Article

Motor effects of amphetamine in rats pretreated with either dizocilpine or phencyclidine.

Laboratory of Electrophysiology and Behavior, Department of Neurobiology and Immunology, Institute for Biological Research, 29 Novembra 142, 11060 Belgrade, Yugoslavia.
Behavioural Brain Research (impact factor: 3.42). 01/2004; 147(1-2):211-5.
Source: PubMed

ABSTRACT The aim of the present study was to examine motor effects of amphetamine (AMPH) in rats pretreated with either dizocilpine (MK-801) or phencyclidine (PCP), and to estimate possible differences in these effects. Our results showed that AMPH increases the duration of motor effects of PCP, while it does not change motor effects of MK-801. These findings may reflect different mechanisms of action of MK-801 and PCP, as well as selective influence of AMPH on metabolism of these drugs.

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Keywords

AMPH
 
AMPH increases
 
amphetamine
 
different mechanisms
 
estimate possible differences
 
motor effects
 
phencyclidine
 
rats pretreated
 
selective influence
 

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