Antimicrobial resistance of Streptococcus pneumoniae and Haemophilus influenzae isolated from children with community-acquired respiratory tract infections in Central Poland

Children's Memorial Health Institute, Warszawa, Masovian Voivodeship, Poland
International Journal of Antimicrobial Agents (Impact Factor: 4.3). 02/2004; 23(1):39-43. DOI: 10.1016/j.ijantimicag.2003.05.013
Source: PubMed


Resistance to commonly used antimicrobial agents among the key respiratory pathogens is increasing worldwide and therefore a rational choice of an empirical treatment requires knowledge of both global and local resistance patterns. The susceptibility of 185 Streptococcus pneumoniae and 169 Haemophilus influenzae isolates collected from January 1999 to May 2002 at the Children's Memorial Health Institute, Warsaw, Poland, from 351 children with community-acquired respiratory tract infections (RTIs) has been determined. Of S. pneumoniae isolates, 84% were susceptible to penicillin, 91% to cefaclor, 95% to cefuroxime, 98% to cefotaxime, 79% to erythromycin, 46% to co-trimoxazole, 82% to clindamycin and 59% to tetracycline. The majority (83%) of erythromycin-resistant isolates tested carried the erm(B) gene, conferring the MLS(B) phenotype. All tetracycline-resistant S. pneumoniae strains analysed were tet(M) positive and tet(O) negative. A total of 24% of H. influenzae isolates were beta-lactamase-positive. H. influenzae susceptibility to amoxicillin/clavulanate, cefaclor, cefuroxime, azithromycin, tetracycline and co-trimoxazole was 100, 89, 94, 96, 96 and 43%, respectively.

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    • "Lack of susceptibility to tetracyclines was the common resistance phenotype in Streptococcus pneumoniae strains isolated in Poland, with a prevalence varying from 30% up to 50%, whereas an increase in resistance to penicillin and macrolides from less than 3% to 15% has been observed within the last decade [1] [2] [3] [4]. The change in the profile of resistance was accompanied by the simultaneous emergence of the national epidemic clones Poland 23F -16 and Poland 6B - 20 and the introduction of international pandemic clones Spain 23F -1 and Spain 9V -3 to the country. "
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    Solid-State Circuits Conference, 1991. Digest of Technical Papers. 38th ISSCC., 1991 IEEE International; 03/1991
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