Etiology of and risk factors for cerebral infarction in young adults in western Norway: a population-based case-control study.
ABSTRACT We sought to study the etiology of and risk factors for cerebral infarction in young adults in Hordaland County, Norway. All patients aged 15-49 years living in Hordaland County with a first-ever cerebral infarction during 1988-97 were included. Etiology was analyzed in subgroups defined by sex, age (<40 years versus >/=40 years), circulation territory (anterior versus posterior circulation) and short-term functional outcome [modified Rankin score (mRS) </= 2 versus mRS > 2]. A questionnaire was used to evaluate possible risk factors amongst the patients compared with an age- and sex-matched control group. The distribution of etiology was significantly different in all subgroups. Atherosclerosis was frequent amongst men (22.8% vs. 4.2%) and patients >/= 40 years (20.8% vs. 2.7%). All patients with microangiopathy had favorable short-term outcome. Significant risk factors were smoking more than 15 cigarettes per day (P < 0.001), hypertension (P = 0.001), and myocardial infarction (P = 0.035). Modifiable risk factors were frequent.
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ABSTRACT: To assess the frequency of females and males aged ≤ 30 years with cerebral infarction in two different time periods. All patients aged ≤ 30 years with arterial cerebral infarction in 1988-1997 and 2006-2010 admitted to Haukeland University Hospital in Bergen, Norway, were included. Risk factors and etiology were assessed. Between 1988 and 1997, 16 females and 7 males had cerebral infarction, whereas 0 females and 13 males had cerebral infarction in 2006-2010 (P = 0.0001). The incidence of cerebral infarction in females was significantly lower between 2006 and 2010 than between 1988 and 1997 (P = 0.007). Our findings suggest that the frequency of cerebral infarction among young females has dropped significantly during recent years.Vascular Health and Risk Management 01/2011; 7:81-4.