Antiparasitic activities of medicinal plants used in Ivory Coast

Muséum National d'Histoire Naturelle, Lutetia Parisorum, Île-de-France, France
Journal of Ethnopharmacology (Impact Factor: 2.94). 02/2004; 90(1):91-7. DOI: 10.1016/j.jep.2003.09.029
Source: PubMed

ABSTRACT During an ethnopharmacological survey of antiparasitic medicinal plants used in Ivory Coast, 17 plants were identified and collected. Polar, non-polar and alkaloidic extracts of various parts of these species were evaluated in vitro in an antiparasitic drug screening. Antimalarial, leishmanicidal, trypanocidal, antihelminthiasis and antiscabies activities were determined. Among the selected plants, Anogeissus leiocarpus and Terminalia glaucescens were strongly active against Plasmodium falciparum. Lawsonia inermis, selectively prescribed against trypanosomiasis shows interesting trypanocidal activities as did other 15 plants. Anthelmintic activities were found for 10 active species and 2 species (Uvaria afzelli and Monodora myristica) were actives against mites.

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    ABSTRACT: Lawsonia inermis, popularly known as Henna or Mehndi in the Oriental world, is an evergreen medium sized shrub of the Family Lythraceae. The leaf paste of this plant has been traditionally used for dying hair, skin and nails since antiquity. Besides cosmaceutical usages, the plant also harbours a well-documented folklore history for treating convulsion, jaundice and malignant ulcers. Phytochemical studies in henna plant have indicated the presence of several bioactive molecules like isoplumpagin, lupeol, 30-norlupan-3-ol-20-one, betuhennan, betuhennanic acid and n-tridecanoate phenolic glycosides, lawsoniaside, β-sitosterol and stigmasterol in leaves and roots. Lawsone (2-hydroxy-1,4-naphthoquinone), the red orange dye present in the henna leaf paste, is being used in modern pharmacopoeia as a starting molecule for the synthesis of clinically important anticancer drugs such as atovaquone, lapachol and dichloroallyl lawsone. Pharmacological prospection of L. inermis plant extracts in last two decades have indicated strong nootropic, CNS depressing, antimicrobial, antioxidant, wound healing, anti-inflammatory, antipyretic, analgesic, hepatoprotective, tuberculostatic, diuretic, hypoglycemic and antiparasitic actions. An attempt has been made in this review to accentuate a comprehensive literature up-date on pharmacological investigations carried out in L. inermis. To the best of our knowledge and belief this is the first compilation in this direction in Henna.
    Industrial Crops and Products 03/2015; 65. DOI:10.1016/j.indcrop.2014.11.025 · 3.21 Impact Factor
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    ABSTRACT: Abstract Ethnopharmacological relevance Most adults in West Africa treat acute febrile illnesses with local herbs, but the patterns of herbs used for malaria have not been recently described in Sierra Leone. Materials and methods We used a population-based cross-sectional approach to interview 810 randomly-sampled rural and urban adult residents of Bo, Sierra Leone, in December 2013 and January 2014 about their use of herbal remedies when they suspect they have malaria. Results In total, 55% of the participants reported taking one or more of seven herbs to treat symptoms of malaria. Among herb users, the most commonly used anti-malarial herbs were Moringa oleifera (moringa, 52%) and Sarcocephalus latifolius (yumbuyambay, 50%). The other herbs used included Senna siamea (shekutoure, 18%), Cassia sieberiana (gbangba, 18%), Uvaria afzelii (gone-botai, 14%), Morinda chrysorhiza (njasui, 14%), and Craterispermum laurinum (nyelleh, 7%). Combination herbal therapy was common, with 37% of herb users taking two or more herbs together when ill with suspected malaria. Conclusions Indigenous medical knowledge about herbal remedies and combinations of local herbs remains an integral part of malaria case management in Sierra Leone.
    Journal of Ethnopharmacology 03/2015; · 2.94 Impact Factor
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    ABSTRACT: Infections with helminths are still a big problem in many parts of the world. The majority of the people in West Africa treat such infections with medicinal plants related to the local traditional medicine. The present study aimed at identifying medicinal plants traditionally used for worm infections in the Ashanti region, Ghana. In vitro screening of selected extracts from plants on which scientific knowledge is limited was to be performed.
    Journal of Ethnopharmacology 10/2014; DOI:10.1016/j.jep.2014.10.029 · 2.94 Impact Factor


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May 16, 2014