this study was to determine any association between anxiety and salivary cortisol levels in oral lichen planus (OLP) patients by the case-control method. DESIGN RELEVANT: Forty patients with OLP were evaluated. The OLP diagnosis was established through a composite of accepted clinical and histopathological characteristics. Forty patients from the register of patients who obtained general dental care were selected as controls.
The saliva samples collected between 9:00 and 9:15 am were analysed for the level of cortisol with Cortisol EIA that used competitive enzyme-linked immunosorbent assay method. Trait and state anxiety levels of 80 patients were measured using the Spielberger's State-Trait Anxiety Inventory.
The mean level of cortisol from 40 saliva samples in study group was 1.46 and 0.93 microg dl(-1) in 40 controls (P=0.001). The mean level for state anxiety in the study group were 48.85 and 39.45 in control group (P=0.001). Trait anxiety levels in study group were 49.77 and 38.51 in control group (P=0.001). We found that salivary cortisol, state and trait anxiety levels in OLP group were significantly higher than in the control group.
Because of the fact that the level of anxiety and salivary cortisol of OLP patients were high, our findings concluded that this disease is closely related with stress. Thus besides traditional treatment of OLP patients, our findings suggest that psychological support is also needed.

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Keywords

40 controls
 
80 patients
 
case-control method
 
control group
 
Cortisol EIA
 
general dental care
 
mean level
 
OLP diagnosis
 
OLP group
 
OLP patients
 
psychological support
 
salivary cortisol
 
salivary cortisol levels
 
Spielberger's State-Trait Anxiety Inventory
 
state anxiety
 
state anxiety levels
 
study group
 
traditional treatment
 
trait anxiety levels
 
used competitive enzyme-linked immunosorbent assay method