Binding of the 2F5 monoclonal antibody to native and fusion-intermediate forms of human immunodeficiency virus type 1 gp41: implications for fusion-inducing conformational changes.

Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland 20892-4555, USA.
Journal of Virology (Impact Factor: 4.65). 04/2004; 78(5):2627-31. DOI: 10.1128/JVI.78.5.2627-2631.2004
Source: PubMed

ABSTRACT We investigated how the broadly neutralizing monoclonal antibody 2F5 affects the human immunodeficiency virus type 1 envelope glycoprotein as it undergoes receptor-induced conformational changes and show that 2F5 binds both native and fusion-intermediate conformations, suggesting inhibition of a late step in virus entry. We also demonstrate conformational changes in the C heptad of gp41.


Available from: Renate Kunert, Jun 12, 2015
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