[Show abstract][Hide abstract] ABSTRACT: Free glycerol has been identified as a major solute in plasma of pupae of the silk moth, Hyalophora cecropia. Glycerol is not found in the blood of larvae; it appears about the time of pupation, and then gradually accumulates during diapause to reach after 6 months a level of about 0.3 M. When diapause is broken and the adult develops, glycerol rapidly disappears. In diapausing pupae of the related species, Telea polyphemus, about 0.05 M glycerol was found; in 3 other saturniid species, there was little or none. It is suggested that glycerol may be a product of a modified glycolytic pathway.
The Journal of General Physiology 06/1959; 42(5):1005-11. · 4.73 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: In the context of a "glyoxylate scenario" of primordial metabolism, the reactions of dihydroxyfumarate (DHF) with reactive small molecule aldehydes (e.g., glyoxylate, formaldehyde, glycolaldehyde, and glyceraldehyde) in water were investigated and shown to form dihydroxyacetone, tetrulose, and the two pentuloses, with almost quantitative conversion. The practically clean and selective formation of ketoses in these reactions, with no detectable admixture of aldoses, stands in stark contrast to the formose reaction, where a complex mixture of linear and branched aldoses and ketoses are produced. These results suggest that the reaction of DHF with aldehydes could constitute a reasonable pathway for the formation of carbohydrates and allow for alternative potential prebiotic scenarios to the formose reaction to be considered.
Journal of the American Chemical Society 02/2012; 134(7):3577-89. · 10.68 Impact Factor
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