Neurological findings in a case of coma secondary to Datura stramonium poisoning.
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ABSTRACT: A spontaneous intoxication in 34 horses after intake of freshly harvested ensiled maize, accidentally contaminated with young Datura stramonium plants was followed. In a 7-day study, the full clinical status was monitored and this included among others the following: body (rectal) temperature, respiratory and heart rates, colour and humidity of visible mucosae, changes in pupil size, appetite, thirst, general behaviour, locomotion, sensory perceptions, urination, defecation. Results manifesting in these clinical parameters were a generalised intoxication associated with mild hyperthermia, tachycardia, polypnoea, dyspnoea and shallow breathing, mydriasis, dry oral, rectal, vaginal and nasal mucosae, acute gastric dilatation and severe intestinal gas accumulation, anorexia to complete refusal of feed, decreased or absent thirst, absence of defecation and urination. On treatment, the clinical indices were normalized between days 2 and 5. In dead horses (n=2), necropsies and pathological studies were performed. They revealed a toxic liver dystrophy, cardiac lesions and substantial dystrophic and necrotic processes in kidneys. The observed clinical signs, the pathomorphological changes and the applied therapy could be used in the diagnosis, differential diagnosis, prognosis and treatment of Jimson weed intoxication.Trakia Journal of Sciences 56 Trakia Journal of Sciences. 01/2006; 4(4):56-63.
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