Article

Systemic capsaicin for burning mouth syndrome: short-term results of a pilot study

Università degli Studi di Bari Aldo Moro, Bari, Apulia, Italy
Journal of Oral Pathology and Medicine (Impact Factor: 1.87). 03/2004; 33(2):111-4. DOI: 10.1111/j.1600-0714.2004.0194n.x
Source: PubMed

ABSTRACT Burning mouth syndrome (BMS) is a major diagnostic and therapeutic problem. Systemic and topical treatments (capsaicin, lidocaine, anti-histamines, sucralfate and benzydiamine) have been tried, but they appear to be inadequate. Topical capsaicin is bitter, may cause burning and has low therapeutic efficacy. We hypothesized that systemic administration of capsaicin could reduce the limitations of topical administration and have better therapeutic efficacy; this hypothesis was tested in a controlled trial.
Systemic oral capsaicin 0.25% was used for patients with BMS, recruited in our single centre. After the diagnosis of BMS, patients were dentally and medically examined. They were alternatively assigned to treatment with capsaicin or to a shape/smell/taste/color matched placebo. The severity of symptoms was scored at trial entry and 30 days thereafter by investigators who were unaware of the assigned intervention. The visual analogical scale (VAS) measure was used to score the severity of pain, and results for the treated and untreated groups were compared by Fisher's exact test. Analysis was performed by intention-to-treat. Statistical significance was considered for values of P < 0.05. Data are expressed as mean +/- SD.
Fifty patients were enrolled (25 assigned to systemic capsaicin and 25 to placebo). The VAS score was significantly lower in treated patients (5.84 +/- 1.17) as compared to the placebo-control group (6.24 +/- 0.96). The use of systemic capsaicin implied significant gastric toxicity (referred gastric pain) with eight cases (32%) documented in the treatment group as compared to zero cases (0%) in the placebo control group.
Systemic capsaicin is therapeutically effective for the short-term treatment of BMS but major gastrointestinal side-effects may threaten its large-scale, long-term use. This preliminary study suggests that more, adequately powered, randomized controlled trials are necessary and worthy to come to a definitive assessment of this matter.

0 Followers
 · 
114 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: BACKGROUND: Burning Mouth Syndrome (BMS) is a chronic disease characterized by absence of any lesions and burning of the oral mucosa associated to a sensation of dry mouth and/or taste alterations. The purpose of our study is to estimate signs and symptoms of Temporomandibular Disorders (TMD) in patients with BMS and to investigate for the existence of an association between BMS and TMD. MATERIALS AND METHODS: Forty-four BMS patients were enrolled; BMS subtype was established according to the classification of Lamey. After a gnathological evaluation, according to the protocol of the European Academy of Craniomandibular Disorders, patients were classified by RDC/TMD criteria. The data were compared and analyzed using a chi-square test to describe the existence of an association between BMS and TMD. RESULTS: 65.9% the BMS patients showed disorders classified as primary signs and symptoms of TMD according to RDC / TMD criteria, and 72.7% showed parafunctional habits. The chi-square test revealed a statistically significant association (p = 0.035) between BMS and TMD. CONCLUSION: The data suggest that there is a possible relationship not yet well understood between BMS and TMD, may be for neurophatic alterations assumed for BMS that could be also engaged in TMD pathogenesis.
    International journal of medical sciences 10/2013; 10(12):1784-1789. DOI:10.7150/ijms.6327 · 1.55 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: SUMMARY Trigeminal neuropathic pains have presented diagnostic and therapeutic challenges to providers. In addition, knowledge of pathophysiology, current classification systems, taxonomy and phenotyping of these conditions are incomplete. While trigeminal neuralgia is the most identifiable and studied, other conditions are being recognized and require distinct management approaches. Furthermore, other facial pain conditions such as atypical odontalgia and burning mouth syndrome are now considered to have neuropathic elements in their etiology. This article reviews current knowledge on the pathophysiology, diagnosis and management of neuropathic pain conditions involving the trigeminal nerve, to include: trigeminal neuralgia, trigeminal neuropathic pain (with traumatically induced neuralgia and atypical odontalgia) and burning mouth syndrome. Treatment modalities are reviewed based on current and best available evidence. Trigeminal neuralgia is managed with anticonvulsant drugs as the first line, with surgical options providing variable results. Trigeminal neuropathic pain is managed medically based on the guidelines for other neuropathic pain conditions. Burning mouth syndrome is also treated with a number of neuropathic medications, both topical and systemic. In all these conditions, patients need to be thoroughly educated about their condition, involved in its management, and be provided with supportive and adjunctive treatment resources.
    07/2011; 1(4):353-65. DOI:10.2217/pmt.11.35
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Purpose This study aims to identify the prevalence of periodontal disease among menopausal women and examine factors associated with periodontal disease. Method This is an exploratory cross-sectional study, conducted by a questionnaire and an oral examination. The sample consisted of 40 women who used the services of Women's Health Foundation of Santa Casa de Misericórdia do Pará, between January and May of 2011. Results The results of this study show that 18% are brown and 45% were married. Regarding the presence of burning mouth syndrome was observed that 22.5% of women had the picture. In statistical analysis, the Spearman coefficient (rs) = 0.2436 showed a relationship between poor oral hygiene and a greater tendency to present the burning mouth syndrome (t = 1.5483 and p = 0.1298). Conclusion It is noted that the rate of periodontal disease and the high number of excluded sextants in the age group analyzed, demonstrates the care offered to these women and that the current state of health, is worsening the periodontal condition of the few remaining teeth. These results may help in the formulation of public policies aimed at promoting oral health in the region studied.
    05/2013; 28(2):61–67. DOI:10.1016/j.recli.2013.09.001

Full-text

Download
18 Downloads
Available from
Oct 16, 2014