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Three cases of idiopathic thrombocytopenic purpura showing an increase in the platelet count following clarithromycin treatment

Department of Internal Medicine, Hokkaido Social Insurance Hospital.
[Rinshō ketsueki] The Japanese journal of clinical hematology 11/2003; 44(10):1044-6.
Source: PubMed

ABSTRACT Macrolides have immuno-modulatory effects as well as anti-bacterial effects. We successfully treated three idiopathic thrombocytopenic purpura (ITP) patients with clarithromycin (CAM). Case 1: A 69-year-old male ITP patient was treated with CAM at a dose of 400 mg/day. His platelet count increased from 5.6 x 10(4)/microliter to 10.1 x 10(4)/microliter. Case 2: A 72-year-old male ITP patient was treated with CAM at the same dose. The platelet count increased from 1.3 x 10(4)/microliter to 12.3 x 10(4)/microliter. Case 3: A 68-year-old female ITP patient was treated with CAM at the same dose. The platelet count increased from 2.3 x 10(4)/microliter to 13 x 10(4)/microliter. These facts suggest that CAM is useful in the treatment of ITP.

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    • "In a previous work, the authors have already reported 3 cases of idiopathic thrombocytopenic purpura (ITP), also known as primary immune thrombocytopenia, which show increased platelet counts following clarithromycin treatment, irrespective of H. pylori infection status [56]. The authors attributed this therapeutic success of macrolides in treating cases of ITP to the immunomodulatory effects of macrolides. "
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    • "pylori) [1-3]. We have already reported 3 cases of idiopathic thrombocytic purpura (ITP), also known as primary immune thrombocytopenia, which show increased platelet counts following clarithromycin (CAM) treatment, irrespective of H. pylori infection status [4]. ITP is an autoimmune disease induced by autoantibodies against platelets. "
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