Article

[Advances in researches on lactate dehydrogenase-C4 isozyme].

Center for Laboratory Medicine, Fuzhou General Hospital, PLA, Fuzhou, Fujian 350025, China.
Zhonghua nan ke xue = National journal of andrology 12/2003; 9(8):607-10. pp.607-10
Source: PubMed

ABSTRACT Lactate dehydrogenase-C4 isozyme has been widely studied as the sperm-specific antigen in the research of the contraceptive vaccine. Developmental and testis-specific expression of the LDH-C gene requires mechanisms for activation in germ cells and repression in somatic cells. LDH-C promoter, several transcription factors and methylation of CpG dinucleotides have been proved of governing action on LDH-C gene transcription. The strategy is to induce antibodies in the female reproductive tract against LDH-C antigens at a sufficient level to block fertilization. Chemically modified LDH-C4 offers a potential application in the induction of infertility of homologous species in marked contrast to native LDH-C4. In addition, advances are being made in researches on the male contraceptive vaccine and synthetic peptide immunocontraceptive.

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Keywords

activation
 
contraceptive vaccine
 
CpG dinucleotides
 
Developmental
 
female reproductive tract
 
germ cells
 
homologous species
 
induction
 
infertility
 
Lactate dehydrogenase-C4 isozyme
 
LDH-C gene transcription
 
LDH-C promoter
 
male contraceptive vaccine
 
potential application
 
somatic cells
 
sufficient level
 
synthetic peptide immunocontraceptive
 
transcription factors