Article

Protective effect of alpha-lipoic acid against chloroquine-induced hepatotoxicity in rats.

Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu 608 002, India.
Journal of Applied Toxicology (impact factor: 2.48). 24(1):21-6. DOI:10.1002/jat.940 pp.21-6
Source: PubMed

ABSTRACT Oral administration of a-lipoic acid, a metavitamin, was investigated for its possible hepatoprotective effect in Wistar rats against chloroquine-induced toxicity. Rats were treated orally with alpha-lipoic acid (10, 30 and 100 mg x kg(-1) day(-1)) for 7 days before a single oral administration of chloroquine (970 mg x kg(-1) day(-1)) and alpha-lipoic acid treatment was continued for three more days. The increased level of serum enzymes (aspartate transaminase, alanine transaminase and alkaline phosphatase), bilirubin, lipids and plasma thiobarbituric acid-reactive substances (TBARS) and hydroperoxides observed in rats treated with chloroquine were very much reduced in rats treated with alpha-lipoic acid plus chloroquine. A significant decrease in plasma antioxidants such as reduced glutathione (GSH), vitamin C and vitamin E were observed in chloroquine-treated rats when compared with control rats. Administration of alpha-lipoic acid significantly improved the levels of plasma antioxidants GSH, vitamin C and vitamin E in chloroquine-treated rats. In the case of 100 mg x kg(-1) day(-1) the effect was highly significant compared with the other doses (10 and 30 mg x kg(-1) day(-1)). The results of the study revealed that alpha-lipoic acid could offer protection against chloroquine-induced hepatotoxicity. alpha-Lipoic acid had a better protective effect when compared with silymarin, a reference drug.

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Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

7 days
 
alanine transaminase
 
alpha-lipoic acid
 
alpha-lipoic acid treatment
 
aspartate transaminase
 
chloroquine-induced hepatotoxicity
 
chloroquine-induced toxicity
 
chloroquine-treated rats
 
control rats
 
Oral administration
 
plasma thiobarbituric acid-reactive substances
 
possible hepatoprotective effect
 
protective effect
 
reference drug
 
serum enzymes
 
significant decrease
 
single oral administration
 
vitamin C
 
vitamin E
 
Wistar rats