[Show abstract][Hide abstract] ABSTRACT: BACKGROUND: Adenomyoepithelioma (AME) of the breast is a biphasic very uncommon tumour with epithelial/ my-oepithelial components. It can be easily recognised in an excised lesion, but it is more difficult to make a definitive diagnosis with needle biopsy. CASE REPORT: We report the case of a 42-year-old woman who presented with a mass in her right breast. The patient underwent a fine needle aspiration, and a diagnosis of C5 carcinoma was made. Neoadjuvant treatment was proposed to the patient but she refused and was referred to a third level centre where a needle core biopsy was performed and a diagnosis suggestive of AME was made. CONCLUSION: If there is cytological atypia, AME may be confused with infiltrating ductal carcinoma in needle biopsies because of limited tissue sampling.
Breast Care 01/2008; 3(2):125-127. · 0.91 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Presented herein is the first case of malignant adenomyoepithelioma (malignant AME) of the breast combined with invasive lobular carcinoma (ILC) in a 53-year-old woman. Histologically, the tumor was composed of nodular proliferation of biphasic epithelial and myoepithelial carcinoma, partially surrounded by ILC. Interestingly, ILC metastasized to the axillary lymph nodes, while biphasic epithelial and myoepithelial carcinoma hematogenously metastasized to the lung and the kidney. On immunohistochemistry the biphasic carcinoma consisted of cytokeratin (CK) 8/18-positive/CK5/6-positive/smooth muscle actin (SMA)-negative inner carcinoma cells and CK8/18-positive/CK5/6-positive/SMA-positive outer carcinoma cells. The monophasic ILC cells had a CK8/18-positive/CK5/6-negative/SMA-negative staining pattern. Although it is unclear whether both ILC and biphasic epithelial and myoepithelial carcinoma originated from AME or whether ILC occurred independently of malignant AME, this is an exceptionally rare case, which might give rise to a special consideration of the histogenesis of breast cancer.
Pathology International 04/2009; 59(3):179-84. · 1.59 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Adenomyoepitheliomas are uncommon breast tumours. By definition they have a prominent component of myoepithelial cells, in addition to glandular elements lined by epithelial cells. Malignant adenomyoepithelioma of the breast is even more rare, characterised by malignant proliferation of epithelial and myoepithelial cells that show characteristic histological and immunohistochemical features. Only 11 cases have been reported to date. A case of malignant adenomyoepithelioma of the breast is reported.
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