[Show abstract][Hide abstract] ABSTRACT: In the context of a "glyoxylate scenario" of primordial metabolism, the reactions of dihydroxyfumarate (DHF) with reactive small molecule aldehydes (e.g., glyoxylate, formaldehyde, glycolaldehyde, and glyceraldehyde) in water were investigated and shown to form dihydroxyacetone, tetrulose, and the two pentuloses, with almost quantitative conversion. The practically clean and selective formation of ketoses in these reactions, with no detectable admixture of aldoses, stands in stark contrast to the formose reaction, where a complex mixture of linear and branched aldoses and ketoses are produced. These results suggest that the reaction of DHF with aldehydes could constitute a reasonable pathway for the formation of carbohydrates and allow for alternative potential prebiotic scenarios to the formose reaction to be considered.
Journal of the American Chemical Society 02/2012; 134(7):3577-89. · 10.68 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: A PRECISE picture of a pathway of glucose metabolism existing in addition to the classical scheme proposed by Embden, Meyerhof, Parnas, Cori and many others is slowly emerging from experiments on carbohydrate metabolism1-7. This route, proceeding by way of 6-phosphogluconate and its derivatives, is called `direct'. Some years ago, a study of aerobic and anaerobic acid formation with nitrogen-poor bacteria led one of us (J. D. L.) to suppose that, beside the classical respiration by triose phosphate dehydrogenase, our strain could equally well oxidize glucose by way of phosphogluconate, gluconate or a non-phosphorylative process8.
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