Biosynthesis of the Monosaccharids

Nature (Impact Factor: 41.46). 03/1951; 167(4240):180-3.
Source: PubMed
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    ABSTRACT: A PRECISE picture of a pathway of glucose metabolism existing in addition to the classical scheme proposed by Embden, Meyerhof, Parnas, Cori and many others is slowly emerging from experiments on carbohydrate metabolism1-7. This route, proceeding by way of 6-phosphogluconate and its derivatives, is called `direct'. Some years ago, a study of aerobic and anaerobic acid formation with nitrogen-poor bacteria led one of us (J. D. L.) to suppose that, beside the classical respiration by triose phosphate dehydrogenase, our strain could equally well oxidize glucose by way of phosphogluconate, gluconate or a non-phosphorylative process8.
    Nature 10/1951; 168(4273):515-6. DOI:10.1038/168515a0 · 41.46 Impact Factor
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    Plant physiology 11/1952; 27(4):736-44. DOI:10.1104/pp.27.4.736 · 6.84 Impact Factor
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    ABSTRACT: In a previous paper (Dickens & Glock, 1951) it was shown that at least two liver factors are necessary for the oxidation of D-ribose-5-phosphate, one being a coenzyme ii-(triphosphopyridine nucleotide; TPN)-specific dehydrogenase and the other an aldolase. Two alternative mechanisms of oxidation were suggested. The first involves an aldolase split into triosephosphate and a C2 fragment, synthesis of hexosemonophosphate from two C. molecules and subsequent oxidation through the appropriate TPN-specific system. The second alternative is the direct oxidation of D-ribose-5-phosphate to 5-phospho-D-ribonic acid followed by oxidative decarboxylation as suggested by Dickens (1936, 1938) for yeast. It has now been shown that this direct oxidative pathway is unlikely to occur, at least in liver. Synthesis of hexosemonophosphate, already demonstrated by Dische (1938, 1949) with haemolysed human erythrocytes and by Schlenk & Waldvogel (1947) and Waldvogel & Schlenk (1947, 1949) with rabbit-liver preparations, has been found to occur very rapidly and to such an extent as to exclude its formation solely from triosephosphate derived from breakdown of pentosephosphate.
    Biochemical Journal 01/1953; 52(4):575-83. · 4.40 Impact Factor
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